EPM Medications Unlikely To Cause Drug Resistance In Disease-Causing Parasite

Horses that are diagnosed with equine protozoal myeloencephalitis (EPM) have a few options for treatment of the disease, including Marquis (ponazuril) and Protazil (diclazuril). While resistance to anthelmintics and antimicrobials are real concerns, resistance to antiprotozoals is not, Dr. Nicola Pusterla of the University of California, Davis, School of Veterinary Medicine tells The Horse.

Pusterla says that this concern is unfounded for two reasons: EPM medications would need to be overused, allowing for the hardiest organisms to survive, and this is not happening, he said. Second, Sarcocystis neurona, the primary EPM-causing organism, dies with the host, even if it becomes resistant (except if opossums scavenge the dead horse to complete the protozoa's lifecycle, which is highly unlikely).

S. neuroa requires two hosts: a definitive host, which is an opossum, and intermediate hosts, which can include raccoons, cats, skunks and armadillos. The protozoa lives in these animals for a period of time, but does not affect the animals. To complete the protozoa's life cycle, the opossum must ingest tissue from the intermediary host that contains the protozoa.

Opossums are often infected with S. neurona and are the main source of infection in horses. The horse then contracts S. neurona by ingesting food or water that has been contaminated with the opossum's feces. A horse cannot spread disease to other horses, nor can intermediate hosts spread the disease.

Because of this, a horse treated with an antiprotozoal is unlikely to harbor resistance forms of S. neurona that can be ingested by opossums, completing the life cycle of the parasite. Additionally, all FDA-approved EPM treatments have concentrations in excess of what inhibits S. neurona growth. 

Read more at The Horse. 

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Mage’s Dam Puca and GISW Dalika to Keeneland November; Both Offered by Case Clay

Puca (Big Brown–Boat's Ghost, by Silver Ghost), the dam of GI Kentucky Derby winner Mage (Good Magic), will be among the lots at the upcoming Keeneland November sale in an exclusive two-mare initial consignment offered by Case Clay's Case Clay Thoroughbred Management. The other mare in Clay's consignment will be 2022 GI Beverly D. S. winner Dalika (Ger) (Pastorius {Ger}–Drawn To Run {Ire}, by Hurricane Run {Ire}).

Puca is carrying a full-sibling to Mage, who has also placed in the GI Preakness S., GI Florida Derby and GI Haskell Invitational S. from six career starts and is scheduled to go postward in Saturday's GI Travers S. Puca's first foal is MSP Gunning (Gun Runner), while she also has a 2-year-old full-brother to Mage named Dornoch, who is entered in Monmouth Park's Sapling S. Saturday.

Dalika, who won races from 5 1/2 to 11 furlongs, is carrying her first foal to the cover of 2022 Horse of the Year Flightline (Tapit). In addition to her Beverly D. win, in which she set a new course record at Churchill Downs of 1:46.31 for the nine furlongs, Dalika won an additional three graded stakes, including the 2022 GIII Kentucky Downs Ladies Turf S., the 2022 GIII Cardinal S., and the 2021 GIII Robert G. Dick Memorial S. She won 10 races in three countries for earnings of $1.465 million and also set a course record at Kentucky Downs for one mile and 70 yards in 1:37.45.

“It's an honor to bring Puca and Dalika to the market and to be associated with such quality mares and quality pregnancies,” said Clay. “I am associated with these two particular mares already, so it's a natural extension of my business in an area in which I have been lucky enough to have experience in selling top mares. I'm looking forward to showing them to potential buyers in November.”

Both Puca and Dalika are part of Keeneland's Book 1 and are scheduled to go through Keeneland's ring Wednesday, Nov. 8.

“Keeneland is excited that Case has chosen us to offer these two exceptional broodmares in Book 1 of the November Breeding Stock Sale–and mark the debut of Case Clay Thoroughbred Management,” said Keeneland Vice President of Sales Tony Lacy. “While at Three Chimneys Farm, when it was owned by his family, Case oversaw the sale of a large number of million-dollar-plus broodmares over many years, including the great Take Charge Lady here at Keeneland in 2004. Along with this experience at the top end, he has an extraordinary number of connections and relationships with domestic and international buyers.”

“It's really just a vertical integration to my business for my clients, in an area in which I am lucky enough to have a lot of experience, as Three Chimneys used to consign a lot of mares when I was there full-time,” Clay said. “It is similar to my equine insurance business, which began during Covid, when one of my clients asked how he should insure his filly. There wasn't a lot going on at the time, so I got my license.”

Harkening back to his days at Three Chimneys, Clay amassed quite a record selling million-dollar-plus mares to the top players in the business. He said he has no plans to expand into the yearling consignment business.

“The November Sales were my favorite, since they follow the Breeders' Cup and everyone is in good spirits,” Clay said. “Selling high-quality fillies and mares is always a charge.”

The November Breeding Stock Sale catalogue will be released online Tuesday, Oct. 3.

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Stars Come Out To Play on Travers Day

It's a bit of Christmas in August Saturday at venerable Saratoga Race Course, which plays host to no fewer than five Grade I events for horses of all ages–on dirt and on turf–topped by the main event on the summer calendar, the $1.25-million GI Travers S. While the fields are short on numbers, they are long on quality, as three of the races have attracted reigning Eclipse Award winners, none of whom are anything close to a cinch in their respective heats.

Champion and 'TDN Rising Star' Forte (Violence) has had a tumultuous first two-thirds of the season but has his chance to put it all behind him on Saturday. Having defeated future GI Kentucky Derby hero Mage (Good Magic) in the GI Curlin Florida Derby Apr. 1, the $110,000 Keeneland September bargain was famously withdrawn on the eve of the Run for the Roses–for which he was likely to start favorite–and was first off a 71-day absence in the GI Belmont S. June 10. A highly creditable second to the race-fit Arcangelo (Arrogate), the dark bay exits a rough-and-tumble nose victory after surviving a lengthy inquiry in the GII Jim Dandy S. July 29. But here he is, a golden opportunity to cement his spot at the head of this year's sophomore class straight ahead.

“You're never going to make up for not getting to run in the Kentucky Derby,” Todd Pletcher told TDN's Mike Kane at Tuesday's draw. “But it would be, I suppose, some sort of consolation prize if we were able to win the Travers against the three Classic winners.”

Pletcher has been twice successful in the Travers, most recently with Belmont runner-up Stay Thirsty (Bernardini) in 2011.

The third of the Classic winners to whom Pletcher refers is National Treasure (Quality Road), who outlasted Blazing Sevens (Good Magic) and Mage to win the GI Preakness S. The $500,000 Fasig-Tipton Saratoga grad set a moderate pace when last seen in the Belmont, but gave way readily in the stretch to finish sixth. He looms part of the early pace equation with the outposted Curlin S. hero Scotland (Good Magic) and leaves from gate five with John Velazquez calling the shots. Blinkers come off for the Travers.

“I just got a text from Bob [Baffert] and he loves the post. I don't disagree with Bob too many times,” said Starlight Racing's Jack Wolf. “If he wants to take the blinkers off or put triple blinkers on, that's fine with me.”

Mage, who looks to become the first Derby winner to double up in the Travers since Street Sense in 2007, passed the Belmont and reportedly was underdone when nearly overcoming a wide trip to drop a narrow decision to Geaux Rocket Ride (Candy Ride {Arg}) in the GI TVG.com Haskell S. five weeks ago. Flavien Prat has been named to replace the injured Luis Saez.

Baffert was deep into his Hall of Fame career when sending out Arrogate to that stunning victory in the 2016 Travers, and the late stallion has a chance to join the fellow Travers winners Easy Goer, Birdstone and Bernardini as sires to account for a Travers winner of their own. Arcangelo's rise has been meteoric, as he progressed from a third-out graduation to victory in the GIII Peter Pan S. and an historic Belmont S. score for trainer Jena Antonucci. He makes his first start in 77 days Saturday, but that is of little concern to his connections.

“He's grown up so much and has gotten stronger and more professional over this little bit of a breather we gave him,” Antonucci said. “We're so thrilled to be here and blessed to do this. To have the opportunity to be here at this stage is amazing.”

Winchell Thoroughbreds looks to become the first owner since Ogden Phipps in 1989 and 1990 to score consecutive Travers wins. Disarm (Gun Runner), whose boom sire was a distant third to Arrogate seven years ago, was a troubled fourth in the Derby and won the GIII Matt Winn S. at Ellis June 11, but was a bit one-paced when fourth in the Jim Dandy. To that end, trainer Steve Asmussen tweaks the colt's equipment this weekend.

“We need to find more,” he said of the decision to add blinkers. “We aren't satisfied with the results of his last race and I think he's capable of more. This is our first step in trying to pull it out of him.”

'TDN Rising Star' and GI Toyota Blue Grass S. hero Tapit Trice (Tapit) tries to give his all-conquering stallion a second Travers winner in three years. Seventh in the Derby and third in the Belmont, he'll need to improve many lengths off his latest fifth in the Haskell.

Plenty Of Talent On the Travers Undercard

The elite-level action kicks off with the GI Forego S., a five-horse affair that shapes more like a match race. Juddmonte's Eclipse-champion sprinter Elite Power (Curlin) has very much lived up to his name and carries an eight-race winning streak into the seven-furlong test. To make it nine on the trot, he'll have to once again run down Gunite (Gun Runner), who appeared every ounce a winner in a sloppy renewal of the GI A. G. Vanderbilt H. July 29, only to be run down in the last couple of jumps. The latter was in receipt of just two pounds last month in the handicap, but is critically four pounds better off this time around (124-118).

Elite Power and Gunite threw down in the Vanderbilt | Sarah Andrew

Whereas the two older sprinters should boss the Forego, the GI H. Allen Jerkens S. looms a much more competitive affair, where a case could be made for at least five of the six entrants.

David Aragona has tabbed 'TDN Rising Star' Arabian Lion (Justify) as the 2-1 favorite on the morning line off his victory in the GI Woody Stephens S. downstate June 10, but so open is the Jerkens that Drew's Gold (Violence,) who endured his first career defeat that day, is the 12-1 outsider. New York Thunder (Nyquist) turned in a Shancelot-esque effort in winning the GII Amsterdam S. by 7 1/2 lengths July 28 to remain unbeaten in four starts, while Fort Bragg (Tapit) drops back in trip off a nose success over subsequent Jim Dandy runner-up Saudi Crown (Always Dreaming) in the GIII Dwyer S. July 1. Even Verifying (Justify) cannot be ruled out, as tries a sprint trip for the first time since debuting victoriously here over six furlongs 366 days ago. The half-brother to Midnight Bisou (Midnight Lute) gutted it out in the GIII Indiana Derby July 8.

A pair of former champions lock horns in the GI Ballerina S., a 'Win and You're In' qualifier for the GI Breeders' Cup Filly & Mare Sprint in early November.

Goodnight Olive (Ghostapper) was making her graded stakes debut in last year's Ballerina and went on to best Caramel Swirl (Street Sense) by 2 3/4-lengths en route to a victory by a similar margin over champion 'Rising Star' Echo Zulu (Gun Runner) in the Filly & Mare Sprint. Easy winner of the GI Madison S. on seasonal debut in April, the dark bay was an unlucky third behind Matareya (Pioneerof the Nile) in the GI Derby City Distaff May 6 and just managed to stave off Wicked Halo (Gun Runner) in the GII Bed O'Roses S. June 17. The latter would go on to frank the form in the July 23 Twin Bridges S. at Ellis.

Echo Zulu is perfect in her two runs this season at four, a 5 3/4-length tally in the May 29 GIII Winning Colors S. followed by a 7 1/4-thumping of Dr B (Liam's Map) in the GII Honorable Miss H. here July 26.

The GI Resorts World Casino Sword Dancer S. offers a fees-paid berth into the GI Breeders' Cup Turf and, really, what's not to admire about the evergreen Channel Maker (English Channel)? A winner of nearly $3.9 million in a career spanning 54 starts to date, horse racing's version of Cal Ripken, Jr. makes a mind-boggling sixth consecutive appearance in the Sword Dancer, including a front-running 5 3/4-length score in a soft-turf renewal in 2020. The chestnut doesn't appear to be slowing down either, as he exits a two-length defeat of Verstappen (War Front) in the GII Bowling Green S. July 30, a race marred when favored Rebel's Romance (Ire) (Dubawi {Ire}) clipped heels and fell.

Peter Brant, Mrs. John Magnier, Derrick Smith and Westerberg's Stone Age (GB) (Galileo {Ire}) was a one-paced third in last year's GI Saratoga Derby and now calls New York home for trainer Chad Brown. Runner-up to Rebel's Romance in last year's GI Breeders' Cup Turf, the dark bay was beaten a long way from home when last seen in the Listed HH The Amir Trophy in Qatar this past February.

Soldier Rising (GB) (Frankel {GB}) was beaten a length into third by then-stablemate Gufo (Declaration of War) in this event last year and was runner-up in the GI Man O'War S. and GI Manhattan S. this spring. He arguably took the worst of it in the Bowling Green and can rebound at a hint of a price here.

Breeders' Cup Berth Up For Grabs In Pat O'Brien

The seven-furlong GII Pat O'Brien S. offers its winner a spot in the field for the GI BigAss Fans Breeders' Cup Dirt Mile up the road at Santa Anita and has drawn a field of 11 that lacks a true standout.

Though still eligible for a second-level allowance, Anarchist (Distorted Humor) was runner-up in the GIII San Simeon S. down the hill in Arcadia Mar. 5 and filled the same spot in the GIII Kona Gold S. on the dirt Apr. 22 before shipping into Woodbine to salute in the May 14 GIII Jacques Cartier S. Second to Elite Power in the GII True North S. June 10, he missed by a head to the outstanding Cal-bred The Chosen Vron (Vronsky) in the GI Bing Crosby S. July 29.

Brickyard Ride (Clubhouse Ride) was a short-priced third in the San Simeon before validating 4-5 favoritism in the Kona Gold with a half-length defeat of Anarchist. The 6-year-old entire was a well-beaten third to The Chosen Vron in the state-bred Thor's Echo S. May 28 and cuts back to a sprint after rounding out the trifecta when trying to wire the field in the GII San Diego H. July 29.

A miniature version of Channel Maker, C Z Rocket (City Zip) tries the O'Brien for a fourth straight time at age nine. Victorious in 2020 when also second in the GI Breeders' Cup Sprint, he rounded out the exacta again in 2021, but was a slow-starting eighth last year. The bay ran on some to be fifth in the Crosby and gets blinkers back on Saturday.

The Estate of the late Jerry Moss is represented by the lightly raced homebred Sir Atticus (Gormley), winner of a 6 1/2-furlong allowance July 21 for which he earned a competitive 94 Beyer Speed Figure.

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The Friday Show Presented By Woodbine: Answering Reader Questions With Gary Contessa

We're switching things up a bit on this week's episode of The Friday Show.

If you follow us on Instagram or subscribe to the Paulick Report Insider Patreon feed, you're familiar with our “Ask Me Anything” video series, where a member of our staff answers reader questions about horse racing, or whatever else passes through the inbox.

During a recent trip to Saratoga, we decided to get some members of the racing industry in on the action, including trainer Gary Contessa, who is never afraid to share his opinion.

Contessa has had a long career as a New York-based trainer and has campaigned Uncle Sigh, Rydilluc, Eightyfiveinafifty, Rite Moment and Sippican Harbor. He has spent time both as a private trainer and managing a public barn, is a breeder, and scouts yearlings and 2-year-olds at the sale. He's also president of The Exceller Fund, which facilitates aftercare for Thoroughbreds at risk of neglect or entry into the slaughter pipeline.

Contessa was so thorough with his answers to our readers' questions that we split it into a two-part video on our Patreon.

On this week's episode of The Friday Show, we'll share one of those parts, where Contessa discusses topics including how much it costs to keep a horse in training, how a new owner can find a “clean” trainer, and what the industry can do to lower the number of equine fatalities.

If you enjoyed this “Ask Me Anything” video and want to see more like it from Paulick Report staff and Thoroughbred industry members, become a subscriber to the Paulick Report Insider Patreon account by clicking here.

Watch this week's episode of The Friday Show below:

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