Connemara ponies can suffer from a genetic mutation causing hoof wall separation disease (HWSD), in which the hoof wall splits along its weight bearing surface. Often confused with white line disease or laminitis, HWSD differs from these conditions as the separation occurs within the hoof wall, rather than between the hoof wall and the coffin bone.
Researchers at the Bannasch Laboratory, part of the UC–Davis School of Veterinary Medicine, recently discovered the genetic mutation responsible for HWSD.
They suspected that the condition was autosomal recessive as HWSD-affected ponies typically have two normal parents, but begin showing signs of the condition by the time they are a year old. In autosomal recessive conditions, individuals that carry two copies of the mutated gene are affected.
“Carriers” are unaffected and carry only one copy of the faulty gene, but if two carriers are bred and both pass on a copy of the mutated gene, the foal develops HWSD.
The researchers used genome-wide association analysis to identify the chromosome in which the defective gene was located. The mutation was found in a gene that produces a protein called SERPINB11, but it is unclear whether SERPINB11 plays a role in the production and maintenance of normal hoof wall tissue.
In a study group of more than 300 Connemara ponies, 22 had double copies of the faulty gene and showed signs of HWSD. None of the control horses carried two copies and all had normal hooves.
The scientists also determined that nearly one in seven unaffected ponies carried one copy of the mutated gene.
Read more at EQUUS magazine.
The post Genetic Mutation Causes Hoof Wall Separation Disease In Connemara Ponies appeared first on Horse Racing News | Paulick Report.
The powerful team of owner/breeder Godolphin, trainer Charlie Appleby and jockey William Buick celebrated a second lucrative victory over the Saratoga turf in as many days as With The Moonlight led home a one-two finish for her sire in the GIII Saratoga Oaks Invitational Sunday. Having finished second to re-opposing McKulick (GB) (Frankel {GB}) in the July 9 GI Belmont Oaks Invitational, she was backed at even-money with a perceived pace advantage on that rival and after stablemate Nations Pride (Ire) (Teofilo {Ire}) parlayed a second in last month's GI Caesars Belmont Derby Invitational to a victory in Saturday's GI Caesars Saratoga Derby Invitational.
Visibly lathered, the bay and Buick allowed McKulick's stablemate Contemporary Art (Dubawi {Ire}) to show the way as they sat second by a couple of lengths. She sidled up to the pacesetter aggressively after six panels in 1:15.18 with McKulick swinging wide to join the fray. But neither Brown filly could run with the European raider in the stretch as she pulled away powerfully on her incorrect lead.
“She felt really good today,” Buick said. “I think the team had been really happy with the way she was training, so they were quietly confident going into it.
“She travels very well, which is key really. Our horses coming from Europe to here, they always improve with one run on these tracks. It's a lot different for them. Yesterday [with Nations Pride] and the filly today, they were always going to improve off that first run and I think they showed that.
“It's nice to come over here with two nice horses, two nice rides and two winners. It's a real privilege to be here to be honest. It really feels special.”
Scoring twice on all weather from four tries overall in England as a juvenile, With The Moonlight resurfaced to annex Newmarket's May 1 Pretty Poly S. convincingly over 10 panels, but faded abruptly to last in the G1 Cazoo Oaks the following month. She was ridden by Frankie Dettori in the Belmont Oaks.
“They went hard at Belmont and to be fair to Frankie, it was the first time he'd sat on her and I said, 'look, ride her like she'll get the trip,'” said Appleby, whose banner 2021 included eight Grade I wins in North America, including three on Breeders' Cup weekend. “On the evidence of today and evidence of that day, coming back a half a furlong suited her. She's got plenty of boot. You could almost bring her back to a mile. The more races she's got, the more experience she's got. She's learning how to do it. It was a good performance today.”
Appleby said With The Moonlight would not return for the 1 1/2-mile GIII Jockey Club Oaks Invitational downstate Sept. 17.
“The question mark was whether the Oaks would be something to look at, but that's clearly not an option for her,” Appleby said. “William said that was far enough for her today.”
Appleby isn't done for the Saratoga meet, however. He's pointing last year's champion turf male, GI Breeders' Cup Turf and Jockey Club Derby Invitational winner Yibir (GB) (Dubawi {Ire}) to the GI Resorts World Casino Sword Dancer S. Aug. 27.
“That's the plan,” he said.” He ships out on the 17th or 18th. He's in great order. It's been a long-term plan. We had a couple bumps in the road early on at Belmont [when third in GI Man o' War in May]. Unfortunately, the rain came in and there was no pace in the race. But, with what we've seen at home, we're very pleased with the way he's done so far. If he ships in well, he'll be a big player.”
Sunday, Saratoga
SARATOGA OAKS INVITATIONAL S.-GIII, $651,000, Saratoga, 8-7, 3yo, f, 1 3/16mT, 1:54.60, fm.
1–WITH THE MOONLIGHT (IRE), 121, f, 3, by Frankel (GB)
1st Dam: Sand Vixen (GB) (GSW-Eng, $119,931), by Dubawi (Ire)
2nd Dam: Fur Will Fly (GB), by Petong (GB)
3rd Dam: Bumpkin (GB), by Free State (Ire)
1ST GRADED STAKES WIN. O/B-Godolphin (IRE); T-Charles
Appleby; J-William T. Buick. $375,000. Lifetime Record:
GISP, 8-4-1-1, $559,271. *Full to Dream Castle (GB), G1SW-UAE,
GSP-Tur, MGSP-Eng, $863,725. Werk Nick Rating: A+++.
*Triple Plus* Click for the eNicks report & 5-cross pedigree.
2–McKulick (GB), 121, f, 3, Frankel (GB)–Astrelle (Ire), by
Makfi (GB). (180,000gns Ylg '20 TATOCT). O-Klaravich Stables,
Inc; B-Essafinaat UK Ltd (GB); T-Chad C. Brown. $130,000.
3–New Year's Eve, 121, f, 3, Kitten's Joy–Awesome Rafaela
(Brz), by Elusive Quality. ($110,000 RNA Ylg '20 KEESEP;
$105,000 Ylg '20 FTKOCT). O-Marc Detampel & Fergus Galvin;
B-Stud TNT LLC (KY); T-Brendan P. Walsh. $70,000.
'TDN Rising Star'.
Margins: 1 3/4, NK, 3/4. Odds: 1.15, 1.40, 10.80.
Also Ran: Contemporary Art, Oakhurst. Scratched: Walkathon.
Click for the Equibase.com chart, the TJCIS.com PPs or the free Equineline.com catalogue-style pedigree. VIDEO, sponsored by TVG.
Pedigree Notes:
With The Moonlight is the 63rd graded/group winner for her talented sire, and is bred on the same cross as this year's G1 Tattersalls Irish One Thousand Guineas heroine Homeless Songs (Ire) and last year's G1 Epsom Derby winner Adayar (Ire). Dubawi, meanwhile, is the broodmare sire of 27 grade/group winners worldwide.
Dam Sand Vixen, meanwhile, cost approximately $205,000 as a Tattersalls breeze-up buy and was a Group 2 winner as a juvenile. With The Moonlight's older full-brother Dream Castle (GB) took the 2019 G1 Jebel Hatta in Godolphin blue.
Sand Vixen has an unraced 2-year-old filly by Cracksman (GB), yearling filly by Blue Point (Ire) and a foal colt by Earthlight (Ire).
The post Team Godolphin Goes One Better Again in Saratoga Oaks appeared first on TDN | Thoroughbred Daily News | Horse Racing News, Results and Video | Thoroughbred Breeding and Auctions.
e Five Racing Thoroughbreds' Pink Hue (f, 2, Mendelssohn–Involved, by Speightstown) was a bit short of running room when push was about to come to shove in Sunday's sixth race going two turns over the Saratoga turf course, but once the daylight came, the $310,000 Keeneland September graduate went through her gears and ran up the score to defeat the well-meant Xigera (Nyquist) by 2 3/4 resounding lengths.
Guided down onto the fence after brushing with a rival at the break, Pink Hue got a foothold at the fence from fourth as La Grotte (Bolt d'Oro) led from Xigera, who looked a bit reluctant to settle for Julien Leparoux. The latter–off at 6-1 from a 15-1 morning line–was given a very confident steer and tried to pinch the race in upper stretch, but Pink Hue, locked away inside but traveling strongly passing the quarter pole, found a gap three off the fence with a bit more than an eighth of a mile to gallop and she was off and gone from there. Pink Hue was the workmate of race five winner Raging Sea in the lead-up to this debut.
Pink Hue is the seventh individual winner for her freshman sire (by Scat Daddy) and the Keeneland September topper's first to be named a 'Rising Star'. She is a half-sister to Godolphin's Man of Promise (Into Mischief, $560,378), impressive winner of the G3 Nad al Sheba Turf Sprint at Meydan this past March and subsequently third in the G1 Al Quoz Sprint. Involved, a two-time winner at the races, is a half-sister to dual Grade III winner Skip to the Stone (Skip Trial) and to the stakes-winning My Heavenly Sign (Forest Camp), dam of SP Avasarala (Point of Entry). Not covered during the 2020 breeding season, Involved sold for just $8,000 at the 2021 Keeneland January Sale and most recently produced a colt by Audible.
6th-Saratoga, $105,000, Msw, 8-7, 2yo, f, 1 1/16mT, 1:42.51, fm, 2 3/4 lengths.
PINK HUE, f, 2, by Mendelssohn
1st Dam: Involved, by Speightstown
2nd Dam: Winner's Ticket, by Jolie's Halo
3rd Dam: Ticket to Paradise, by Alydar
$310,000 Ylg '21 KEESEP. Lifetime Record: 1-1-0-0, $57,750. Click for the Equibase.com chart or VIDEO, sponsored by TVG. Click for the free Equineline.com catalog-style pedigree.
O-e Five Racing Thoroughbreds; B-Betz/Davidson/C.Kidder/CoCo Equine (KY); T-Chad C. Brown.
The post Pretty In Pink: A Mendelssohn Rising Star at Saratoga appeared first on TDN | Thoroughbred Daily News | Horse Racing News, Results and Video | Thoroughbred Breeding and Auctions.
