Should Exercising Horses Receive Supplemental Antioxidants?

Among many other benefits, regular exercise enhances antioxidant defenses in horses. During exercise, aerobic cells generate reactive oxygen species (ROS), which are unstable atoms or molecules produced during normal cell metabolism. An overabundance of ROS can crush antioxidant defenses, leading to detrimental effects on muscle function. In an effort to quell the damage caused by ROS, researchers set out to determine the effect of N-acetyl cysteine and coenzyme Q10 supplementation on ROS in skeletal muscle of exercising horses.

Seven Thoroughbreds were used in the study, all engaged in the same training program: galloped 1.5 miles on the track three days a week, and walked and trotted on an automated exerciser three days a week. Horses were allowed access to pasture four days each week, three hours on exercise days and eight hours on their rest day. Horses were fed timothy hay ad libitum and a performance concentrate based on weight three times a day. Horses were supplemented daily with 10 g of N-acetyl cysteine and 1.6 g of coenzyme Q10.

Thirty days after supplementation began, horses performed an exercise test that consisted of a half-mile breeze on a racetrack at top speed. A second exercise test was performed at 60 days, with the same experienced rider instructed to replicate the speed from the earlier exercise test.

Muscle samples were taken the day before both exercise tests and one hour after each exercise test. Concentrations of antioxidants, cysteine, and ROS were measured. Blood samples were pulled prior to the exercise test and 10 minutes, one hour, and four hours after the exercise test.

The researchers concluded that supplementation of exercising Thoroughbred horses with N-acetyl cysteine and coenzyme Q10 for 30 days influenced antioxidant status without detrimental effects on performance.

Athletic performance and muscle diseases such as myofibrillar myopathy, equine motor neuron disease, and vitamin E responsive myopathy are affected by antioxidant status. Kentucky Equine Research has formulated multiple antioxidants designed for equine athletes, notably MFM Pellet, a palatable source of N-acetyl cysteine; Nano-E, a natural-source, water-soluble vitamin E supplement, and Nano-Q10, a highly bioavailable form of coenzyme Q10.

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“We have already seen the impact of this research, and horses diagnosed with myofibrillar myopathy are now being supplemented with MFM Pellet,” explained Marisa Henry, the lead author on the research paper. “We have heard glowing reviews from the owners of horses who have seen much improvement with MFM Pellet!”

This new study represents another chapter in the longstanding association between Kentucky Equine Research, Stephanie Valberg, D.V.M., Ph.D., and her colleagues, including Henry. Valberg is the director of the Equine Neuromuscular Diagnostic Laboratory and Mary Anne McPhail Dressage Chair in Equine Sports Medicine at Michigan State University, Department of Large Animal Clinical Sciences.

*Henry, M.L., D. Velez-Irizarry, J.D. Pagan, L. Sordillo, J. Gandy, and S.J. Valberg. 2021. The impact of N-acetyl cysteine and coenzyme Q10 supplementation on skeletal muscle antioxidants and proteome in fit Thoroughbred horses. Antioxidants 10:1739.

Article reprinted courtesy of Kentucky Equine Research (KER). Visit equinews.com for the latest in equine nutrition and management, and subscribe to The Weekly Feed to receive these articles directly (equinews.com/newsletters).   

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Do Fatty Acids Benefit Foals In Utero?

Omega-3 fatty acids have many favorable health effects on horses, including joint, respiratory, and reproductive benefits. Supplementing pregnant mares with omega-3s late in gestation has advantages for their developing foals. However, not all types of omega-3 supplements fed to mares have the same effectiveness.

The two major sources of omega-3 fatty acids for horses are:

Plant-derived short-chain omega-3 fatty acids, primarily alpha linoleic acid (ALA). High levels of ALA are found in flaxseed, canola oil, and other feedstuffs, but ALA must be converted by the horse to long-chain omega-3 fatty acids, including DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid) for optimal use by horses.

Marine-derived omega-3s rich in the specific omega-3 fatty acids DHA and EPA. Providing a direct source of these omega-3 fatty acids may be preferred, as the conversion of ALA to long-chain fatty acids is limited in horses.

No study has determined if the omega-3s offered in a mare's diet actually reaches her unborn foal.

To fill this knowledge gap, researchers recently designed a study to measure omega-3 fatty acid levels in foals from supplemented mares. Three diets that provided a similar total amount of omega-3 fatty acids from two different sources were used. The first was a control diet, the second was the control diet plus a commercial flaxseed supplement, and the third was the control diet with a commercial marine-derived omega-3 supplement.

When mares were offered each of these supplements during the last 30 days of gestation, only marine-derived supplementation resulted in a significant increase in DHA levels in foals.

The DHA measured in blood samples from foals born to mares offered only the control diet was 0.6 g/100 g of lipid (fat). In the foals from mares supplemented with the marine-derived omega-3, the DHA was significantly higher at 1.9 g/100 g lipid.

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“No difference in foal DHA blood levels was observed between the control and flaxseed diets, which means these results support the recommendation to provide a direct source of DHA and EPA due to the low conversion rate of ALA to DHA,” relayed Catherine Whitehouse, M.S., a nutritionist for Kentucky Equine Research.

Even though mares were supplemented during the first five days after foaling and foals were nursing those mares, DHA levels declined rapidly. By day five, DHA levels were similar across all diets. On day 30, which was 25 days after the mares were no longer supplemented, the DHA blood level of the foals was only 0.1 g/100 g lipid.

“Continuing to supplement mares throughout nursing until weaning may help maintain higher DHA levels in foals after foaling, providing long-term advantages to growth and development,” suggested Whitehouse.

EO-3, a marine-derived omega-3 supplement developed by Kentucky Equine Research, provides research-proven levels of DHA and EPA, can be top-dressed onto feed easily.

*Snyder, J. N. Shost, R. Miller, K. Fikes, R. Smith, B. Corl, A. Wagner, I. Girard, and J. Suagee-Bedore 2021. Late gestation supplementation of long-chain fatty acids increases foal docosahexaenoic acid concentrations at birth. Journal of Equine Veterinary Science 100:103522.

Article reprinted courtesy of Kentucky Equine Research (KER). Visit equinews.com for the latest in equine nutrition and management, and subscribe to The Weekly Feed to receive these articles directly (equinews.com/newsletters).   

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Rohaan to Be Supplemented to July Cup

Dual group winner Rohaan (Ire) (Mayson {GB}), who won the Wokingham S. at Royal Ascot when last seen on June 19, will be supplemented on Monday for the G1 Darley July Cup at Newmarket on July 10. The gelding took the G3 Pavilion S. in April, before being purchased privately by Chris Kiely Racing Ltd. and James Tomkins. He then saluted in the G2 Sandy Lane S. at Haydock on May 22. In the latter, the David Evans trainee defeated Dragon Symbol (GB) (Cable Bay {Ire}), who was first past the post in the G1 Commonwealth Cup S., but demoted to second by the stewards for interference.

“We didn't expect him to perform as he has in his last two runs and we didn't want to take on the older horses, but now with the figures he produced at Ascot, we haven't a choice now,” said Kiely, who is also a professional gambler. “We have to go and take them on. We're looking like we might get the ground we need. We probably wouldn't run him if there was firm in the ground description.

“The horse is in the form of his life, he takes his racing incredibly well. It's a race we'll never get another stab at and it's the chance of a Group 1.

“The horse is on an upward curve and I think we go there with an incredible chance and if there was rain to come we'd go and be almost favourite. It's an incredibly hot race and it's nice to be part of it.

“If all goes well in the July Cup, we might go for the [G1] Maurice de Gheest four weeks later. He takes his races so well. While the iron is hot you have to strike, so we're going to supplement him and pray for rain.”

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Daughter of Sea the Stars Added to Arqana October

A yearling filly by Sea The Stars (Ire) is a late addition to the Arqana October Yearling Sale Part I on Oct. 19-23. Offered by Haras d’Etreham as lot 110bis, she is out of Scandinavian champion Matauri Pearl (Ire) (Hurricane Run {Ire}), herself a full-sister to MGSW & MG1SP Wekeela (Fr) (Hurricane Run {Ire}). In the extended family is MG1SW and star sire Monsun (Ger) (Konigsstuhl {Ger}), as well as dual Classic hero Brametot (Ire) (Rajsaman {Fr}). The five-day sale will see 785 yearlings go under the hammer at Deauville.

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