The Need For Speed: Genetic Editing Can Create Faster Horses

Argentinian researchers have created horse embryos after editing a specific speed gene with CRISPR/Cas9 technology. Drs. Lucia Natalia Moro, Diego Luis Viale, Juan Ignacio Bastón, Victoria Arnold, Mariana Suvá, Elisabet Wiedenmann, Martín Olguín, Santiago Miriuka and Gabriel Vichera are hopeful that the new technology will create horses with improved athletic ability; it could also be used to correct genetic defects that cause equine disease.

The scientists were successful in removing the myostatin gene, which inhibits skeletal muscle mass development. This gene plays a significant role in gene-based distance aptitude of racehorses. Their gene editing techniques achieved 96.2 percent efficacy.

The team noted that additional research to determine an efficient manner of editing embryos was needed before this technique could be used to improve the athletic performance of horses. The team's long-term goal is to identify alleles that give a horse a natural sporting advantage and then incorporate them to allow other horses the same characteristics. They consider this technique a precision breeding strategy as it can deliver results to only one generation.

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Does Suture Material Affect Surgery Speed?

Gelding operations are among the most-performed surgical procedures in the equine veterinary world. Though this surgery has been performed for many years, there is always room for potential improvement.

Drs. Ditte Marie Top Adler, Stine Østergaard, Elin Jørgensen and Stine Jacobsen, of the University of Copenhagen, wanted to compare a new, barbed suture martial to traditional suture material that requires the surgeon to make multiple knots to keep the stitches in place. The barbed suture material has tiny barbs on the surface that lock the material in place, eliminating the need for knots. Manufacturers claim the barbs make the material more secure and increase the speed at which the castration can be performed.

The research team used 45 horses that were brought to The Large Animal Teaching Hospital at the University of Copenhagen for inguinal castrations; 24 of the horses were sutured with smooth material and 21 were sutured with the barbed material. The scientists then evaluated any complications while the horse was in and out of the hospital. They also compared how long it took the veterinarian to close the surgical wounds.

There were minor short-term complications; swelling was noted in 29 percent of the stallions that had the barbed suture material and in 33 percent of the horses that had the smooth suture material. Three horses required follow-up care for castration complications. One had scrotal swelling (barbed suture material had been used); one had a weeping wound (smooth suture material had been used); and one had the wound reopen (smooth suture material had been used).

Veterinarians using the barbed suture material were able to close the wound six minutes faster than using smooth suture material.

Though the cost of barbed suture material is higher, it reduced surgery time by 40 percent and it did not result in increased post-op complications.

Read the full article here.

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