TDN Kentucky Oaks Top 10 for Apr. 1

The big story last week was the return of Eclipse Award winner Echo Zulu (Gun Runner) in the GII Twinspires.com Fair Grounds Oaks, which she won by a nose over Hidden Connection (Connect) to stay unbeaten in five career starts. There will be plenty going on Saturday, with Secret Oath (Arrogate) stepping outside of her division to take on males in the GI Arkansas Derby and Kathleen O. (Upstart) looking to stay hot in the GII Gulfstream Park Oaks. A GI Kentucky Oaks contender could also come out of the $250,000 Bourbonette Oaks at Turfway.

1) SECRET OATH (Arrogate–Absinthe Minded, by Quiet American) O-Briland Farm; B-Briland Farm, Robert & Stacy Mitchell (KY); T-D. Wayne Lukas. Lifetime Record: GSW, 5-3-0-1, $285,167. Last Start: 1st GIII Honeybee S. Next Start: GI Arkansas Derby, OP, Apr. 2. KY Oaks Points: 60.

This could be the last week that Secret Oath is included in our Oaks rankings as there's a strong chance that after Saturday she will be off the Oaks trail and instead on her way to the GI Kentucky Derby. How she performs in the Arkansas Derby will likely decide just that. Should she beat the boys Saturday, it's hard to imagine that trainer Wayne Lukas and owners Rob and Stacy Mitchell won't take what would be the next logical step and go in the Derby.

The Secret Oath team has found the perfect spot to test their star filly against males. She's the 5-2 morning line favorite in a $1.25-million race and will likely go off lower than that versus what is not a particularly strong group of male rivals. She is the only horse in the race to run a Beyer number in the 90s, something she has done twice. They have nothing to lose by trying this. Should she win, she would likely be on track for the Derby. If she falls short, they can go back to Plan A and run in the Oaks. A fascinating story. Will be fun to see how this plays out Saturday.

2) ECHO ZULU (Gun Runner–Letgomyecho, by Menifee) 'TDN Rising Star' O-L and N Racing LLC & Winchell Thoroughbreds LLC; B-Betz/J. Betz/Burns/CHNNHK/Magers/CoCo Equine/ Ramsby (KY); T-Steve Asmussen. Sales History: $300,000 ylg '20 KEESEP. Lifetime Record: Ch. 2yo Filly, MGISW, 5-5-0-0, $1,720,000. Last Start: 1st GII Twinspires.com Fair Grounds Oaks. Next Start: GI Longines Kentucky Oaks, May 6, Churchill Downs. KY Oaks Points: 130.

What should we make of her narrow win Saturday in the Fair Grounds Oaks? It's not an easy question to answer. On the one hand, it was her first start after a lengthy layoff and trainer Steve Asmussen had been saying all along that he hadn't really cranked his filly up just yet. She also showed some grit and determination to prevail over a quality rival in Hidden Connection. All signs point to her running better in the Oaks. Then again…weren't you expecting more?

She is a champion and a GI Breeders' Cup Juvenile Fillies winner and some thought she might be better than the best of the boys. It wasn't unreasonable to expect that she would thrash her rivals, win by six or seven while crossing the wire with her ears pricked. It's also worth noting that she got an 88 Beyer, making this the slowest race of her career. Is the 5-2 favorite in the Oaks Future Wager. Not all great 2-year-olds turn into great 3-year-olds. The jury is out.

3) ADARE MANOR (Uncle Mo–Brooklynsway, by Giant's Causeway) O-Michael Lund Petersen; B-Town & Country Horse Farms, LLC & Gary Broad (KY); T-Tim Yakteen. Sales History: $180,000 ylg '20 FTKFEB; $190,000 RNA ylg '20 FTKSEL; $375,000 2yo '21 OBSOPN. Lifetime Record: GSW, 4-2-1-0, $56,600. Last Start: 1st GIII Las Virgenes S. Next Start: GII Santa Anita Oaks, SA, Apr. 9. KY Oaks Points: 0.

Unraced since romping by 13 lengths in the GIII Las Virgenes S. on Feb. 6 at Santa Anita, she has been transferred to the barn of former Bob Baffert assistant Tim Yakteen. Owner Michael Lund Petersen was forced to make the move because it looks like Baffert will not be eligible to start any horses in the Oaks due to his problems stemming from the betamethasone positive from last year's Derby.

Because Baffert-trained horses were not eligible to earn Kentucky Oaks points, Adare Manor doesn't have any yet. But that shouldn't be a problem. She will be the heavy favorite next week in the GII Santa Anita Oaks and a win or even a second-place finish there should get her to the Kentucky Oaks. A daughter of Uncle Mo, she took a little while to get good, but started to put things together when winning a Jan. 7 maiden at Santa Anita by 12 lengths. With two straight Beyer numbers of 94, she has the top figures so far among any of the fillies eyeing the Kentucky Oaks.

4) KATHLEEN O. (Upstart–Quaver, by Blame) O-Winngate Stables, LLC; B-Gainesway Thoroughbreds Ltd. & Bridlewood Farm (KY); T-Shug McGaughey. Sales History: $8,000 wlg '19 KEENOV; $50,000 ylg '20 OBSOCT; $275,000 2yo '21 OBSAPR. Lifetime Record: GSW, 3-3-0-0, $226,280. Last Start: 1st GII Davona Dale S. Next Start: GII Gulfstream Park Oaks, GP, Apr. 2. KY Oaks Points: 50.

She's 3-for-3 and has been visually impressive in each of her starts. She passed a big test last out when beating graded company for the first time in the GII Davona Dale S., which she won by two lengths. She takes her time to get going in her races, but when she does she launches a kick that is something to see.

Hard to imagine she originally sold for just $8,000 at the 2019 Keeneland November sale before selling for $50,000 at the OBS October Yearling Sale and then for $250,000 at the 2021 OBS April Sale.

She'll stretch out from a one-turn mile to a two-turn mile-and-sixteenth Saturday in the GII Gulfstream Park Oaks, but that doesn't figure to be a problem. If anything, the two turns and the longer distance should result in an improved effort. On the Beyer scale, she's improving. Went from a 67 in debut to a 78 in the Cash Run S. to an 85 in the Davona Dale. She'll need to up her numbers to win the Kentucky Oaks, but no reason why an improving filly in the hands of Hall of Fame trainer Shug McGaughey can't do just that.

5) NEST (Curlin–Marion Ravenwood, by A.P. Indy) O-Repole Stable, Eclipse Thoroughbred Partners & Michael House; B-Ashview Farm & Colts Neck Stables (KY); T-Todd Pletcher. Sales History: $350,000 ylg '20 KEESEP. Lifetime Record: GSW, 4-3-0-1, $265,000. Last Start: 1st Suncoast S. Next Start: GI Central Bank Ashland S., KEE, Apr. 8. KY Oaks Points: 20.

Trained by Todd Pletcher, Nest is the winner of last year's GII Demoiselle S. at Aqueduct, which has emerged as a key race. Nest came back to win the Suncoast S. at Tampa Bay Downs and runner-up Venti Valentine (Firing Line) won the Busher S. at Aqueduct. Magic Circle (Kantharos) also emerged from that race to win a stakes and Nostalgic (Medaglia d'Oro) recently romped in an allowance race at Gulfstream. Nest won the Demoiselle by just a neck, but obviously beat some good horses. Didn't prove much when beating inferior rivals as the 3-10 favorite in the last, but did what was required of her.

Goes next in the GI Ashland S. at Keeneland, which will be a much tougher test. This is a good one. Very much a contender to win the Kentucky Oaks.

6) HAPPY SOUL (Runhappy–Cowgirl Lucky, by Stephen Got Even) O-Gayla Rankin; B-Harris Training Center, LLC (KY); T-Wesley Ward. Sales History: $50,000 ylg '20 KEESEP. Lifetime Record: MSW, 4-3-1-0, $238,500. Last Start: 1st Dixie Belle S. Next Start: Next Start: GI Central Bank Ashland S., KEE, Apr. 8. KY Oaks Points: 0.

Wesley Ward certainly knows what he is doing and he is confident that this very fast daughter of Runhappy can stretch her speed around two turns.

“We're going to take it one race at a time and see how she runs in the Ashland before deciding on the Kentucky Oaks,” Ward said. “She had an awesome work over the Keeneland main track (six furlongs in 1:12) the other day. [Exercise rider] Julio Garcia was beaming after the work. He was going crazy when he got off her.”

The Ashland will be a huge test. Even though Happy Soul has won her last three starts by a combined 26 1/4 lengths, she's never gone beyond six furlongs. Has a ton of ability. The distance is the only question, and it's a big one.

7) HIDDEN CONNECTION (Connect–C J's Gal, by Awesome Again) O-Hidden Brook Farm & Black Type Thoroughbreds; B-St. Simon Place (KY); T-W. Bret Calhoun. Sales History: $49,000 RNA wlg '19 KEENOV; $40,000 ylg '20 KEESEP; $55,000 RNA 2yo '21 OBSAPR; $85,000 2yo '21 OBSOPN. Lifetime Record: 5-2-1-0, $399,525. Last Start: 2nd GII Twinspires.com Fair Grounds Oaks. Next Start: GI Longines Kentucky Oaks, May 6, Churchill Downs. KY Oaks Points: 57.

She dropped off the list after finishing fourth in the GII Rachel Alexandra S. in her 3-year-old debut. After losing by just a nose to champion Echo Zulu in the Fair Grounds Oaks, she is back. Showed a new dimension in the Fair Grounds Oaks, closing from fourth after taking the early lead in her prior start. But…was she that good or did Echo Zulu put in a sub-par performance?

Showed a lot of promise last year when winning the GIII Pocahontas S. by 9 1/4 lengths, but didn't back that up when a distant fourth in the Breeders' Cup Juvenile Fillies. Probably not quite as talented as the top three or four on this list, but is a solid filly, a graded stakes winner and is in the capable hands of trainer Bret Calhoun.

8) VENTI VALENTINE (Firing Line–Glory Gold, by Medaglia d'Oro) O-NY Final Furlong Racing Stable & Parkland Thoroughbreds; B-Final Furlong Racing Stable & Maspeth Stable (NY); T-Jorge Abreu. Lifetime Record: MSW & GSP, 4-3-1-0, $366,250. Last Start: 1st Busher Invitational S. Next Start: GIII Gazelle S., AQU, Apr. 9. KY Oaks Points: 54.

Will look to give up-and-coming trainer Jorge Abreu his first graded stakes win. A native of the Dominican Republic, Abreu has been training only since 2016 and had his best year ever when his stable earned over $2 million in 2021. Abreu has served as the assistant to John Terranova, Nick Zito and Chad Brown.

This New York-bred filly won a pair of state-bred races last year before losing by just a neck to Nest in the Demoiselle. She followed that up with a blowout seven-length win in the Busher S., which was a tougher spot than one would ordinarily expect from a non-graded race. In most any other year would be a top three or four contender for the Kentucky Oaks, but not among this loaded group.

9) SHAHAMA (Munnings–Private Feeling, by Belong to Me) 'TDN Rising Star' O-KHK Racing; B-SF Bloodstock LLC (KY); T-Todd Pletcher. Sales History: $425,000 2yo '21 OBSAPR. Lifetime Record: GSW-UAE, $223,670. Last Start: 1st G3 UAE Oaks. Next Start: GI Longines Kentucky Oaks, May 6, Churchill Downs. KY Oaks Points: 50.

Arrived in the Pletcher barn after winning the GIII UAE Oaks on Feb. 18 for trainer Fawzi Nass and owner KHK Racing. Is 4-for-4 in her career, with all her races coming in Dubai. Half-sister to champion Lookin At Lucky (Smart Strike) sold for $425,000 last year as a 2-year-old at OBS April. Really hard to get a read on her. Cost a lot and obviously has some talent, but there's no telling how the competition she faced in Dubai stacks up to what she'll meet in the Kentucky Oaks. Is going to have to be very good to beat the kind of field she is set to face at Churchill Downs.

10) CLASSY EDITION (Classic Empire–Newbie, by Bernardini) 'TDN Rising Star' O-Robert E & Lawana L Low; B-Chester & Mary R. Broman (KY); T-Todd Pletcher. Sales history: $550,000 2yo '21 FTMMAY. Lifetime Record: MSW & GSP, 4-3-1-0, $223,450. Last Start: 2nd GII Davona Dale S. Next Start: GIII Gazelle S., Aqu, Apr. 9. KY Oaks Points: 20.

The third of three Pletcher-trained fillies to make the list. Bought for $550,000 at the Fasig-Tipton Midlantic 2-year-old sale, the filly showed something when second to the highly regarded Kathleen O. In the Davona Dale. Another New York-bred, she has never run beyond a mile or around two turns, so the Gazelle at nine furlongs, should be a good test for her. Appears to be on the improve, but needs to show more to win the Kentucky Oaks.

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Thursday Racing Insights: Mandy Pope Starts Pair At Oaklawn

Sponsored by Alex Nichols Agency

4th-OP, $90K, Msw, 3yo/up, f, 1 1/16m, 3:33 p.m.

A pair of fillies represent Mandy Pope's Whisper Hill Farm at Oaklawn Park Thursday, including DANCE IT (Tapit), a 3-year-old purchased for $500,000 from the 2020 Keeneland September Yearling Sale. Out of the unraced Forestry mare Redwood Dancer, herself from the extended family of champion 2-year-old Flanders (Seeking the Gold) and MGIW Air Force Blue (War Front), Dance It is a half-sister to GIP and SW The Virginian (Aus), along with three other winners from as many to race. She makes her career debut here going two-turns after a consistent work log at the Fair Grounds, including a five-furlong drill from the gate in :59 3/5 Mar. 9. Dance It gets Lasix for her first start, and jockey Joel Rosario picks up the ride for trainer Steve Asmussen.

Making her third career start for Whisper Hill is GOLDENA (Medaglia d'Oro), who brought $300,000 at the 2019 Keeneland September Yearling Sale. While she has an age and experience advantage over her stablemate, the 4-year-old will need to move forward from her first two starts, a disappointing 10th going six-furlongs Jan. 7 and a distant seventh Feb. 13 at 1 1/16 mile, both at Oaklawn. Her works have notably picked up in intensity since her most recent start, including a five-furlong work in 1:00, the fastest of 12 at the distance Mar. 21. Goldena also worked four-furlongs in :48 1/5 Feb. 28 to post the quickest time of 63. She adds blinkers Thursday for trainer Jerry Hollendorfer. TJCIS PPs

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Patch Reduces Attraction Of Flies To Horses

Equiwinnerâ„¢, an electrolye-balancing treatment that is best known for resolving and prevention of anhidrosis (non-sweaters) and exercise-induced pulmonary hemorrhage (EIPH), can also reduce the attraction flies have to horses, it has been recently shown.

“In the same way that sweat, manure and urine attract flies, so too, do improperly balanced fluids,” said Barbara Socha of Signal-Health, the North American distributer of Equiwinner. “Because improperly balanced fluids in skin moisture or bodily secretions actually attract flies, particularly fluid exuding from the eyes, when the electrolytes are balanced and working properly, it can deter flying insects.”

Deanna Searles, an AQHA trainer who has used Equiwinner for more than four years for horses that have trouble sweating in the summer heat of Scottsdale, Arizona, has noticed over time that her horses treated with Equiwinner patches have significantly less flies and bugs bothering them than their herd mates.

“Recently we tried Equiwinner on a horse that had tons of flies–just swarms of flies on his neck on both sides,” said Searles. “After using the Equiwinner patches for 10 days, the flies don't seem to bother him anymore.”

For additional information, click here.

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Letter to the Editor: Joseph S. Bertino, Jr., PharmD, FCP, FCCP

I am writing to try to clear up some of the confusion concerning the science around betamethasone as it pertains to its use in racehorses. I am a (human) clinical pharmacologist and the Editor-in-Chief of the Journal of Clinical Pharmacology.

Why are there different forms (salts) of betamethasone (in this case acetate and valerate)?

Many drugs do not dissolve well in water, so other molecules are added to them so that they can dissolve in water in order to make useful dosage forms. Sometimes these other molecules are added to the drug to make them last longer in the animal when injected into something like a joint, that is, dissolve very slowly (think of a slow-release drug). Often, the betamethasone used to inject into a joint has two forms, one that is already dissolved to act sooner and one that remains in the joint and delivers [the] drug more slowly. For use on the skin, betamethasone valerate is used and can be absorbed into the animal. Betamethasone from any of these salts is the same in the animal's body; it's a potent drug used to reduce inflammation and pain and its effect is long lasting in any form.

What happens to these other molecules added to betamethasone?

The body removes these extra molecules added leaving the main drug (in this case betamethasone) to do its work. For betamethasone valerate in an ointment, some of it will be absorbed and the amount depends on the integrity of the area it is being applied to. The valerate added to betamethasone would be found in the urine along with some betamethasone valerate. For betamethasone acetate, the acetate is removed and used in the body to make other things so finding it in the urine would be quite unusual.

How does a drug like betamethasone work to reduce inflammation and pain?

Inflammation occurs due to the animal's immune system working and its reaction to an injury. The drug acts to calm down the immune system to produce its effect. Betamethasone in any salt form does not work immediately when injected in a vein, a joint, or applied as an ointment. This effect takes time to occur (at least a few hours after the animal gets the drug). Even when the drug is completely gone from the body, the effect remains for some time (hours or days) because it takes the immune system time to gear back up (and hopefully the injury is healed). So that means even if small amounts or no drug is found in the blood, the effect on inflammation and pain lingers after a dose.

Do we know the relationship of the amount found in the blood and the drugs' effect on reducing inflammation and pain?

Absolutely not, we do not know how much drug in the blood is needed to get the effect to reduce inflammation and pain. Measurement of the drug in blood is not a good indicator of the dose of the drug used or when the drug was given; it simply tells us that the animal has received the drug. This is the reason that there is such a long time between injection of the drug into a joint and when a horse can race “clean” as set up in the rules of a racing commission.

What can measurement of drug in the blood tell us?

Measurement of drug in blood can tell us how much total drug can be found in the blood of the horse but not how much total drug is in the body of the horse. For Medina Spirit, a measurement of 21 pg/mL in the blood was found the day he won the 2021 Kentucky Derby. The average blood volume of a horse is 54.5 liters (54,500 mL or 12.3 gallons). So, if you multiply 21 pg/mL x 54,500mL of blood, you get 1.14 micrograms total in the blood. The usual dose injected into a joint in a horse is 9 mg (9,000 micrograms), and since the betamethasone acetate used is designed to dissolve slowly, we would suspect that there could be more drug remaining in the joint than what is reflected in the blood.

So, what does this all mean? 

Well first, betamethasone is betamethasone, it doesn't matter how it got into an animal (injection, ointment, etc.), it is active in reducing inflammation and pain. Next, finding low amounts of the drug in the blood does not tell us when the drug was last given. It does tell us that an exposure has occurred and may be ongoing. Since the drug effect is long lasting (and lasts even after the drug concentration is low or no longer measurable in the blood), a significant effect on inflammation and pain may still be occurring. Finding betamethasone valerate in the urine is not unexpected when betamethasone valerate is used as an ointment [as] some is absorbed. When using betamethasone acetate injection, finding no acetate in the urine is expected because the body uses the acetate that is shaved off the betamethasone to make other things.

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