Inbreeding Contributes To Mid- And Late-Term Pregnancy Loss In Thoroughbreds

New research from the Royal Veterinary College (RVC), in collaboration with Cornell University, has found that inbreeding is a contributing factor to mid- and late-term pregnancy loss (MLPL), but not early pregnancy loss (EPL) in thoroughbreds. This is the first study which explores the effect of genomic inbreeding levels on late-term pregnancy loss in the horse and will help inform mating choices to minimise the risk of miscarriages in thoroughbreds.

Inbreeding is a common practice in the livestock industry because individuals with desirable traits are highly prized for breeding. However, excessive inbreeding is known to increase the probability of uncovering homozygous recessive genotypes which have previously been associated with an increased risk of retained placenta and lower semen quality in horses.

Approximately five to 10 per cent of equine pregnancies end in early pregnancy loss and a further seven percent of pregnancies are lost between day 70 of gestation and 24 hours post parturition (MLPL). However, to date, there has been no definitive analysis to investigate the association between genomic inbreeding levels and pregnancy loss in horses.

Therefore, the research team, led by Dr Jessica Lawson, Alborada Trust research fellow at the RVC, and Professor de Mestre at the Baker Institute for Animal Health at Cornell University, together with previous PhD student at the RVC, Charlotte Shilton, analysed DNA samples from 189 individuals, including a control group. The study found that thoroughbred pregnancies lost in mid and late gestation (MLPL) had significantly higher inbreeding metrics than UK thoroughbred adults. However, pregnancies lost early in gestation (EPLs) showed no significant difference in inbreeding metrics compared to the adults.

Dr Jessica Lawson said, “This research provides critical evidence showing that mating highly related individuals does have a tangible effect on our breeding operations, as there is a real risk of a mare losing her pregnancy late in gestation and failing to produce a foal at all that season.

“The take home from our work should be to carefully consider breeding choices that involve mating of highly related individuals as, ultimately, this may increase the chance of the foal inheriting mutations which may not be compatible with life. We are already working on the next step, looking to identify these changes so more specific advice can be provided in the future”.

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‘State Man Must Win’ – Q&A With Haras de Saint-Voir Boss Nicolas de Lageneste

There are few more respected figures in French National Hunt racing than Nicolas de Lageneste. 

It seems as though everything de Lageneste turns his hand to, be that breeding, training or simply owning racehorses, it is a success.

Last year he completed the rare achievement of being crowned champion National Hunt owner and breeder in the same season. Nobody has ever done that before. 

Fewer still would be capable of nurturing a horse like Il Est Francais (Fr) (Karaktar {Ire}). Not only did de Lageneste breed the superstar chaser, who could be on course for next year's Gold Cup, but he also sourced the stallion, Karaktar, who is tipped to be the next big thing in National Hunt racing in France. 

The cherry on top is the fact that Haras de Saint-Voir remain involved in the ownership of Il Est Francais, who de Lageneste compares favourably with former star graduate Vautour (Fr) (Robin Des Champs {Fr}).

De Lageneste has built up a particularly strong relationship with Champion National Hunt trainer in Ireland Willie Mullins in recent years and Tuesday's short-priced Champion Hurdle favourite State Man (Fr) (Doctor Dino {Fr}) will be bidding to fly the flag for Haras de Saint-Voir on the big stage again.

From breeding top-class National Hunt stallion Saint Des Saints (Fr), to his association with Mullins and his hopes for Cheltenham and beyond, de Lageneste makes for a fascinating Q&A.

State Man: will fly the flag for de Lageneste in the Champion Hurdle | Racingfotos.com

You became the first person in French National Hunt history to be crowned leading breeder and owner in 2023. What did that mean to you?

It gave me great satisfaction and in many ways it was a consecration of our breeding at Haras de Saint-Voir.

I can only imagine that Il Est Francais (Fr) (Karaktar {Ire}) was the highlight of last year for you. He was sublime at Kempton. How difficult of a decision was it to bypass Cheltenham with him or was the Grand Steeple Chase de Paris always Plan A?

For over two years now the plan has always been to run and try to win the Grand Steeple Chase de Paris. He has never had to fight in a race and we thought that he needed to be battle hardened in order to run in a Cheltenham Gold Cup. We have respected him since the beginning of his career, knowing that he was outstanding and a horse for the biggest challenges. Who knows what next year will bring. 

Assuming all goes well at Auteuil, what could be in store for the horse next year? I presume the King George and the Cheltenham Gold Cup will come under consideration?

Exactly. He will go back to Kempton in December and if everything keeps going well for him, we could think about that great expedition in March 2025. 

You are famous for taking a chance on little known sires and making them famous. Tell us a little bit more about why you decided to back Karaktar (Ire)?

I like to buy stallion shares when I am impressed by horses on the track. Karaktar had been so impressive at the beginning of his three-year-old career before running in the French Derby and showed great ability and fantastic movement. He got hurt in the French Derby but Alain de Royer Dupré, a great horseman, liked him so much and was still thinking about the Arc de Triomphe for him. Unfortunately, he met with another problem and his trainer never found a way to get him back. We bought him for €110,000 in a sale for horses-in-training and he has turned out to be a great success. I sent him some good mares for the first season and I am rewarded today. When you really believe in something, give it your all for the chance to be successful. That's my approach to breeding. Karaktar is for sure going to be the next top National Hunt stallion in Europe, as his book of mares has been improving a lot in only the last two seasons, and he covered 243 mares last year.

Most people will know you as the breeder of Saint Des Saints. He is making a pretty emphatic mark on the National Hunt breed. That must provide you with huge satisfaction?

Oh yes. That's another great satisfaction. I had bought the mare of Saint Des Saints for about €2,000 in a liquidation sale in a supplement of a catalogue at 9pm in Deauville. She was a Group 2 winner but was quite old and had a poor career as broodmare. She was a bad milker and, unfortunately, many of her foals died. However, she was from one of the great French thoroughbred families (highlighted by de Chambure's family). Saint Des Saints showed on the turf that he was the best four-year-old in France before getting a virus in May of that campaign and that probably weakened him. However, the genetic potential was there and we are delighted to see that he is today a successful sire of sires and probably the best National Hunt sire of broodmares.

Looking ahead to Cheltenham next week, what graduates of yours are you most looking forward to and why? State Man winning a Champion Hurdle would be very special.

State Man is a short-priced favourite in the Champion Hurdle and he must win. He is trained by the best National Hunt trainer in Europe and comes from the breeding of Guy Cherel who is a perfect horseman, breeder and trainer. Not to mention that State Man's dam was class at Auteuil, a tough mare, and his sire Doctor Dino is probably the best National Hunt stallion in France. Put the best with the best and you will have more chances to be among the best. Apart from State Man, I will not have a lot of runners at Cheltenham as my policy is now to try to keep my horses in France. French breeding will definitely be successful this year at Cheltenham, though. One of the reasons is that we breed horses more for the track than the sales ring. We use stallions with a National Hunt profile in the first choice and we are lucky to stand very good French stallions for that discipline. 

You must have many fond memories from Cheltenham? Would Vautour rank as the most spectacular horse you have bred? He was awesome when winning the Ryanair Chase.

Yes, Vautour really was a great horse, really impressive in all his Cheltenham victories. He was a potential Gold Cup winner and his premature end was very sad for everyone involved. He was an amazing jumper, such a natural, and it was a great thrill to see him flying over his fences. I have found some similarities in his own way of jumping with how Il Est Francais jumps as well.

Tell us a bit more about your relationship with Willie Mullins. He has trained a lot of excellent horses that you have bred. How has that relationship developed?

Willie is just the best. An amazing man. I am a long-time good friend of Pierre Boulard, who used to buy for Willie and when I have a horse who could be exported, Willie has the first preference. We have full confidence with Willie. I have visited him twice and was very impressed by the quality of his training, by his gallops and by his staff. I am drawn by his humanity and humility. 

I understand that Willie and Jackie Mullins have a few mares in partnership with you, including a half-sister to Benie Des Dieux (Fr) (Great Pretender {Ire}). That must be exciting.

I take care of a few mares owned by Jackie and when the owner of Grace Des Dieux (Fr) (Blek {Fr}) [a half-sister to Benie Des Dieux) asked me to buy her, as he knew that I loved the family, I thought that this mare might please Jackie. She immediately agreed and we bought the mare in partnership. The first produce is for Jackie, a very good colt by Great Pretender. She is in foal to Karaktar and is due on April 1. The second foal is mine and that is very exciting. I am very much enjoying this venture with Willie and Jackie. 

You have a soft spot for Ireland and have been there many times. What is it about Irish racing and bloodstock that you like so much?

I like the atmosphere in Ireland and love Irish people. I feel well over there with some good friends I like to meet. It's a country I would have loved to live in.

It's not all about National Hunt racing for you. You have also had some fun on the Flat and Knock On (Fr) (Zelzal {Fr}) won a Listed race for you last October. What are the plans for her this year?

I stand with only one Flat mare by Acclamation (GB) and I have a share in Zelzal (Fr) as well. So the cross is simple each year, and has been successful with J'Acclame (Fr) (Zelzal {Fr}) [five wins in Longchamp and Chantilly] and Knock On [Listed winner and Listed-placed]. Knock On could go for Listed races over less than a mile. She is very easy and quiet in the morning, but on the track she is a lion with a lot of speed.

Finally, despite your huge success, you have never forgotten your roots and you remain closely connected to the grassroots of your sport in France. What is your philosophy to racing and breeding and what advice would you impart on others?

When I took the management of the stud at the beginning of 1990s, we worked hard, standing stallions-usually four-and improved each year our genetics in broodmares. This period was difficult but we have learned our job as breeders. When I stopped standing stallions, I invested a lot to improve the land and select the mares, and today we are hopefully reaping the benefit of all these years of work. Nothing happens by itself. I can't pretend to teach others as I myself learn everyday something new about horses. My principal advice can be to always keep [one's] humility and stay observant.

 

 

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‘I Wouldn’t Swap Him’ – Hannon Has Confidence In Guineas Hope Rosallion

Richard Hannon has said there is not one horse that he would swap Rosallion (Ire) (Blue Point {Ire}) for and reported the Group 1 winner to be firmly on course for the 2,000 Guineas at Newmarket on May 4. 

Previously described as “right up there with the best we've ever had” by his handler, Rosallion is a general 8-1 chance for Classic glory at Newmarket. 

His big day in the sun last year came when storming to G1 Prix Jean-Luc Lagardere glory and confidence is clearly high in the camp that Rosallion can give short-priced 2,000 Guineas favourite City Of Troy (Justify) something to think about. 

Hannon said, “Rosallion is in great form and he's had a canter upsides Haatem (Ire) (Phoenix Of Spain {Ire}) on the grass. Timmy Murphy rides him every day and was delighted with him. It wasn't a massively informative piece of work but it was just one of those where we thought we would give him a little bit while it was a nice morning and the grass is nice.”

He added, “I would like to give him a trial, but I won't run him anywhere where there is soft ground. He could just go straight to the 2,000 Guineas. I'm going to take him to either Kempton or Newbury two or three weeks before the trials, so if he does go straight to the Guineas, he will be plenty quick enough. My view of him hasn't changed–there is not a horse I would rather have other than him.”

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Seven Days: Jumping Back to the Flat

Yes, I know. It's a bit early for this, isn't it? We usually have a strict No-Seven-Days rule until the week after the Brocklesby but this winter has dragged on and on and I just can't wait any longer.
We have the small matter of the Cheltenham Festival to get through this week, and we'll be giving it our full attention, but as we have counted down the days to the 'The Roar' it has been impossible to ignore the sneaky French getting their Turf season underway with a couple of Listed races at Saint-Cloud. And what better way to usher the Flat back in than with last season's Poule d'Essai des Poulains winner Marhaba Ya Sanafi (Ire) exhibiting that he retains plenty of zest for racing with his victory in the Listed Prix Altipan? We may see him back in action as soon as the G3 Prix Edmond Blanc on Easter Monday as he gears up for a tilt at the G1 Prix d'Ispahan.
Marhaba Ya Sanafa's sire Muhaarar (GB) is now ensconced in his new home of Haras de Petit Tellier and has already been represented this year by the G2 1351 Turf Sprint winner Annaf (Ire) on Saudi Cup night.
On the subject of returning Classic winners, Serpentine (Ire) (Galileo {Ire}) won Saturday's Listed Randwick City S. for Gai Waterhouse and Adrian Bott to claim his first stakes success since that extraordinary romp in the 'Covid' Derby at Epsom in 2020. It's almost unheard of for a Derby winner still to be in training at the age of seven, let alone to have been gelded.

Flags Flying High for Zoffany

Coolmore lost Zoffany (Ire) three years ago when he succumbed to liver failure at the age of just 13 ahead of the start of the 2021 covering season. Members of his final crop are now three, and they include the Jerome Reynier-trained Fun With Flags (Ire), who kept Classic hopes intact for her owner Erika Gilliar by claiming her third successive victory in the Listed Prix Rose de Mai.
Out of the Galileo (Ire) mare Marie Celeste (Ire), Fun With Flags was bred by Sonia Rogers from a family which has been at Airlie Stud for three generations and traces back to Rough Shod (GB) (Gold Bridge {Fr}) through her celebrated daughter Thong (Nantallah). The latter is in turn the dam of Special (Forli), whose offspring include Nureyev (Northern Dancer) and Sadler's Wells's dam Fairy Bridge (Bold Reason).
With entries in the Poule d'Essai des Pouliches and Prix de Diane, Fun With Flags is one to follow as she attempts to become a Classic winner from her sire's farewell crop. She would be the first for her prolific trainer Reynier, who is currently behind only reigning champion Jean-Claude Rouget in the French trainers' table.

Listed Double for Scott at Home and Away

On Thursday it was a Dandy Man (Ire) gelding out of a Dark Angel (Ire) mare out in front in the Listed Spring Cup at Lingfield and 24 hours later the reverse of that cross was seen to good effect at Chantilly in the Listed Prix Maurice Cauillault.
Watch My Tracer (Ire) was the Dandy Man three-year-old in question, and he set up a thrilling 24 hours for his trainer George Scott and owners Victorious Racing with his debut success of the year, which was followed the next day by the triumph of Isle Of Jura (GB) (New Approach {Ire}) in the King's Cup in Bahrain.
That second Listed win was hailed by Scott as “the highlight of my career to date, miles ahead of anything else”, and it is easy to see why he would be walking on air after the winter campaign his four-year-old has had in Bahrain. Having won twice at Newmarket and Newbury last summer in for his Bahraini owners, Isle Of Jura travelled to the Gulf to compete in Bahrain's lucrative turf series and he has been a near-unstoppable force there, winning four of his five starts, including two Listed races, and finishing second, beaten a short-head, on his only other run. Pattern company back in Europe now beckons for the Godolphin-bred gelding, who is a full-brother to the treble Australian Group 1 winner Cascadian (GB).
The aforementioned Prix Maurice Cauillault was yet another strike for Jerome Reynier, trainer of the easy winner Darlinghurst (Ire), who was bred by Yeomanstown Stud and, as noted, is by their kingpin Dark Angel. It was the second stakes winner of the day for the 19-year-old stallion after Godolphin's Real World (Ire) landed the Listed Al Methaq Mile in Bahrain.

Donworth Goes Dutch

There is nothing like seeing the Chateau de Chantilly in the backdrop of races to make one feel that life is again worth living and, though Friday's card was on the Polytrack, it provided plenty of interesting pointers for the season ahead.
There won't be many Dutch-bred stakes winners this year (or ever), but Tim Donworth, once of the parish of Roundhill but now a fully assimilated French dweller, saddled the Listed Prix Montenica Skylight Brochard (Hol) who may remain unique in that regard this year.
“I think he's probably the only Thoroughbred who's been bred in Holland in the last couple of years,” Donworth told TDN. “It's worked out great. His breeders happened upon the mare, they'd never had a horse before and they've now bred this horse.”
The son of Mehmas (Ire) was bred by his owner Jill Brochard and is a full-brother to eight-time winner The Covex Kid (Ire). Their dam is Fonseca (Ire), by the late Red Clubs (Ire) who has a notable record as a broodmare sire despite his having stood for only three seasons before dying at the age of seven. His daughters have produced the Group 1 winners Lucky Sweynesse (NZ), Snow Lantern (GB) and Lezoo (GB), as well as the useful sire and Group 2 winner Ardad (Ire), Group 3 winner Spycatcher (Ire), last season's Lincoln winner Migration (Ire) and the Listed-winning half-siblings Arthur Kitt (GB) and Eartha Kitt (GB).

Like Mother, Like Son

Perhaps the largest scribble in the notebook from Friday in Chantilly was the name Dolayli (Fr) after the running of the Prix Darshaan. The Aga Khan Studs-bred son of Siyouni (Fr) and Group 1 winner Dolniya (Fr) (Azamour {Ire}) has won six of his eight starts, including all three of his runs this year for Francis Graffard. It is a rare Aga Khan runner that remains in training at five, but Dolayli may well repay his owner further as he is aimed at classier assignments through the spring and summer. His trainer told the Jour de Galop that he is looking at the G2 Prix d'Harcourt and considering the Ganay and perhaps even the Ispahan as potential Group 1 targets. Dolayli had the G1 Hong Kong Vase winner Junko (GB) (Intello {Ger}) five lengths behind him in second as the latter winds up for a shot at the G1 Dubai Sheema Classic later this month.
It seems scarcely believable that it is nine years since Dolayli's dam Dolniya took the Sheema Classic herself after she too had won the Prix Darshaan, each time beating Flintshire (GB). She is now the dam of three black-type offspring, including Group 3 winner Dilawar (Ire) (Dubawi {Ire}) and Listed-placed Dolia (Fr) (Invincible Spirit {Ire}). Her current two-year-old is an unnamed Frankel (GB) colt who is also assigned to Graffard.

Heating Up

Darley's second-season sire Too Darn Hot (GB) has four colts and two fillies entered for the 2,000 and 1,000 Guineas in May, and he may well have a Classic hope even farther afield following the victory on Sunday of Etes Vous Prets in the G2 Hochi Hai Fillies' Revue at Hanshin. The daughter of G1 Falmouth S. winner Nahoodh (Ire) (Clodovil {Ire}) was bred by Godolphin and exported as a yearling to Japan, where she races in the colours of Sheikh Hamdan bin Mohammed Al Maktoum.
She is the fifth Group/Graded winner in a fourth different country for Too Darn Hot following Fallen Angel (GB), Darnation (GB), Alyanaabi (Ire) and Carolina Reaper (GB).

A Fitting 19th G1 Winner for Exceed And Excel

In the week in which the retirement was announced of successful shuttle sire Exceed And Excel (Ire) there could have been no more appropriate winner of the G1 Newmarket H. at Flemington than his son Cylinder (Aus). The Godolphin homebred became his sire's 19th Group/Grade 1 winner in the race won by Exceed And Excel 20 years ago. Following that victory he was bought by Sheikh Mohammed and became a valuable addition to the Darley stallion ranks on both sides of the globe.
We may yet see Cylinder racing in Europe, with Godolphin Australia's Nacim Dilmi suggesting after his victory that a trip to Royal Ascot in June could now be on the cards.

 

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