Study on the Impact of Training on Bone Robustness in Racehorses

University of California Davis released new research in the journal Scientific Reports exploring the relationship between training and bone health in racehorses in the US. The study reports that high-speed and intensity exercise may be associated with more damage and reduced robustness in injured lower leg bones in racehorses.

Among the findings, UC Davis's Sarah Shaffer and her colleagues explored the relationship between exercise and bone damage, while examining the proximal sesamoid bone (a bone in the lower leg) during the necropsy of 20 racehorses. The authors examined the fractured and intact proximal sesamoid bones from 10 horses who had suffered fatal fractures. They compared the bone mineral density, bone volume, and microdamage in this sample to intact proximal sesamoid bones of 10 control horses. Case horses had a bone lesion with high levels of microdamage and low bone volume. These observations were used to estimate the rate of remodeling occurring in the sesamoid bones.

The authors also modeled the relationship between bone damage and remodeling, and exercise intensity, time off from exercise (layups), and exercise levels between two and 10 months before the racehorse died. For injured horses, damage at the lesion site was associated with high-speed workouts in the four months prior to death, as well as greater time between races while the horse was in active training. Frequent high-speed exercise before death was also associated with lower bone density at the lesion site. However, at other locations, higher rates of remodeling were associated with more cumulative races in the 10 months prior to death.

To view the complete study, click here.

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Make It Big Battles Osbourne Through Stretch To Take Springboard Mile

Make It Big earned 10 qualifying points in the 2022 Kentucky Derby standings Friday night, winning the $401,200 Springboard Mile for 2-year-olds at Remington Park in Oklahoma City, Okla.

The top 2-year-old race of the Remington Park season provided the stage for the third win in a row to start the career of Make It Big, who has never raced on Lasix. Kentucky Derby points are awarded to horses only if they have not raced on the diuretic during the qualifying races. The other horse earning points in the Springboard was runner-up Osbourne, who gets four in the Derby standings. The third and fourth place finishers, Concept and Classic Moment, both from trainer Steve Asmussen's barn, competed with Lasix on Friday night.

Rick Sacco, racing manager for Make it Big's owner, Red Oak Stable in Ocala, Fla., was non-committal on where Make It Big's first start as a 3-year-old will be in 2022, but the dark bay colt by Neolithic, out of the Congrats mare Ruby on My Mind, won his first two races at Gulfstream Park in Hallandale Beach, Fla. The $120,000 purchase at the Ocala Breeders Sale Spring Sale of 2-year-olds in training has quickly earned his keep. He won $240,000 from the purse Friday and is now undefeated through three attempts with total earnings of $303,828.

“Yes, we will enjoy these Kentucky Derby points,” said Sacco, “but we will have to discuss where we send him next.”

Sarah Shaffer, trainer Saffie Joseph, Jr.'s assistant, was on hand for the victory, just having met the horse for the first time this week. She stables at the Fair Grounds in New Orleans, La.

“He has a personality and a half,” she said. “We expected the cold weather to sharpen him up here.”

Temperatures were brisk in the high 40s when seven horses broke from the gate for the Springboard. Make It Big was feeling his oats in the warmup. Jockey Jose Ortiz was putting everything he had to keep the colt in his skin before the race.

“We really wanted to get him warmed up,” said Shaffer. “He's very smart. He knew what he was here for. Nice horse.”

Make It Big broke his maiden on Oct. 9 at Gulfstream, winning by 8 1/2 lengths at first asking. He then took down the $60,000 Ocala Stud Juvenile Sprint Stakes for Florida-breds at Gulfstream by 2 1/4 lengths on Oct. 30. Both of those wins came at seven furlongs and with jockey Edgard Zayas in the saddle. Friday night's Springboard was his first trip around two turns.

“The horse was two-for-two with Edgard,” said Ortiz, who shipped in from the East Coast for the mount. “Unfortunately, Edgard couldn't ride because he had to have surgery on his shoulder.”

Ortiz, the No. 4 rider in the country with his horses earning more than $24 million in 2021, wasn't a bad substitute and he rode Make It Big to perfection. He took the winner's circle photos with the garland of flowers wrapped around his shoulders from head to near his feet.

Ortiz let Make It Big settle in fifth down the backstretch and then asked for a run at the top of the stretch. By that time the colt was rolling and he engaged Osbourne who took the lead before the field left the final turn. Make It Big battled neck and neck with Osbourne throughout the length of the stretch, gaining a half-length win at the finish.

Osbourne is trained by Ron Moquett of Breeders' Cup Sprint winner fame, Whitmore. Osbourne, a 2-year-old gelded son of Tapiture, out of the Rock Hard Ten mare Planet Rock also has not raced on Lasix in three tries. He broke his maiden in his last start at Churchill Downs in Louisville, Ky., on Nov. 17 at seven furlongs. Julien Leparoux, his regular rider, fought gamely from the outside post position in the field of seven. He was three lengths ahead of third-place finisher Concept, winner of the $75,000 Kip Deville Stakes on Sept. 26 at Remington.

The remaining order of finish in the Springboard was Classic Moment (4th), Rowdy Rascal (5th), Revenir (6th), and Bye Bye Bobby (7th).

Make It Big was sent off at 6-5 odds as the betting favorite and paid $4.60 to win, $3.40 to place, and $2.60 to show. The winner cut into early fractions of :24.77 for the first quarter-mile, :49.22 for the half-mile, 1:14.94 for three-quarters of a mile, and 1:27.86 for seven furlongs. His winning time at the mile was 1:41.23 over the fast main surface.

Make It Big is doing his best to put his young sire, Neolithic, on the map. That stallion went to stud in 2018 and Make It Big was foaled in 2019. Neolithic has some classic bloodlines, being a son of Harlan's Holiday, and his stud fee might soar if this horse proves to be worthy on the Kentucky Derby trail. Neolithic's stud fee for 2022 is $5,000 for a live foal. Harlan's Holiday won $3.6 million in his racing career, including Grade 1 wins in the Florida Derby, the Blue Grass Stakes, and the Donn Handicap.

Make It Big is easily Neolithic's top earner among his progeny.

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Study Links Bone Loss To Proximal Sesamoid Bone Fractures In California Racehorses

A recent study by Sarah Shaffer, Dr. Susan Stover and colleagues at the J.D. Wheat Orthopedic Laboratory at the UC Davis School of Veterinary Medicine sought to characterize bone abnormalities that precede proximal sesamoid bone (PSB) fractures and determine if pre-existing abnormalities are associated with these fractures. The group retrospectively studied cases from California Thoroughbred racehorses that died from PSB fractures, and controls that died for other reasons.

The most common fatal injury in racehorses in the United States, PSB fractures account for 45-50 percent of such injuries in Thoroughbreds, and 37-40 percent in racing Quarter Horses. The PSBs are two comparatively small bones located in the fetlock that act as part of the suspensory apparatus. Fractures in these bones are likely due to the accumulation of repeated, stress-related processes. This is supported by evidence that racehorses in intensive training are at higher risk for PSB fractures, but the exact causes are not well understood.

Other repetitive overuse injuries in horses are known to be bilateral in nature, meaning that they are similar on both sides of the horse, with the more severely affected limb usually incurring the fracture. With this in mind, the study looked at both the fractured PSB and the intact PSB from the opposing limb of the same horse for all of the cases. The researchers hypothesized that horses with PSB fractures would also show evidence of stress in the PSB of the opposite limb and that the bone that sustained the break would show more severe changes than the intact bone.

The results showed that 90 percent of fractured PSBs from the cases had visible discoloration on the surface of the fracture, most commonly (70 percent of the time) in a characteristic crescent pattern. Directly below the cartilage, evidence of bone loss was noted in 70 percent of cases. This bone loss was located in the same region as the discolorations. Fractured PSBs had lower bone volume fraction and tissue mineral density within the lesion sites than comparable locations in opposing limbs and controls. These regions were contiguous with the fracture lines. Evidence of microdamage was also observed in fractured PSBs.

Overall, changes identified in the bones were more numerous in case horses than control horses and more severe in the fractured limbs than the opposing limbs in cases. Sampling from areas of bone distant from the lesions noted no significant differences in bones from case and control horses other than the presence of a lesion.

This data supports the role of microdamage and tissue remodeling in the formation of lesions in PSBs. It is important to note that all of the horses in this study were California racehorses, so it is currently unknown if the results will apply equally to racehorses in other areas. Future studies with larger sample sizes may provide further information.

Understanding the mechanism of PSB fracture is necessary in order to determine risk factors and prevent fractures. Combining this information with advanced technology, such as the recent introduction of positron emission tomography (PET scan) may facilitate identification of horses at risk for PSB fracture and inform management alterations to avoid injury.

* This work was supported with funding from the Grayson Jockey Club Research Foundation, Inc., the UC Davis Center for Equine Health, the Maury Hull Fellowship, and the Louis R. Rowan Fellowship.

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