Two Game-Changing Discoveries Suggest New Treatment For Horses Suffering From Uveitis

Globally, equine recurrent uveitis (ERU) is the most common cause of blindness in horses. The painful condition was not well understood until recently, but two new discoveries are providing hope for horses suffering from the disease.

Leptospira is often the bacterial infection behind ERU. Leptospirosis can be carried by small rodents that excrete leptospira in their urine, which can contaminate a horse's water and food. Standing water poses an increased risk of leptospira infection. Leptospires can survive in a horse's kidneys and eyes for extended periods. ERU is the result of a systemic infection; it can occur months to years after acute infection.

Drs. Bettina Wollanke, Hartmut Gerhards and Kerstin Ackermann reported that a chronic leptospiral infection in the eye cavity is only possible through biofilm formation. Biofilm is a thin, slimy film of bacteria that adheres to a surface.

Though antibiotics are often used in ERU treatment, biofilm bacteria are often resistant as the biofilm acts as a literal barrier to the infection. Additionally, the specific type of bacteria and antibiotic, as well as growth conditions, all play a role in how effective antibiotics can be.

This explains why ERU episodes are sporadic as well as why they can last for many years. It also explains why clinical signs may occur months or years after the systemic infection.

The trio concluded that ERU can be treated by the removal of the vitreous material that fills the middle part of the eye, where leptospirosis can reside undetected for years. The researchers note that it is important to determine that the horse is suffering from ERU and not another form of uveitis, in which case the removal of the material may not be helpful.

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The study team notes that if the eye does not improve that surgery may be needed.

More research is needed. Read more at HorseTalk.

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The Lowdown On Lipomas And Surgery Survival

Colic is a broad term that is often used to indicate any type of abdominal pain, but veterinarians can often determine — or at least narrow down — what is causing the abdominal issue. One common cause of colic, particularly in older equines, is a strangulating lipoma. 

A strangulating lipoma is a benign, fatty tumor on a stalk that can wrap around and strangulate a section of small intestine. There are no good markers to denote a horse that may be at risk of a lipoma other than advancing age. The only repair for this type of colic is surgery.

When the veterinarian has the horse on the table, he or she will prophylactically remove all of the lipomas found in the small intestine and small colon to prevent strangulation in the future. Older horses tend to be more stoic so may not show the intense pain they are in. For this reason, some strangulating lipomas are missed during vet exams. 

It's imperative that if a horse is suspected to have a strangulating lipoma that he is sent directly to an equine hospital equipped to handle surgery. The idea that older horses don't handle colic surgery and anesthesia well is a myth, according to EQUUS magazine. Older horses have as good of a chance of survival after colic surgery as younger horses. 

Read more at EQUUS magazine

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Can Surgical Removal Of A Mare’s Ovaries Fix Unwanted Behaviors?

A Danish study investigated if removing a mare's ovaries could offer relief from unexplained unwanted behavior. The changes in behavior were assessed by the owners of the horses. Some mares used in the study had ovarian cancer; others had no veterinary-diagnosed reason for their unwanted behavior.

Removing the ovaries was final attempt to resolve the unwanted behaviors as drug use to stop their reproductive cycles had failed and no issues with their reproductive tract could be found. Unwanted mare behavior can range from being uncooperative to aggression aimed at humans or other horses.

Drs. Daniel Taasti Melgaard, Martin Soendergaard Thoefner, Trine Stokbro Korsgaard, Morten Roenn Petersen and Hanne Gervi Pedersen, used the records of 28 mares that had their ovaries removed six to 24 months earlier and followed up with the horse owners, asking them to complete a questionnaire and respond to a telephone interview. Ten of the horses in the study had normal ovaries, 14 of the mares had ovarian cancer in one or both ovaries, and the other ovaries of the other horses were not examined for the presence of cancer.

Eight out of the ten mares (80 percent) with normal ovaries had improved rideability after their ovaries were removed; rideability improved in 57 percent (eight out of 14) in the mares with ovarian cancer. Mare behavior improved in about 40 percent of the cases studied.

The researchers conclude that mares without ovarian cancer may benefit as much from ovary removal as mares with ovarian cancer, showing improved rideability and behavior, though there is no obvious explanation as to why mares with normal ovaries benefited. The team noted that owner perception of improved behavior could be a placebo effect because they assumed the operation would work. They also stress that horses have a through diagnostic workup to rule out other issues before an ovariectomy is performed,

Read the full study here.

Read more at HorseTalk.

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