Study: Colic The Primary Cause Of Death For Geriatric Horses In Retirement Centers

The primary causes of death among horses at a retirement facility include colic, lameness, neurological deficits, and the cumulative effects of old age, according to new research from the Netherlands.

Using records from a private equine retirement center gathered over an eight-year period, researchers aimed to pinpoint the most common causes of death in aged horses and, more specifically, to determine the effects of pituitary pars intermedia dysfunction (PPID) on mortality.*

For this study, any horse 15 years of age or older was considered geriatric.

After an exhaustive review of records, researchers created fourteen categories for the cause of death: colic, lameness excluding laminitis, laminitis, down in the field, neurological deficit, sudden death, acute illness, chronic weight loss, tumor, fracture or trauma, behavior, financial, and old age. A “financial” cause of death indicated euthanasia occurred because of an owner's inability to pay for care, and “old age” designated a horse with multiple problems that cumulatively decreased welfare and whose life ended by planned euthanasia.

All horses at the facility were overseen by professional horsemen and veterinarians and were provided with routine care. Testing for PPID occurred if there were any clinical indications of the disease (cresty neck, history of laminitis, chronic infections, weight loss).

Of the 194 horses that resided at the facility, 80 geriatric horses died during the eight-year period. Twelve were between the ages of 15 and 19 years old, 25 were between 21 and 25 years old, 32 were between 25 and 30 years old, and 11 were 31 or older. The average age of those horses that died was 26 years old. All were euthanized or died of natural causes.

The most common cause of death among this population of geriatric horses was colic (20% of cases) followed by old age (15%) and lameness that did not involve laminitis (12%). Neurologic problems and an inability to rise after lying down rounded out the top five causes of death.

“For those of us that live and breathe horses, that spend time each day with horses, that study horses, these causes of death come as no surprise,” said Catherine Whitehouse, M.S., a nutritionist with Kentucky Equine Research. “The interesting aspect of this study is that this data was all mined from the records of horses housed at a single facility under similar management conditions. Because of this, there was less variation in care than there would have been if horses had been managed at multiple farms.”

With regard to PPID, of the 194 horses that resided at the facility, 125 (63%) were tested at least once for PPID. During the eight-year-study period, 62 horses of the 125 tested died, and 47 of those 62 (76%) had tested positive for PPID at an average age of 27 years old.

According to the study, horses were maintained on a diet of free-choice haylage with and were offered supplemental feed if necessary. The teeth of all horses were examined regularly and those with missing or problematic teeth were given mashes when necessary. Weight was monitored monthly using scales. “The horses at this facility appeared to be given top-flight care, especially when it came to provision of adequate feed, dental care, and regular deworming, all of which is important when it comes to lifespan,” Whitehouse said. “Old horses sometimes require more management, but the extra investment may pay off in added years at the end of a life.”

Aged horses often benefit from targeted supplementation. High-quality joint supplements can help ease the discomfort associated with the effects of a lifetime of service, and a research-proven hindgut buffer, like EquiShure, can help stabilize the pH of the hindgut so microbes can efficiently ferment forages.

*Van Proosdij, R., and S. Frietman. 2021. Retrospective analysis of cause-of-death at an equine retirement center in the Netherlands over an eight-year period. Journal of Equine Veterinary Science 110:103824.

Reprinted courtesy of Kentucky Equine Research. Visit ker.com for the latest in equine nutrition and management, and subscribe to Equinews to receive these articles directly.

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Are There Any Disadvantages To Popular PPID Treatment?

Pituitary Pars Intermedia Dysfunction (PPID or Cushing's disease) is a disease that affects many older horses, but it can often be controlled with the use of a medication called Pergolide.

In other parts of the world, Pergolide is used in human medicine to combat the symptoms of Parkinson's disease, restless leg syndrome, and hyperprolactinemia. Side effects can include fibrotic lesions of the atrioventricular valves in the heart.

Dr. Heidrun Gehlen, from the Department of Veterinary Medicine at the Free University of Berlin, gathered a team of scientists to determine whether the same effects would be seen in horses.

The scientists examined 23 horses between 19 and 30 years old, all of which had been diagnosed with PPID using the ACTH adrenocorticotrophin hormone test. The treatment group comprised 12 horses that had been receiving Pergolide for between 14 days and 6 years, while 11 other horses in the control group received no Pergolide.

The researchers performed an echocardiographic exam on all horses, and found that each was free of cardiovascular disease; no valve defects were found.

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Follow-up exams were then given to nine horses in the treatment group and five in the control group between three and eight months later. The findings were the same: use of Pergolide did not affect ventricular function or cause valve disease in horses.

Read more at Equine Science Update.

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Does Your Horse Have Cushing’s? Researchers Need To Hear From You

Scientists at the University of Kentucky's Gluck Equine Research Center and the University College Dublin have partnered to create a large-scale, 12-month study to determine if blue light can be used to help horses suffering from pituitary pars intermedia dysfunction (PPID or Cushing's Disease).

Dr. Barbara Anne Murphy, head of equine science at the School of Agriculture and Food Science at University College Dublin, and Dr. Amanda Adams of the Gluck Center are looking for horses to take part in the study to determine if exposure to blue light would minimize the development of the long, thick haircoat that is a hallmark of horses with PPID. Each participant will receive an Equilume light mask for their participation, whether their horse wears the mask or is a control horse.

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Owners or managers of horses with diagnosed PPID and that have a long, curly hair coat are invited to complete a short questionnaire by October 22 to see if they are eligible to participate. Medicated and unmedicated horses can apply.

The study will require monthly hair sample collection, as well as the completion of bi-monthly questionnaires and the provision of images.

Click here to complete the questionnaire

Read more at Equine Science Update.

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Elevated ACTH Could Signal Complicated Conception

A Japanese study using infertile mares has found that many have elevated levels of adrenocorticotropic hormone (ACTH). ACTH is linked to the endocrine disorder pituitary pars intermedia dysfunction (PPID).

Dr. Takeru Tsuchiya and a research team used 67 Thoroughbred broodmares with unknown fertility issues for the study. Each horse had a physical exam and was deemed healthy.

The mares were tested for PPID in the fall using baseline plasma ACTH concentrations; they were divided into three groups based on their ACTH concentration level: low, intermediate, and high.

The team found 77.3 percent conception rates in the low ACTH group, and 56.5 percent in the high ACTH group. The high ACTH group didn't have a significant difference in the number of breedings, but it had lower conception rates.

PPID affects 15 to 30 percent of horses over 15. High ACTH concentrations are common in older horses. Almost two-thirds of the mares used in the study had elevated ACTH hormones. ACTH may indirectly affect reproductive performance.

The study team concluded that if infertile mares are tested for ACTH concentration levels early, it may be possible to improve reproduction performance. They recommend that other factors, including other reproductive hormones, be investigated for their effect on reproductive performance.

Read the article here.

Read more at HorseTalk.

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