Are There Any Disadvantages To Popular PPID Treatment?

Pituitary Pars Intermedia Dysfunction (PPID or Cushing's disease) is a disease that affects many older horses, but it can often be controlled with the use of a medication called Pergolide.

In other parts of the world, Pergolide is used in human medicine to combat the symptoms of Parkinson's disease, restless leg syndrome, and hyperprolactinemia. Side effects can include fibrotic lesions of the atrioventricular valves in the heart.

Dr. Heidrun Gehlen, from the Department of Veterinary Medicine at the Free University of Berlin, gathered a team of scientists to determine whether the same effects would be seen in horses.

The scientists examined 23 horses between 19 and 30 years old, all of which had been diagnosed with PPID using the ACTH adrenocorticotrophin hormone test. The treatment group comprised 12 horses that had been receiving Pergolide for between 14 days and 6 years, while 11 other horses in the control group received no Pergolide.

The researchers performed an echocardiographic exam on all horses, and found that each was free of cardiovascular disease; no valve defects were found.

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Follow-up exams were then given to nine horses in the treatment group and five in the control group between three and eight months later. The findings were the same: use of Pergolide did not affect ventricular function or cause valve disease in horses.

Read more at Equine Science Update.

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Pony Mistakenly Overdosed On Pergolide Has No Lasting Effects

A pony in Germany was accidentally given 110 times the veterinary recommended dose of pergolide (sold under the name Prascend). The most prescribed medication for horses that suffer from pituitary pars intermedia dysfunction (called PPID or Cushing's disease), pergolide mimics dopamine's action in the body.

Instead of being given half of a 1-milligram tablet (.5 milligrams), the pony was given 55 tablets. The mistake was discovered four hours after the pony had been medicated. The veterinary exam showed that the horse had an increased heart rate, but no other symptoms.

To try to prevent any additional absorption of the medication, vets gave the pony paraffin oil and activated charcoal through a nasogastric tube. They also administered two drugs: One to prevent heart arrhythmias, which is a known side effect of pergolide overdose in humans, and one to counter pergolide's dopamine-biding action.

The pony was unusually anxious for the week after his overdose, reacting to bright lights and fast movement. He also had a decreased appetite. Within eight days of his overdose, the pony was back to normal.

Researchers concluded that the pergolide overdose resulted in only minor, temporary effects.

Read more at EQUUS magazine.

The post Pony Mistakenly Overdosed On Pergolide Has No Lasting Effects appeared first on Horse Racing News | Paulick Report.

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