Penn Vet Develops New Gene Doping Test

A new test developed by researchers at the University of Pennsylvania School of Veterinary Medicine (Penn Vet) can detect the presence of gene doping in equines. Partly supported by the Pennsylvania Horse Breeders Association (PHBA) and the Pennsylvania State Horse Racing Commission, the findings, which systemically detect the local administration of illicit, gene doping therapies, are a significant breakthrough. Unlike other small molecule pharmaceuticals, gene doping agents trigger cells to produce performance-enhancing proteins, which often are virtually indistinguishable from naturally occurring proteins within the body, making it more difficult to determine whether or not an animal has had gene therapy.

The team of Penn Vet researchers has created and validated a quantitative real-time polymerase chain reaction (PCR) test–a term that has become common vernacular due to COVID-19 tests-which is able to detect the presence of a gene doping agent in plasma and synovial fluid after its intra-articular administration in horses.

“For the first time, we have demonstrated that a PCR test performed on a blood sample can detect the local administration of a gene therapy into the joint of a horse,” said Mary Robinson, PhD, VMD, DACVCP, assistant professor of Veterinary Pharmacology and director of the Equine Pharmacology Laboratory at Penn Vet's New Bolton Center. “While this test is currently limited in that it can only detect a specific gene therapy, it provides proof of concept that a gene therapy administered into the joint can be detected in a blood sample in a manner that is quick, convenient, and consistent with our long-term goal of deploying pre-race testing someday in the future.”

The researchers at Penn Vet were able to detect the gene doping agent in equine joint fluid after it was administered intra-articularly and in blood for up to 28 days, making it useful for both pre-race and out-of-competition testing.

More work is being done by Penn Vet with the goal of someday creating “biological passports” and screening tests that would successfully identify multiple gene doping agents for even longer periods of time. Researchers believe biomarkers could also be key in detecting gene doping as well as predicting injuries before they happen.

“We still have a lot of work to do to better understand the nature of biomarkers and how to fully harness their capabilities, but the science for detecting gene doping is getting there and much more quickly than any of us could have anticipated when we started this research,” said Robinson. “Ideas that once may have seemed unattainable–like a hand-held, stall-side testing device–are now coming into sight as real and tangible possibilities. We just need continued support to help get us there.”

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Mattress Mack: ‘Threats Of Fraud Are Real, Whether The Fraud Is Real Or Not’

Asked what he would like to change about the horse racing industry, Thoroughbred owner James “Mattress Mack” McIngvale told Thoroughbred Racing Commentary that he'd like to see a sport with zero tolerance for performance-enhancing drugs.

“Threats of fraud are real, whether the fraud is real or not, just like this last presidential election,” McIngvale told TRC. “Half the population doesn't believe in the results. So, horse racing can't be in that same boat. Cannot go there. It's no fun when you've got no shot from the get-go.”

McIngvale pointed to the newly-signed federal Horseracing Integrity and Safety Act as a step in the right direction.

“[HISA], it's very good, just has to be enforced,” he said. “People need to run these horses on hay, oats and water, just like we ran Runhappy. It makes the horses happier. It makes the betting more transparent. And the fans don't think they're an outsider looking in.”

Read more at the Thoroughbred Racing Commentary.

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Feds: More Doping Charges Could Be in Pipeline

The federal prosecutor leading the case against an alleged network of racehorse dopers underscored several times during a Nov. 17 court hearing that the government might not yet be done bringing new charges that could involve either existing or fresh defendants as it continues to investigate a purported years-long conspiracy to manufacture, mislabel, rebrand, distribute and administer performance-enhancing drugs (PEDs) to Thoroughbreds and Standardbreds across America and in international races.

“There may well be other crimes as to the particular defendants in this case,” United States Attorney Andrew Adams said in response to a direct question on that topic from U.S. District Judge Mary Kay Vyskocil. “And [the government] is continuing to look at other people who are not currently charged.”

During the Tuesday morning teleconference, 14 defendants pleaded “not guilty” to updated charges in US. District Court (Southern District of New York) stemming from a Nov. 5 superseding indictment that replaced an original indictment filed after a wave of arrests in March.

The headline Thoroughbred industry defendants in the case are the now-barred but formerly above-norm-win-percentage trainers Jason Servis and Jorge Navarro.

A dozen other alleged co-conspirators either appeared via phone or had pleas entered by their attorneys on Tuesday. They include drug manufacturers, distributors, stable employees, and veterinarians allegedly involved to various degrees in the five counts listed in the indictment. They are: Erica Garcia, Christopher Oakes, Michael Tannuzzo, Marcos Zulueta, Rebecca Linke, Kristian Rhein, Michael Kegley, Jr., Alexander Chan, Seth Fishman, Jordan Fishman, Lisa Giannelli, and Rick Dane, Jr.

In addition, five individuals named in the original March indictment were not included in the superseding indictment, which has led to speculation that they could be cooperating with law enforcement authorities to widen the case in exchange for having charges dropped. Two other defendants pleaded guilty in September.

On Tuesday Adams revealed that prosecutors now believe that at least two of the alleged conspirators–Chan and Rhein–were pushing some fake PEDs to Servis that didn’t really enhance performance. But, the prosecutor added, the government will be treating those substances as if they were actual PEDs because Servis’s true intent was to allegedly dope horses.

Adams explained that the recently added wire fraud charges alleged against those three defendants were brought to light by investigators who uncovered “a false billing scheme relating to certain drugs being administered by Dr. Rhein’s veterinary practice, including to horses under the care and training of Mr. Servis.” He added that it amounts to false billing when “certain drugs were promoted or intended to be used as performance-enhancing drugs, regardless of the efficacy of those drugs.”

The prosecutor then elaborated: “That is, a drug that is promoted and intended to be a performance-enhancer but is, you know, a dud, is nevertheless [considered to be] a misbranded an adulterated drug for the purposes of this indictment…”

And because those allegedly false billing transactions purportedly were conducted via some form of phone, text, or email communications, they constitute wire fraud, the government is alleging.

When Judge Vyskocil asked Adams point-blank to name the victims who were allegedly defrauded via the five counts in the indictment, Adams did not hesitate to answer.

“Horse owners are among the primary or intended victims,” with regard to the wire fraud charges, Adams said.

“With respect to misbranding, the racetracks, racing commissions, owners [and other] competitors are all among people who were in the minds of the defendants charged with the misleading and deceit,” Adams added.

The news that more charges and/or yet another expanded time frame for the alleged crimes could be in the pipeline was not welcomed by defense attorneys, who have already lodged concerns about the massive volume of electronic evidence being introduced in the case and how an elongated discovery and pre-trial period is not in the best interest of their clients’ right to a speedy trial.

“We do continue to investigate and continue to look into all aspects of the case,” Adams said when pressed by the judge for some sort of timeline on potential future charges. “The wire fraud that has come down now is largely the fruit of investigations that straddled the original indictments. It was built on information from both before and after. And I don’t leave aside the possibility that that may happen again, with respect to other false billing practices.”

Servis’s attorney, Rita Glavin, said she wanted a more definitive answer so she could make the best defense possible for her client without having to start all over if new charges got levied against him. She asked Adams, “Does the government, as we sit here today, think it’s likely that there will be a superseding indictment in the next four to five months?”

Adams replied, “The government is not under an obligation to answer that question. And it frankly will not impact, in the government’s view, any timelines set for Mr. Servis.”

Glavin countered: “Today is the first that I’ve heard from the government a whisper that there may be another superseding indictment. And I understand the government’s representation that they don’t believe it would impact Mr. Servis. But I would have to see that when I see it. I don’t know what their current investigations are. But I certainly would be concerned about setting a schedule in the case if we’re going to see new charges come out.”

Despite the open-ended nature of the ongoing investigation and the mounting reams of evidence it is generating, Vyskocil declined to set a deadline for discovery. The judge did, however, aim to set a timetable for future proceedings that allowed the defense proper time to sift through all the relevant materials during the discovery period and to potentially file motions based on what attorneys uncover.

So a Feb. 5 date has now been set for the first round of what the judge termed as “dispositive motions” that the defense could file to put an end to some or all of the charges against defendants. The prosecution would then have a month to reply (Mar. 5), and the defense would get three additional weeks to counter those replies (Mar. 26).

A second round of motions dealing only with defense requests to suppress evidence or expert testimony now has a May 24 target deadline, but a status hearing scheduled 10 days before then will determine if that is a realistic date.

Vyskocil said at this point, it would be “premature” to even consider a pre-trial schedule that extends beyond the time frame of next spring.

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Irwin: With Horseracing Integrity And Safety Authority, Will The Culture Change?

Sixteen years after I first suggested in an Op/Ed in The Blood-Horse that the United States Anti-Doping Agency (USADA) should be hired to oversee drugs in American racing and eight years after like-minded horse folks founded the grass roots organization named the Water Hay Oats Alliance (whose mission statement mirrored my original suggestion), the sport of horse racing in the United States is on the verge of seeing this goal at long last come to fruition with Monday's announcement that Senate Majority Leader Mitch McConnell will push for the creation of the Horseracing Integrity and Safety Authority.

USADA supremo Travis Tygart will not be beaten in his attempt to rein in cheaters, just as the current investigations that have led to the initial arrests of accused trainers Jorge Navarro and Jason Servis have shown what can be accomplished when real G-men go after rule breakers.

To me it is a given that systems, protocols and policing practices will be put in place by USADA and dedicated investigators will be hired to put a stop to cheating with the illegal designer drugs that have turned hitherto unknown horsemen into trainers with Hall of Fame credentials.

As far as I am concerned, the hard work that is to come is finally in the hands of those who can be trusted to make this happen.

We are now ready to focus on the next elephant in the room: the culture of the North American backstretch community, which includes those trainers, owners, veterinarians and other assorted enablers and misfits that do not want to follow the rules.

I look at the past decade as a time in racing that is reminiscent of the Black Sox Scandal in baseball. While our scandal in some regards is still unfolding as the investigations continue for the next year or so, it is time for all of us to take a strong look at the culture that made it happen, because unless this culture can change, racing cannot hope to turn the page and seek recognition as a clean sport.

Cheating by trainers, vets and owners with illegal and unknown Performance Enhancing Drugs has until very recently gone largely unchecked because those agencies charged with regulating the sport have shown no interest in addressing the problem.

Horsemen's organizations, State regulators, racetrack operators, racing boards and the media with few exceptions have not done their job of creating a positive culture. Trainers bent on cheating come up with any number of reasons that are as lame as the unsoundest horse in the barn to be able to keep their candy. State regulators will not rock the boat for fear of losing their jobs. Racetrack owners have been operating under the false notion that exposing cheaters will hurt their business. Racing boards are peopled by political appointees that want to defer rather than regulate. The media has enough clued-in writers and analysts to make a difference, but instead of being real they have made a light industry of glorifying trainers that cheat because that is what is expected of them.

OK, so now that a rejuvenating breath of fresh air is about to be ushered into the sport thanks to installing USADA to oversee drugs in racing and the horsemen's pleas to retain all of their drugs has been silenced, will those movers and shakers in racing agree to play the game on the level?

I am extremely worried the answer may be “no” given the history of the sport and the unbridled energy of the worst aspects of human nature. I do believe that plenty of horsemen and owners seek an edge only because they think everybody who is winning does the same thing. I think these people can and will adapt to a more normal way of doing business. I know plenty of them really appreciate the change.

The ones I fear are those horsemen that have seen the awesome power of illegal drugs and no matter what happens will always seek an edge because they have been emasculated by the power of drugs and think their skills will never be good enough to allow them to win on the square.

While most horsemen outwardly behave as though they have confidence in themselves, the truth is that very few of them really do and they live in mortal fear of being found out as a fraud.

I reckon that many of these will fall by the wayside, because if they are forced to stop cheating, their stats will reflect the new normal and fewer owners will supply them with horses. Others who are smarter than the average fellow will continue to cheat and, for a time, may continue to get away with it. But eventually the axe will fall not only them but their enablers—the owners who supply them with drugs, the money to buy drugs and expensive horses.

My hope for racing—and it is just that, a hope—is that those individuals who have enjoyed phenomenal success because of their cheating and only play a game they can dominate if they can cheat—will fade from view and go back to other money games on Wall Street or the corporate jungle and return to swindling their peers, while leaving the rest of us cases of arrested development to conduct our silly contests of equine speed.

Once the landscape has been cleared, racing in my fantasy world would take place on a level playing field for the first time in an entire human generation and those folks who really like the horses will produce a product that can be embraced by all of those horseplayers, fans, owners and trainers who love the greatest game played outdoors.

It could happen.

Barry Irwin is the founder and CEO of Team Valor International.

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