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Wry nose in horses does more than just look odd — it can affect the way a foal breathes and may lead to weaning and performance issues. It's unknown if the defect, where the upper jaw and nose are shifted to one side, is genetic or caused by an issue in utero.

Dr. Cassandra Sapper and colleagues at the University of Zurich tried a new, surgical approach to correcting the issue on two foals: the team cut the incisive and maxillary bones, then inserted a locking compression plate with screws to stabilize the gap. The front part of the septum was resected and a plate used to fixate the nasal bone deviation.

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After surgery, the team reported that the foals' respiratory issues and facial malformation were markedly reduced, though the underbite and deviation could not be completely eliminated. The new technique did not cut the skin and muscle on the side of the head, so there was less soft tissue trauma than with traditional means of correcting wry nose.

Though previously it had been suggested that wry nose corrective surgery be done at two to three months of age, the study team used foals that were three and seven and a half weeks old. This was deemed advantageous because of their ability to heal rapidly at a younger age. The study team concluded that wry nose corrective surgery can be accomplished using this new method in young foals.

Read the case report here.

Read more at HorseTalk.

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Boehringer Ingelheim today announced the U.S. launch of the Aservo EquiHaler (ciclesonide inhalation spray), the first FDA-approved inhalant therapy for horses with severe equine asthma.

Developed after a decade of collaboration between Boehringer Ingelheim's human pharmaceutical and animal health businesses, the Aservo EquiHaler offers the promise of relief to thousands of horses that suffer from severe equine asthma, which affects 11 to 17 percent of horses.

Horses with severe equine asthma typically have clinical signs that include difficulty breathing, coughing and nasal discharge, which can have a significant impact on a horse's performance and quality of life. Over time, severely asthmatic horses may develop changes in the lung, which makes it difficult to breathe, even at rest.

“We understand the unique and inextricable link between animals and people. By delivering value through innovation, we strive to enhance the wellbeing of both and help shape the future direction of the industry,” said Caroline Belmont, Head of US Global Innovation and US Regulatory Affairs at Boehringer Ingelheim Animal Health. “We are focused on developing breakthrough therapeutics, like the Aservo EquiHaler, for animal disease areas with unmet needs to make a true impact in the lives of horses and their owners.”

The Aservo EquiHaler marks an industry first in equine medicine, as until now, there has been no FDA-approved inhalant therapy for use in horses with severe equine asthma. Severe equine asthma is an inflammatory disease of the lower airways caused by breathing in high concentrations of organic dust particles small enough to pass with air to the lower airways. Such particles are commonly found in hay and bedding.

Boehringer Ingelheim Animal Health used the Respimat inhaler, developed by the company's human pharmaceutical business, as a basis to develop the unique Soft Mist Technology of the Aservo EquiHaler, which is designed specifically for use in horses. The Aservo EquiHaler includes an ergonomic handle and dosing lever for ease of user handling, and a nostril adapter that fits inside the nostril of the horse, allowing them to easily inhale the medicated mist into their lungs.

The active ingredient in the Aservo EquiHaler (ciclesonide inhalation spray) is ciclesonide, a glucocorticoid (steroid) that becomes activated in the lungs, which allows for the targeted delivery and activation of the medication. Studies in horses with severe asthma have demonstrated that administration of ciclesonide reversed airway obstruction associated with severe asthma, and to date, ciclesonide is the only glucocorticoid not associated with suppression of serum cortisol, a desired treatment outcome.

To learn more about Aservo EquiHaler, click here.

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