Diodoro Resurfaces At Lone Star Park

High-profile trainer Robertino Diodoro, who is serving a provisional suspension from the Horseracing Integrity and Welfare Unit (HIWU) after the banned substance levothyroxine was found in his barn at Oaklawn Park, has entered a horse for the April 18 card at Lone Star Park. On opening night, he has entered Master of Disguise (Mastery) in a maiden special weight race with a purse of $33,000.

Diodoro is eligible to race in Texas because the Horseracing Integrity and Safety Authority (HISA) does not have jurisdiction in that state.

Diodoro did not return a phone call from the TDN, but it appears that he will be busy at the Lone Star meet, which concludes on July 14. Diodoro has been allotted 50 stalls, which appears to be the maximum amount allowed by the track's racing department. He has not started a horse since April 3 at Turf Paradise. He was able to run in Arizona after his suspension was announced because the horses had been entered before Diodoro was notified of the violation

Diodoro was provisionally suspended by HIWU on March 29. Though he has been summarily suspended the case must still be reviewed by HIWU's Internal Adjunction Panel. Diodoro also has the option of trying to contest the suspension in court.

Levothyroxine is a thyroid medication. According to the National Library of Medicine the use of thyroid hormones for doping to enhance performance in human sports has long been controversial. There have been claims of abuse of these drugs, but they have not been prohibited by the World Anti-Doping Agency.

The Texas Racing Commission interpreted its state racing rules and concluded that only the racing commission can legally oversee racing in the state and therefore would not allow HISA to come into Texas. Because they are not under HISA's jurisdiction, Lone Star Park and Sam Houston cannot send their simulcast signal out of state.

Diodoro was the leading trainer in 2023 at Oaklawn Park and is currently still in second place in this year's Oaklawn standings. Training since 1995, Diodoro has 3,184 career wins and a winning rate of 21 percent.

A similar scenario is playing out in Louisiana, where trainer Jonathan Wong has begun racing. Wong received a two-year suspension from HIWU after he had a horse test positive for Metformin, a drug that is commonly used by humans to combat type 2 diabetes. Like Texas, Louisiana racing is not under HISA's control. Wong has started eight horses in Louisiana with no winners. He has four horses entered at Evangeline Downs next week and another Saturday night.

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Weaver Trained Horse Tests Positive for Metformin

According to the Horseracing Integrity and Welfare Unit (HIWU) a horse trained by New York-based conditioner George Weaver has tested positive for the banned substance metformin. Weaver has asked for a test on a split sample and will be allowed to continue to train pending the results of that test.

The horse in question is Anna's Wish (Dailed In) and the alleged violation occurred after she was tested following the March 16 Cicada S. at Aqueduct in which she finished third.  Metformin is listed as a banned substance by HIWU, which means Weaver faces a possible suspension of up to two years. The “banned” category is the most serious class of drug offences under Horseracing Integrity and Safety Act (HISA) rules.

Metformin is a drug used to treat diabetes in people. With more than 20 million patients taking it, metformin ranks as the nation's third-most-prescribed human medicine, according to the consumer healthcare website Healthgrades.

Weaver joins Mike Lauer, Jonathan Wong and four other trainers who have had horses test positive for metformin. The metformin positives have been controversial because of the number of people who take it for diabetes, which raises the possibility of environmental contamination.

“This is a clear case of external contamination,” said Weaver's attorney, Drew Mollica. “The facts will show that Mr. Weaver had no hand in this and bears no fault for the alleged violation. We will seek a split sample and once those results are in we believe we will be able to offer clear and convincing evidence that Mr. Weaver bears no fault. At some point, HISA slash HIWU must accept the fact that these universally prescribed medications exist in the environment. The attempt to destroy a man's career predicated on a prevalent substance and in a case where he bears no fault should not only shock the conscience, but it should also shock the entire racing community.”

According to Mollica, Anna's Wish's groom takes metformin.

“The groom who cares for the horse is on the medication,” he said. “This is a clear case of contamination. The consequences that HIWU seeks to impose are career killers with no basis in reality.”

A former assistant to Todd Pletcher, Weaver has been on his own since 2002. According to The Jockey Club's online rulings database, Weaver has had just two prior positives, one for acepromazine and the other for promazine sulfoxide. In both instances, he was not suspended but was fined $300.

For his career, Weaver has had 6,467 starters and has won 983 races. His career earnings are $50,753,128.

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Letter to the Editor: Detection of Banned Drugs in Horses

As a Clinical Pharmacologist (human) and an avid horse player, I have grown tired of these instances of biologic samples from horses having banned substances found and the “interesting” explanations as to how the exposure happened. One recent example was a story of a horse in which three samples of blood had metformin (a drug used to treat type II diabetes in humans) detected. The explanation was that a groom and later the trainer was taking metformin and “touched the horse's face.”

This explanation is questionable from a clinical pharmacology standpoint. Metformin for human use is a film coated tablet (coated with a polymer). Unless the individual taking the tablet crushes or chews it (and puts a finger in the mouth), handling the film coated tablet does not transfer metformin to the hands. Additionally, published data shows that the amount of metformin absorbed from an oral dose in a horse ranges from 3.9-7.1% (fed vs fasted state) which is minuscule. Finally, the suggested dose of metformin in horses for approved use is 15 mg/kg (7.5 grams in a 500 kg horse) versus a usual 500 mg dose in a human. Thus, horse exposure from a human dose (by rubbing the face) or even putting a finger/hand in the horse's mouth would be quite a stretch of science.

This story is not the only one that TDN readers have seen over time. We have been subjected to stories of a horse with detectable betamethasone in his blood supposedly not from an intraarticular injection but due to use of a topical product, a horse with dextromethorphan in the blood due to a groom using a cough syrup and urinating in the stall and many other stories. These explanations stretch the science of clinical pharmacology to unreasonable levels.

I'd like to offer my human-based clinical pharmacology expertise to HISA/HIWU to “solve” these human-based inaccurate explanations in terms of horse exposures to banned drugs, gratis.

Horse racing is a great sport with a long tradition. Unfortunately, stories of horses having banned substances (no matter how low the exposure) is a negative for a sport where interest at least in the USA is declining and groups like PETA show up to protest at large racing venues putting more negative attention to the sport. But, worst of all, use of banned substances is bad for the horses and aren't the horses our primary interest/concern?

Sincerely,
Joseph S. Bertino Jr., PharmD, FCP, FCCP
Guilderland, New York

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Wong Suspended Two Years and Fined $25,000, Says He’ll Appeal

Trainer Jonathan Wong has been suspended for two years and fined $25,000 for a post-race metformin positive from last June after a Jan. 9 hearing before the Horseracing Integrity and Safety Authority's arbitration panel.

The two-year period of ineligibility retroactively starts July 1, 2023, when Wong's initial provisional suspension was first imposed.

He will also pay $8,000 of HIWU's share of the arbitration, in addition to his own arbitration fees.

As the maximum possible sentence for such a violation, the ruling marks the latest twist in a case that became entangled in the evolving rules of the Horseracing Integrity and Safety Act's (HISA) enforcement efforts. While the arbitrator rejected that this was contamination, several other Metformin cases have called into question whether or not possible environmental contamination should be treated the same way that other positives are treated.

The case also appears far from over. In a short statement, Wong wrote that he had appealed the ruling which could now go before the Federal Trade Commission, head to federal court, or both. Wong also explained that he would seek a temporary injunction against the ban.

“By the time this new story breaks, we will have already filed or will be filing our appropriate appeal, whether in Federal Court or with an Administrative Law Judge through the Federal Trade Commission. It is entirely possible we will dual-path this situation and file in both. In all instances, we will seek an Emergency Order with Injunctive Relief.  The facts and merits of the case will be heard,” Wong wrote, in a joint statement with his long-time owner, Brent Malmstrom.

Wong-trainee Heaven and Earth (Gormley) broke her maiden at Indiana Grand June 1 but subsequently tested positive for the prescription drug Metformin, a type 2 diabetes treatment that HISA has classified as a banned substance.

As a matter of protocol at that time, HIWU initially provisionally suspended Wong at the beginning of June when the A sample returned a positive finding for Metformin.

The HISA Authority subsequently announced that it had modified the rules surrounding provisional suspensions. Under the revised provisions, responsible parties who request B Sample confirmation following a positive test for a banned substance would no longer face a provisional suspension until the B sample findings are returned.

In Wong's case, he was notified on Aug. 9 that the B Sample confirmed the Metformin positive.

Though Wong was technically permitted to return to training for a brief period while the B sample was being processed, he explained at the time that his owners did not wish to transfer the horses back with the B Sample results expected imminently, and effectively has not trained since July 2.

Metformin ranks as the nation's third-most-prescribed human medicine, according to the consumer healthcare website Healthgrades, with more 20 million patients taking it. As a banned substance under HISA, a metformin positive comes with a possible two-year suspension and $25,000 fine.

Because of the possible severity of the sanctions and its ubiquity in the environment, metformin has been at the heart of several cases since HISA's anti-doping and medication control program went into effect that have led some to question whether HIWU is deploying too strict an enforcement approach to the drug.

In justification of its stance, HISA CEO Lisa Lazarus told the TDN last month that “we do have intelligence that metformin is being used intentionally to enhance performance.”

Furthermore, in October HIWU announced that internal reviews of its six contracted laboratories uncovered different limits of detection in blood for metformin, triggering a process of testing harmonization in blood across the labs for the drug. Until that point, all the metformin positives originated from just the one lab.

The Horseracing Integrity and Welfare Unit (HIWU) has posted a detailed explainer of the ruling on its website.

The report details how the A sample was sent to the HIWU-accredited Industrial Laboratories in Denver Colorado, while the B sample was sent to the Chicago Analytical Forensic Testing Laboratory in Chicago, Illinois, for confirmatory analysis.

According to the report, the Kenneth L. Maddy Equine Analytical Chemistry Laboratory at the University of California, Davis, conducted “Further Analysis” on the A blood sample “received from Industrial,” and on the “remainder of the B urine sample” received from the Chicago lab.

“Apparently, they can swing till they're happy,” said Malmstrom, when asked about that development.

Wong's legal team presented several defenses during the hearing, including that Heaven and Earth had a groom who urinated in the stall and frequently touched the horse on the mouth. They said that the groom was on Metformin, and had fled to Mexico after the finding, for fear he had contaminated the horse, and could not be found. He argued that the sample being sent to the Maddy lab for further testing—a third laboratory–suggested questionable conduct on the part of HIWU. The samples at all three labs were positive.

“There is, unfortunately, the simple fact that Mr. Wong has been untruthful in this proceeding. I find that Mr. Wong has not met his threshold burden of establishing the source of the contamination and thus there is no mitigation that might possibly be considered for Wong, and his sanction should be two years of Ineligibility,” wrote arbitrator Nancy Holtz in her finding.

“There is no doubt that Mr. Wong is an experienced, highly successful trainer who has climbed the ranks of this industry from the bottom up. His conduct and performance as a trainer presents a mixed bag: He has submitted numerous letters of support and praise from a constellation of highly regarded people in the horse racing industry. There is also no doubt that Mr. Wong has suffered financially, professionally, and emotionally from the Provisional Suspension and this will no doubt continue during the balance of the Ineligibility period. Balanced against these facts, however, is a record which does not support that Mr. Wong did much to prevent this contamination from occurring. If Mr. Wong was engaged in routine, frequent trainings of his staff regarding not urinating in the stalls, keeping hands clean and so on–which I do not believe–he certainly did not couple this with any level of monitoring, enforcement, or deterrence such as through imposing consequences for violators. Mr. Wong is no doubt a decent person who, in his own way, has tried to put the safety and welfare of his horses first. But despite his best intentions, the evidence is clear that Mr. Wong has abdicated his obligation as a Covered Person to protect the safety and welfare of the horses under his care consistent with ADMC Rules.”

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