laminitis | Horse Racing Free Tips

Endocrine Issues: Designing A Diet For A Metabolic Mare

Question: My 17-year-old Morgan mare weighs about 1,200 pounds and is in moderately fleshy body condition, just right by my estimation. I ride purely for pleasure, usually at the walk and trot. On days I don't ride, I longe her. She's fed 13 to18 pounds of soaked hay daily, 3 pounds of unmolassed straw/alfalfa chaff, a vitamin and mineral supplement, and biotin. She maintains her weight on this. Her hooves are strong, but her coat does not shine as it should. She has equine metabolic syndrome (EMS) with bouts of mild laminitis. This year she was extremely sensitive to the grass and has spent long stretches in her stall following a laminitic episode that was more severe than usual. Despite these laminitis flares, she has no radiographic changes to her coffin bones. She's added something new to her list of ailments lately, though: occasional mild colic. What else can I do for her from a nutritional perspective?

Kentucky Equine Research responds: A diagnosis of EMS with laminitic episodes can make diet formulation a challenge, though you seem to be on the right track. Her basic ration, which consists only of forages and vitamin and mineral fortification, is appropriate given her body condition. You are wise to offset the potential soluble carbohydrate content of her hay by soaking it prior to every meal.

In reference to future grazing, however, continue to proceed cautiously and under the direction of a veterinarian that is familiar with the mare's endocrine-related problems. She has shown that she is becoming more and more sensitive to pasture grasses, so her time spent grazing might be restricted, even severely so, in the future. Some horses with metabolic disorders cannot handle grazing at all, regardless of season, time of day, or pasture composition. For these horses, a drylot that allows them to exercise as they wish with suitable preserved forage at their disposal is an option. With respect to pasture and hay, try to keep the level of nonstructural carbohydrates below 12 percent.

Two high-quality supplements from Kentucky Equine Research might also help, especially if you believe she may be able to tolerate some grazing in the future, even if it's limited by a grazing muzzle of another means of restriction. EquiShure is a time-released hindgut buffer that supports digestive health by minimizing disruptions in the microbial population brought about by diet or management changes, including those prompted by grazing. EquiShure stabilizes the pH of the hindgut and reduces the incidence of recurrent colic in some horses.

Another research-proven product recommended to reduce inflammation and support a normal endocrine response is EO-3, a marine-derived supplement that provides the specific omega-3 fatty acids DHA and EPA, which are known to have many health benefits. Further, EO-3 will likely add shine to her coat and may keep certain skin problems, such as scratches, from developing.

Equine Obesity Connected To Increased Chance For Laminitis

Obesity in domesticated horses is a growing problem, Dr. Shannon Pratt-Phillips, and equine nutritionist at North Carolina State University, told the American Farriers Journal last week. One primary concern is that obesity can increase a horse's chance of developing laminitis, the potentially deadly inflammation of sensitive layers of tissue (laminae) inside the hoof.

Pratt-Phillips explains that fatty tissue is an inflammatory organ, which produces compounds that lead to inflammation in multiple different parts of the body. Those compounds can negatively affect the vasculature within the laminae, increasing the possibility for laminitis.

In addition, excess weight can have a negative effect on the horse's overall hoof health.

“Proper blood circulation is partly attributed to the compression and expansion of the digital cushion within the hoof,” Pratt-Phillips writes. “If a horse is carrying excess weight, the digital cushion's function may be compromised, resulting in poor blood circulation and laminitis.”

Of course, more weight can also cause strain on the hoof wall as it expands to absorb the concussion of a horse's movement.

“Over time, obesity may disrupt the integrity of the hoof wall, resulting in cracking or crumbling hooves,” wrote Pratt-Phillips.

Read more at the American Farriers Journal.

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Breakthrough Laminitis Research Opens Potential New Avenues For Treatment

Horse owners usually dread hearing the diagnosis of “Laminitis.” The disease plagues horses of many backgrounds, ages and disciplines. Using genetics, UF/IFAS and University of Pennsylvania School of Veterinary Medicine scientists have made a breakthrough in the disease thanks to funding from The Foundation for the Horse.

A horse's hoof has a tough job. It must support a heavy animal which can move faster than 40 mph. Laminitis occurs when inflammation and damage of the tissue takes place between the hoof and coffin bone. It causes lameness, a diminished quality of life and often results in euthanasia.

“Laminitis is a tough problem for the horse and its owner,” said Dr. Samantha Brooks, UF/IFAS associate professor of equine physiology. “We have very few tools in our arsenal to manage the disease itself. We treat symptoms, pain and mechanical instability but do not have anything to target the cause just yet.”

Laminitis studies have previously been hindered by the scarcity of genetic information specific to hoof tissues. Scientists tapped into the University of Pennsylvania's New Bolton Center Laminitis Discovery Database, an archive of data and sample sets from naturally occurring laminitis cases collected since 2008. Using that database, researchers examined 36 archived tissues of 20 Thoroughbred horses treated for laminitis.

There are three types of laminitis, and all impair the structure and function of the horse's foot. This research provided a snapshot of the active pathways and functions of the hoof, with a focus on supporting limb laminitis – the laminitis to which famous racehorse Barbaro succumbed.

“We understand the situations that trigger an episode of laminitis, but we do not have a good understanding of what is happening in the hoof,” said Brooks. “This study took a very comprehensive view of the processes early in the development of laminitis.”

Using gene expression analysis, researchers catalogued the changes in gene transcription across the 20 horses. Some had healthy feet, some were early in the disease process and others were more severe. Researchers identified trends in the disease process.

“By tapping into my lab's database and incorporating Dr. Brooks' unparalleled expertise in equine genetics and transcriptome analysis, we have identified new and promising pathways in cell stress and inflammatory response that significantly enhance our understanding of supporting limb laminitis and its disease processes,” said Hannah Galantino-Homer, VMD, PhD, DACT, senior investigator in Laminitis Research at Penn Vet's New Bolton Center.

The research resulted in three key findings.

The first related to keratin, an important structural protein that helps maintain the structural integrity of materials like hair, nails and horse hooves. This study was one of the first to examine the changes in the keratin family through the laminitis disease process. Some of the keratin-related genes and regulation of the cell's manufacturing process started to diminish as the disease began. This could be compared to when a car gets a flat tire; it may still be running but it loses appropriate function and slows down.

Another type of cell machinery often studied in laminitis are a class of enzymes called metalloproteinases; enzymes that help maintain the cytoskeleton. These enzymes must maintain a careful balance. Hooves must be able to grow and not break down under the weight of the horse, which requires a balance of remodeling and building tissues within the hoof. When the metalloproteinases become too active, the hoof begins to lose structural strength. One previous theory for treating this process was to stop these enzymes from becoming too active. But treatment targeted these enzymes might also stop hoof growth, which would likely lead to further issues.

When keratin degrades, inflammation in the hoof leads to laminitis. Scientists found a collection of genes responsible for triggering that inflammation which could pave the way for future medications to treat the inflammation. The genes led researchers to believe that some human inflammatory medications for autoimmune disorders may help horses with laminitis.

Changes in gene expression in diseased tissue are often reflected in changes in the proteins that can be detected in the blood as the disease progresses. For example, specific proteins, or biomarkers, that increase in the blood in humans following traumatic brain injury had increased expression in the samples from the horses with laminitis in this study. Medical doctors have used these compounds to understand the severity of these injuries in humans without using imaging or more invasive testing. Brooks hopes this could be used as a tool to monitor the progression of laminitis in the horse.

“We don't always recognize that a horse has severe laminitis until things have gotten quite bad,” said Brooks. “Early monitoring tools and ways to combat the disease were exciting findings, but we need further research before these new tools will be ready for use in the field.”

Brooks hopes that this research can lead to a blood test to detect these new laminitis-related biomarkers, and medications that are economical and effective for horses suffering from the disease.

“Ultimately, these new findings point us towards a more targeted approach for future exploration that we hope will help uncover novel solutions for preventing and treating this debilitating disease,” said Galantino-Homer.

“This is a big step in improving our understanding of laminitis,” said Brooks. “Something that could be completely untreatable ten years ago; in another ten years we may be able to intervene and make a significant difference in the disease early on.”

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Research Update: Cellular Mechanisms Of Laminitis

An international group of researchers recently proposed a theory to explain the cellular pathways involved in the development of laminitis, including the role of apoptosis, a normal process of self-destruction that helps eliminate damaged, superfluous, or unwanted cells. Unfortunately, their data showed that apoptosis did not influence the development of laminitis. Had their hypothesis held, however, targeted treatments for laminitis may have followed.

Laminitis is the painful separation of the lamellar layers of the hoof, which often results in profound lameness, prolonged and expensive supportive care, and possible euthanasia. Despite extensive research in this field, many of the underlying mechanisms associated with the development of laminitis remain unclear.

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The abovementioned theory proposed that sepsis-related laminitis, such as that induced by carbohydrate overload and black walnut exposure, involves apoptosis of cells that bind the lamellar layers of the hoof. The integrity of those cells helps suspend the third coffin bone inside the hoof. Researchers suggested that apoptosis occurs early in the disease process, even before signs of lameness manifest. Specifically, they proposed that exaggerated inflammation occurring with the presence of bacteria in the bloodstream could serve as a source of free radicals, which are known to induce apoptosis.

To test their theory, the researchers used hoof samples from horses subjected to carbohydrate overload or exposed to black walnut extract. Both models induce lamellar inflammation and sepsis. “When the researchers counted inflammatory and apoptotic cells microscopically, no increase in apoptosis was observed during either the development phase of laminitis or at the time of lameness onset,” relayed Whitehouse.

Though disappointing, these results sent researchers back to the drawing board in search of other mechanisms that contribute to the development of laminitis.

Meanwhile, horse owners must continue to employ management and nutritional strategies that keep horses safe from the ravages of laminitis. “In addition to avoiding management triggers, ensure horses have adequate nutrients to support the well-being of all body systems, including the integumentary system, which includes skin, hair, and hooves,” explained Catherine Whitehouse, M.S., a nutrition advisor for Kentucky Equine Research.

“To dodge potential nutrient shortages, all horses should receive a fortified feed suitable for their energy needs,” she said. This feed may come in the form of a traditional textured or pelleted concentrate or it may come as a balancer pellet, which is often useful for horses that can maintain their weight on forages alone.

Horses with compromised hooves may require additional support in the form of a high-quality hoof supplement. “A comprehensive hoof supplement provides more than just biotin to foster hoof growth and integrity. In addition to diet, routine management such as trimming or shoeing plays a vital role in maintaining and achieving hoof health that will also serve the horse well in the face of a laminitis episode,” Whitehouse explained.

Chronic inflammatory conditions, like laminitis, often respond to supplementation with omega-3 fatty acids, especially DHA and EPA. The omega-3s found in certain marine-derived products, like EO-3, are more available to horses than those found in plant-based sources.

^*Catunda, A.P.N., G.E.S. Alves, F.O.P. Leme, A.M. Carvalho, B.S. Leise, P.J. Johnson, and R.R. Faleiros. 2021. Apoptosis in epithelial cells and its correlation with leukocyte accumulation in lamellar tissue from horses subjected to experimental sepsis-associate

Reprinted courtesy of Kentucky Equine Research. Visit ker.com for the latest in equine nutrition and management, and subscribe to Equinews to receive these articles directly.

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