Sharp To Appeal Kentucky Levamisole Rulings

Days after the publication of stewards' rulings for five levamisole positives, counsel for trainer Joe Sharp says Sharp will be appealing those rulings. Attorney Clark Brewster told the Paulick Report Wednesday that the stewards erred when they wrote a series of decisions declaring the drug to be a Class B substance according to Kentucky's regulations.

“I found it to be extraordinarily unfair and damaging to Joe,” Brewster said. “It's just the intransigence of the stewards not having the courage to recognize the truth and to say, 'Ok, we're sorry about that. Let's get it right.'”

Levamisole is approved by the FDA for use in cattle, sheep, and goats as a dewormer. Brewster said Sharp had been advised to use it as a dewormer for his stable as part of an effort to switch between different anti-parasitic products. He purchased the product over the counter at Tractor Supply.

Managers and trainers have been advised for years not to use the same deworming products too frequently because there is a growing drug resistance among the most common parasites impacting horses. Most veterinarians have discouraged dewormer use according to schedule and instead suggest deworming based on fecal egg counts. The levamisole product used by Sharp came in a powder form and was mixed with water and given orally. Brewster said Sharp preferred this administration because he felt his horses got more complete doses of the drug than from traditional paste dewormers.

Sharp was hit with the levamisole positives in Kentucky around the same time he encountered issues with it in Louisiana, where eight horses were disqualified for post-race positives for the substance between Dec. 1 and Dec. 28, 2019. Sharp was later fined $1,000 for each violation there but was not issued a suspension. Louisiana regulates medication based on guidelines from the Association of Racing Commissioners International, which considers levamisole a Class 2 drug with a B penalty class. ARCI's schematic requires a minimum 15-day suspension and $500 fine for the first violation in the B penalty class.

Kentucky stewards ruled earlier this week to issue a $500 fine for each Kentucky positive and a 30-day suspension to be served concurrent for all five violations. The ruling cited mitigating circumstances, pointing out that he hadn't been notified of the first positive when the subsequent ones occurred.

Kentucky does not follow ARCI's classification guidance for medications and penalties, although there are many similarities between the two.

An important difference to Brewster is the history of changes of levamisole's classification. At one point, the drug was considered a Class A drug (the most serious category) and was later made a Class B. Then, in 2015, commissioners for the Kentucky Horse Racing Commission unanimously agreed to remove levamisole from the drug classification scheme altogether after they detangled the association between levamisole and another drug called aminorex. Aminorex is a stimulant which has the potential for performance enhancement and was the primary substance of concern, they concluded. Initially it had been unclear whether one was a sign that the other had been administered, but Brewster said it's now generally accepted that levamisole can metabolize into aminorex, but not the other way around.

(Read more about the challenges of regulating levamisole and aminorex in this 2018 feature.)

There is a provision in Kentucky's regulations allowing for some flexibility beyond the drug classification chart that's in the states regulations. If a substance comes up in a post-race test that isn't rated on the drug schedule — particularly a new designer drug — the commission can establish an appropriate classification after consulting with ARCI or the Racing Medication and Testing Consortium and call the positive.

But Brewster said this provision shouldn't allow the commission to declassify a drug, only to have stewards call it by its old classification and penalty years later.

“What about Panacur or ivermectin? The horsemen rely on the commission to tell them what they can and can't use. Why couldn't this man rely on what the commission tells him?” said Brewster. “I certainly believe if there's cheating going on or something to gain an advantage or mask pain when a horse shouldn't be running, let's get the classification schedule right, let's take action and police the sport in the most rigorous and fair way possible. This is a situation where somebody's made a terrible mistake and it's really impacted the trainer and they don't have the courage to retreat and do the right thing.”

He also said he notified the stewards of all this at the time of Sharp's hearing in December 2020 and was frustrated to see the ruling state levamisole as a Class B violation anyway. He questioned whether the stewards realized the drug had been delisted five years before.

“This is truly beyond the pale of regulation,” he said. “[The positives were] all over the news. Joe couldn't get stalls at Fair Grounds for a while. People pulled their horses, including one that ran in the Kentucky Derby (Art Collector). He was completely pilloried in the press, all on the basis that the stewards just didn't read the list.”

If the commission wanted to add levamisole back onto the drug classification schedule, Brewster believes the regulatory body should have gone through the usual rule-making process to do so.

“If that's the case, wouldn't we have an opportunity to say why it shouldn't be listed?” he said. “Wouldn't it be listed at a public hearing in the same fashion where it was delisted? But they just quietly wouldn't respond.”

The Kentucky Horse Racing Commission declined comment on Brewster's arguments, citing a policy of not commenting on active cases.

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Sharp Issued 30-Day Suspension, Fined For 2019 Levamisole Overages In Kentucky

Trainer Joe Sharp has been suspended 30 days for five levamisole positives from post-race test results in Kentucky in late 2019. Stewards' rulings published this week indicate Sharp waived his right to test the split sample in each case and was issued a $500 fine for each positive. He was also issued a 30-day suspension for each ruling, which will be served concurrently Feb. 12 through March 13 for all five violations.

The rulings covered the races of Zero Gravity in the ninth race at Churchill on Nov. 14, Chitto in the tenth race at Churchill on Nov. 22, Street Dazzle in the fourth race at Churchill Nov. 23, Blackberry Wine in the fifth race at Churchill Nov. 30, and Art Collector in the sixth race at Churchill Downs on Nov. 30, 2019. All horses have been disqualified from their placings in those races and purse money has been forfeited.

The stewards indicated mitigating circumstances in the case since Sharp was not notified of the first levamisole overage before the subsequent overages occurred. It is fairly common for racing officials to take the timing of overages into account if they occurred so close together that lab results would not be confirmed between the first and subsequent overages.

According to the Association of Racing Commissioners International, levamisole is a Class 2 drug and carries a B penalty, which means the minimum sanction is a 15-day suspension and $500 fine for the first violation.

Sharp had difficulty with levamisole elsewhere in late 2019. Eight of his runners were disqualified from races at Fair Grounds in New Orleans between Dec. 1 and Dec. 28, 2019 due to levamisole positives and he was fined $1,000 by stewards for each violation, though he was not suspended. Sharp told the media at the time he had been giving his horses a commercial dewormer product available at Tractor Supply for cattle but removed the product from all his barns on Dec. 12 after learning of the first positive test in Louisiana. According to the Racing Medication and Testing Consortium, levamisole has off-label uses in horses as a treatment for equine protozoal myeloencephalitis (EPM).

Sharp had a series of serious health setbacks in the months after the Kentucky findings, including two brain surgeries.

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Kentucky Regulators Express Concern About Fluphenazine And Its Considerable Staying Power

Members of the Kentucky Equine Drug Research Council voted Friday to withdraw existing guidance for racetrack practitioners about the use of fluphenazine after officials became aware that the drug can linger in a horse's body much longer than once thought.

Fluphenazine is used as an anti-psychotic drug in humans and a long-term sedative in horses. Under Kentucky's current guidance, it's considered a Class B drug, meaning it's considered to have a potential to influence racehorses' performance, but not as much potential as those drugs in Class A. Fluphenazine is an oil-based drug and is typically given subcutaneously, meaning under the skin.

Current guidance advises veterinarians to withdraw the drug seven days before a race. Dr. Bruce Howard, equine medical director for the Kentucky Horse Racing Commission, said he got a call from a practicing veterinarian a few months ago asking whether that guidance was correct, which prompted him to do a deep dive into the data available about fluphenazine use in horses.

What he discovered was that the seven day withdrawal suggestion on the books in Kentucky had been in place since 2004, before the advent of instrumentation testing for drugs in post-race samples. The ELISA kit method that was being used at that time was considerably less sensitive than current methods.

(Learn more about drug testing methods and why they matter in this 2014 Paulick Report feature.)

Howard found two unpublished studies, each consisting of only three horses, which claimed the drug could persist “for weeks” in the horse, while a conversation with California officials suggested it may even linger in a horse's system “for months.” That's because, in part, it has a very long half life, meaning the amount of time it takes for the total amount of the drug in the body to be reduced by 50%. While the half life for many drugs can be measured in hours, Howard's findings suggest that of fluphenazine could be 6.8 to 9.6 days. It's also possible that after an initial decrease in drug levels, fluphenazine concentrations might paradoxically increase again about 15 days after dosing.

Other racing groups have suggested that the drug be stopped for 45 to 60 days before racing, or possibly even longer.

“It appears to me from this information that the seven day withdrawal is really inadequate,” said Howard. “I don't think there's a credible study to make a withdrawal recommendation at this time.”

Instead, Howard suggests that trainers request a blood test on horses that have previously had fluphenazine before entering a race to verify whether they're under the required threshold in Kentucky. This could prove especially challenging in situations where a horse may have received the drug at the start of the year, gone to sale as a 2-year-old, and returned with an eye toward making a first start in April or May, as new connections may not know whether the drug had been given or not. In those scenarios, Howard said that a record of a treatment could serve as a “mitigating circumstance” for a trainer who had followed the seven-day guidance before the commission rescinded the guideline.

Fortunately, Howard said there have been no fluphenazine violations in Kentucky since 2009 and several veterinary members of the council agreed they don't think it's commonly used anymore for a variety of reasons.

The council agreed unanimously to rescind the seven-day guidance, on the condition Howard send additional warnings to practicing veterinarians about the issue.

The removal of the rule outlining the seven day guidance will now advance to the full Kentucky Horse Racing Commission for a vote before continuing through the legislature for final approval.

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Kentucky Supreme Court Declines To Review Historical Horse Racing Decision

The Kentucky Supreme Court issued a brief statement on Thursday in which it declined to reconsider the unanimous decision on historical horse racing machines issued on Sept. 24, 2020, reports the Courier-Journal. The request was issued by the Kentucky Horse Racing Commission and state's racetracks.

Meanwhile, legislative solutions to legalize historical racing machines are in the process of being crafted. Among the supporters of historical racing are Gov. Andy Beshear and Kentucky Senate Majority Floor Leader Damon Thayer.

“Our top priority for the 2021 legislative session is maintaining the status quo to ensure historical horse racing can continue operating in Kentucky as it has for the past decade,” Tonya Abeln, vice president of communications for Churchill Downs, Inc., told courierjournal.com. The preservation of the associated $5.2 billion economic impact statewide as well as the direct and indirect jobs of 60,000 Kentuckians impacted by HHR is now in the hands of the Kentucky General Assembly.”

Read more at the Courier-Journal.

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