Art Collector to Miss Kentucky Derby

Bruce Lunsford’s Art Collector (Bernardini) will not run in Saturday’s GI Kentucky Derby because of a minor foot issue, according to trainer Tommy Drury Tuesday. He said the winner of Keeneland’s GII Toyota Blue Grass S. and Runhappy Ellis Park Derby in his last two starts nicked the bulb of his left front heel with a hind hoof while galloping Monday at Churchill Downs. Because of horse racing strict medication rules, the horse could not be treated with an anti-inflammatory this close to the race.

“He grabbed himself [Monday] morning training,” Drury said. “It was still very sensitive this morning. When I took my thumbs to palpate the bulbs of his heels, you could still tell it was pinching him. I had to make a choice. Your horse has to always come first. To run in a race of this caliber and trying to compete against the best 3-year-olds in this country, you’ve got to be 110%. To me, it wouldn’t have been fair to Art Collector, even though it’s slight, knowing that there’s an issue of any kind. I had a meeting yesterday afternoon with my veterinarians,  Foster Northrup, Rick Costelle, had my blacksmith there. We discussed some different scenarios. We maybe could have put a bar shoe on it and stabilized it and he would have been fine. But you’re going to the Kentucky Derby. First and foremost, as the trainer, it’s my responsibility to be the voice for the horse. That’s just not fair to him [to run]. He’s been too good to us, and we’re going to make sure he’s taken care of first.”

Art Collector arrived at Drury’s Skylight training base in Oldham County, Kentucky Tuesday morning.

“I knew after we gave him a little anti-inflammatory this morning that he’d be perfectly sound,” he said. “That’s not surprising at all. And that’s what we wanted to see. We wanted to see him respond well to it, and it looks like that’s what happened. On to Baltimore.”

 

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Study: Lasers Help Heal Equine Tendon And Ligament Injuries

High-intensity laser therapy (HILT) can be used to reduce inflammation in horses that have tendon and ligament injuries, a study from Poland has found.

Drs. Paulina Zielińska, Jakub Nicpoń, Zdzisław Kiełbowicz, Maria Soroko, Krzysztof Dudek and Daniel Zaborski used 26 Warmbloods with tendon and ligament injuries to see if laser therapy could provide anti-inflammatory relief. All horses were between 5 and 24 years old and were patients at the Faculty of Veterinary Medicine at the Wroclaw University of Environmental and Life Sciences.

All horses were assigned to a group that received 15 HILT treatments or a group that received no laser treatments. All horses had the same 40-day rehabilitation program, which included one 20-minute walk on hard ground each day, followed by cold water application on affected tendons or ligaments. The injuries were assessed before and after treatment, and ultrasound images were taken.

The team concluded that HILT provided swelling and pain relief; the ultrasound images showed a reduction in lesion size in the horses treated with laser therapy, as well. The researchers say that HILT can be used as a supportive treatment for horses that have tendon and ligament injuries, reducing swelling and lameness, and improving pain. They note, however, that there is no protocol for the number of HILT sessions, duration, energy dose or frequency of treatment for horses that have tendon and ligament injuries.

Read more at HorseTalk.

Read the full study here.

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‘I’m Drawing This As The Line’: After Injury In Fall At Ellis, Trainer Larry Jones Finished Galloping

Trainer Larry Jones has long been well-known for galloping his own horses, and his unique long-stirrup and fast-moving style have always set his trainees apart in the mornings. Those days are now over for the 63-year-old, following a serious spill last Saturday at Ellis Park.

According to the Daily Racing Form, Jones was thrown from an unraced 2-year-old and suffered nine broken ribs, a broken collarbone, and a fractured vertebra. He's back at work already, but looking forward, the trainer plans to stick to the pony or stay on the ground.

Six years ago, Jones had to be placed in a medically-induced coma due to a severe head injury after a fall at Delaware Park.

“Every time I'd get hurt, all I'd think about was getting back up,” Jones told the Daily Racing Form. “But not any longer. I'm drawing this as the line. I've looked for the end of that racetrack for 40 years now, but I'm done looking.”

Read more at the Daily Racing Form.

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Promising Developments In Quest To Prevent Catastrophic Racehorse Injuries

Catastrophic injuries in Thoroughbred racehorses is a top-of-mind concern for the racing industry and for its fans. That sentiment is shared by researchers at the University of Kentucky, who are working to learn more about the changes happening at a cellular level that might indicate an injury is present before it becomes career or life ending.

Might it be possible to identify an early marker or signal for horses at risk of catastrophic injury, allowing for intervention before those injuries happen? And, if yes, might this type of detection system be one that could be implemented cost effectively on a large scale?

According to Allen Page, DVM, PhD, staff scientist and veterinarian at UK's Gluck Equine Research Center, the short answer to both questions is that it looks promising.

For the past three years, Page, along with UK colleagues, has been analyzing blood samples from more than 1,000 Thoroughbred racehorses. The samples, collected by participating racing jurisdictions from across the country, have come from both catastrophically injured and non-injured horses in a quest to better understand changes that might be happening at the cellular level during racing and if there are any molecular red flags which consistently differentiate horses that suffer a catastrophic injury.

An abstract of this research will be presented at the American Association of Equine Practitioners' annual meeting in December and more information about the study's findings will be shared this fall.

“We are definitely encouraged by our findings,” Page said. “The ultimate hope is, of course, to develop a screening tool that can be used pre-race to identify horses at increased risk for injury. The results of this study suggest that analysis of messenger RNA expression could be an economical, effective and non-invasive way to identify individual racehorses at risk for catastrophic injury.”

This study, as well as a follow up study beginning this month, has been entirely funded by the Kentucky Horse Racing Commission's Equine Drug Research Council.

“It is hard to overstate how much we appreciate the continued support of the KHRC and the Equine Drug Research Council. Their willingness to fund these projects is really a testament to their interest in supporting innovative ideas geared towards improving the safety and wellbeing of horses and riders,” Page said.

David Horohov,  PhD, chair of the Department of Veterinary Science, director of the Gluck Center and  Jes E. and Clementine M. Schlaikjer Endowed Chair, echoed those sentiments, “I am pleased that the EDRC is able to continue to provide support for this important study and that Dr. Page is able to continue his work on finding ways to protect our equine athletes.”

Joining Page in the research from UK's Gluck Center are Emma Adam, DVM, PhD, DACVIM, DACVS, assistant professor, research and industry liaison, Horohov, James MacLeod, VMD, PhD, John S. and Elizabeth A. Knight chair, director of UK Ag Equine Programs and professor of veterinary science and Ted Kalbfleisch, PhD, associate professor.

Previous research has shown that many catastrophic injuries occur in limbs with underlying and pre-existing damage, leading to the theory that these injuries occur when damage accumulation exceeds the healing capacity of the affected bones over time. Since many of these injuries have underlying damage, it is likely that there are molecular markers of this that can be detected prior to an injury.

The identification of protein biomarkers for these types of injuries had been explored in previous research, albeit with limited success. The focus of this project, measuring messenger RNA, had not yet been explored, however. The overall objective was to determine if horses that had suffered a catastrophic injury during racing would show increased inflammatory mRNA expression at the time of their injury when compared to similar horses who were not injured. It turns out that this theory might be on to something.

Messenger RNA (mRNA) is a single-stranded RNA molecule that is generated from DNA through the process of transcription. This mRNA carries the genetic information specifying a particular amino acid sequence, which can then be used to create a protein through the process of translation. While work looking at inflammation often involves measuring proteins, Page and his collaborators opted to focus on mRNA due to the limited availability of reagents available to measure horse proteins and concerns about how limited the scope of that research focus would be.  Focusing on mRNA expression, however, is not without issues.

According to Page, mRNA can be extremely difficult to work with. “A normal blood sample from a horse requires a collection tube that every veterinarian has with them. Unfortunately, we can't use those tubes because mRNA is rapidly broken down once cells in tubes begin to die. Luckily, there are commercially-available blood tubes that are designed solely for the collection of mRNA,” he said.

“One of the early concerns people had about this project when we talked with them was whether we were going to try to link catastrophic injuries to the presence or absence of certain genes and familial lines. Not only was that not a goal of the study, the samples we obtain make that impossible” Page said. “Likewise for testing study samples for drugs. The tubes do an excellent job of stabilizing mRNA at the expense of everything else in the blood sample.”

Horses eligible for inclusion in this study were Thoroughbreds entered into any race in one of five participating jurisdictions from September 2017 to June 2020. To look at the mRNA, these jurisdictions collected specific blood samples either pre-race or post-race from a selection of non-injured horses or immediately from a horse after a catastrophic injury. Once collected, samples were sent in batches to the Gluck Center where they were analyzed using quantitative PCR (qPCR). The names and category (injured, pre-race or post-race) of sampled horses were kept from the researchers by participating jurisdictions until the samples had been fully analyzed.

Once the names and dates of samples were revealed, public records were used to learn more about each horse. Information examined included the horse's sex, age, race type and whether non-injured horses raced again within three months of the sampled race. For horses who had been injured, more information about the race itself was gathered to determine if there were other factors related to the injury.  Additionally, necropsy results, when available, were used to categorize the type of musculoskeletal injury that occurred.

“As of right now, there are four mRNA markers, out of the 23 we have measured with qPCR, that show some significant promise as markers for identifying horses at risk of a catastrophic injury. Obviously, there has been an impact of COVID-19 on our research, so there are still a few more samples to process and add to our data analysis. Once we do that, we plan to submit the findings for publication. Currently, we're targeting the end of the year to be able to share exactly what we have found so far” Page said.

Read more here.

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