First Inhaled Therapy For Severely Asthmatic Horses Launched In U.S.

Boehringer Ingelheim today announced the U.S. launch of the Aservo EquiHaler (ciclesonide inhalation spray), the first FDA-approved inhalant therapy for horses with severe equine asthma.

Developed after a decade of collaboration between Boehringer Ingelheim's human pharmaceutical and animal health businesses, the Aservo EquiHaler offers the promise of relief to thousands of horses that suffer from severe equine asthma, which affects 11 to 17 percent of horses.

Horses with severe equine asthma typically have clinical signs that include difficulty breathing, coughing and nasal discharge, which can have a significant impact on a horse's performance and quality of life. Over time, severely asthmatic horses may develop changes in the lung, which makes it difficult to breathe, even at rest.

“We understand the unique and inextricable link between animals and people. By delivering value through innovation, we strive to enhance the wellbeing of both and help shape the future direction of the industry,” said Caroline Belmont, Head of US Global Innovation and US Regulatory Affairs at Boehringer Ingelheim Animal Health. “We are focused on developing breakthrough therapeutics, like the Aservo EquiHaler, for animal disease areas with unmet needs to make a true impact in the lives of horses and their owners.”

The Aservo EquiHaler marks an industry first in equine medicine, as until now, there has been no FDA-approved inhalant therapy for use in horses with severe equine asthma. Severe equine asthma is an inflammatory disease of the lower airways caused by breathing in high concentrations of organic dust particles small enough to pass with air to the lower airways. Such particles are commonly found in hay and bedding.

Boehringer Ingelheim Animal Health used the Respimat inhaler, developed by the company's human pharmaceutical business, as a basis to develop the unique Soft Mist Technology of the Aservo EquiHaler, which is designed specifically for use in horses. The Aservo EquiHaler includes an ergonomic handle and dosing lever for ease of user handling, and a nostril adapter that fits inside the nostril of the horse, allowing them to easily inhale the medicated mist into their lungs.

The active ingredient in the Aservo EquiHaler (ciclesonide inhalation spray) is ciclesonide, a glucocorticoid (steroid) that becomes activated in the lungs, which allows for the targeted delivery and activation of the medication. Studies in horses with severe asthma have demonstrated that administration of ciclesonide reversed airway obstruction associated with severe asthma, and to date, ciclesonide is the only glucocorticoid not associated with suppression of serum cortisol, a desired treatment outcome.

To learn more about Aservo EquiHaler, click here.

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Into Mischief Continues His Commercial Ascent At Keeneland September Sale

The past 12 months have seen Spendthrift Farm's flagship sire Into Mischief achieve just about everything a stallion needs to do in order to be considered a major commercial sire.

Let's go down the list:

Breeders' Cup winner? Check.

Eclipse Awards? Covfefe got him two for good measure.

Leading sire title? He earned his first at the end of 2019.

Classic winner? Authentic went from the outside post to the history books earlier this month.

With that kind of momentum behind him, the next step was to have a big showing at this year's Keeneland September yearling sale. Another box, another check.

During Monday's session alone, Into Mischief had three yearlings bring seven-figure prices, adding to the one he hammered down on Sunday's opening day of trade. His four total seven-figure offerings tied him with Medaglia d'Oro for the most by a sire at Keeneland September through the end of Book 1. Prior to this year, his million-dollar yearling club consisted of a single horse.

If there was any remaining doubt that Into Mischief has earned his place among the the very top echelon of North America's commercial sires, it was pulverized with every seven-figure fall of the hammer.

“It's just building on what he's done,” said Spendthrift Farm general manager Ned Toffey. “He's always been a commercial horse, but when you win the Derby and you show people that you're able to get a classic horse, which was sort of the only question left unanswered with him, this has just given people that much more confidence to go out and ante up for a really nice Into Mischief. That's great news for us, it's great news for our breeders, and we couldn't be happier with it.”

The leader of the pack for Into Mischief through the end of Book 1 at the Keeneland September sale was Hip 438, a filly out of the Grade 2-placed stakes-winning Medaglia d'Oro mare Taylor S who sold to Larry Best's OXO Equine on Monday for $1.9 million, the second-highest overall price for both the day and the sale.

Taylor S is a half-sister to Breeders' Cup Dirt Mile winner Liam's Map and Grade 3 winner Not This Time, who have both gotten off to fast starts as stallions. Taylor Made Sales Agency consigned the top filly, as agent.

It was the second Into Mischief yearling Best purchased at the sale, after landing Hip 121, a colt out of the Grade 2-placed Cuvee mare Curlina, for $1 million on Sunday. He was handled by Gainesway, agent.

Elsewhere, Courtlandt Farm bought Hip 275, a filly out of the stakes-placed Distorted Humor mare Mary Rita, while BSW/Crow Bloodstock landed Hip 405, a filly out of the Unbridled's Song mare Special Me whose siblings include Grade 1 winner Gift Box and Grade 2 winner Stonetastic. Both yearlings were purchased for $1,025,000.

The performance by Into Mischief's yearlings during the Keeneland September sale carries on the momentum set last week during the Fasig-Tipton Selected Yearlings Showcase, where he had 17 yearlings sell for a combined $6,745,000, led by a colt out of the Distorted Humor mare Blind Copy who sold to the partnership of SF Bloodstock, Starlight Racing, and Madaket Stables for $800,000.

Had the yearling season ended after just the two days of the Fasig-Tipton sale, Into Mischief's 2019 foal crop would have been the fourth-highest out of his 10 crops to reach the market by number of horses sold at upper price points ($750,000 and up, $500,000 and up, or $250,000 and up). After two more days of selling at the market's highest level, this season's crop of yearlings sits second or third in those three categories, with a solid chance of finishing the year safely in first across the board.

With 2020 being an unprecedented year in practically every aspect of the Thoroughbred industry, Into Mischief was also the beneficiary of arguably the biggest update a sire has ever received heading into the yearling season: Authentic's victory in the postponed Kentucky Derby, just days before selling began.

With that being said, Toffey said a Derby winner alone doesn't guarantee an immediate spike in returns.

“The 'Derby bump' doesn't happen without the stock out here that he's got,” he said. “As his stud fee has gone up, the mare quality has gotten better, the individuals have gotten better, and that just continues to happen.

“That's the thing that's been remarkable over the years – not every stallion improves as the mare quality improves, but he's continued to do that,” Toffey continued. “In his second year, his stud fee was as low as $6,500, and all the way right up to last year at $175,000, the mare quality continues to go up and the quality of the offspring just continues to look better, and they continue to perform better. We're just glad he's on our team.”

Into Mischief's average yearling sale price reflects the stallion's climb up the commercial ladder. His first crop of yearlings saw 26 members go through the ring in 2011 for an average price of $22,792.

A year later, his second crop had 13 yearlings average $21,269 from combined revenues of $276,500 – all their respective lowest points. Into Mischief's average yearling sale price in 2019 was greater than his combined second-crop gross from 2012, and he stands a good chance of surpassing that threshold for a second time this year, continuing a journey to the top of the marketplace that seemed like a pipe dream a decade ago.

“That's the great thing about this game,” Toffey said. “You're always hoping for the best, you're shooting for the stars, and most of the time, you don't get these kind of results. Horses like Into Mischief just don't come along very often. He's just been remarkable. We thought we had the horse of a lifetime with Malibu Moon, and we've got another one with Into Mischief.”

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Little Red Feather Racing Hires Compliance Consultant To Oversee Operations

In what is presumed to be the first hire of its kind, Little Red Feather Racing (LRF), California's largest horse racing syndicate, on Tuesday announced the hiring of an independent compliance consultant to oversee all aspects of its racing and sales divisions. The consultant will ensure that LRF's trainers, veterinarians, and staffs comply within regulatory rules as well as LRF's internal policies regarding training and medication.

“Many industries have compliance managers, why not horse ownership?” said LRF Managing Partner Gary Fenton. “We want our partners to have the utmost confidence and trust that our equine athletes receive world-class care.”

“It's time we take a long hard look at everything we provide to our equine athletes,” said LRF Founder and Managing Partner Billy Koch, “Current training practices need to evolve with changing times.”

Effective immediately, Tom McCrocklin will serve as compliance consultant for the LRF team and report directly to Fenton and Koch.

Born in Baton Rouge, La., McCrocklin has an undergraduate degree from LSU and a Bachelor of Science in Animal Science, specializing in equine from Louisiana Tech. McCrocklin trained at east coast race tracks until 1992 where he moved to Ocala, Fla., to commence a breaking/training/sales operation, representing some of the biggest names in the industry.

McCrocklin will review veterinarian and training bills as well as regularly visit each LRF barn.  He will work alongside LRF's trainers and vets to create a universal set of protocols.  “Since I am a trainer and understand the culture and mentality, I look forward to working with my colleagues to create a methodology that is positive for everyone,” said McCrocklin. “Most trainers want to learn and try less medications and supplements; they just need the educational and support tools to do so.”

“Too often we hear discussion about a problem in our industry, yet rarely is there a solution posed,” said Jim Gagliano, president of The Jockey Club. “Today is not that day. We applaud LRF for taking this innovative step and showing that owners can and will take measures to ensure best practices are being met within our industry.”

Formed in 2002, LRF and its sister company Solana Beach Sales (SBS) are California's largest syndicate, managing nearly 100 horses and over 300 active partners. LRF recently concluded a record breaking summer in 2020 with 11 wins at Del Mar from its managed partnerships, including wins in the G2 Del Mar Handicap – a Breeders' Cup Win and You're In race – with Red King, and the G2 John C Mabee Stakes with Raymundos Secret. LRF campaigned Breeders' Cup Winner Singletary and G1 winners Egg Drop, Secret Spice, Fault, Mirth and stallion Midnight Storm. SBS burst onto the sales scene in 2016 and graduates include G1 winners Instilled Regard, Bast and G1 placed Anneau D'Or who finished 2nd in the Breeders' Cup Juvenile at the 2019 World Championships.

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