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Can Exercise Protect Foals From Injuries Later In Life? Tune In To Find Out

Does exercise help young horses avoid injury? That's the topic of this month's episode of Morris Animal Foundation's “Fresh Scoop” podcast, available now for streaming and download. Host Dr. Kelly Diehl, the Foundation's Senior Director of Science and Communications, interviews Dr. Annette McCoy, Assistant Professor of Equine Surgery at the University of Illinois at Urbana-Champaign College of Veterinary Medicine.

McCoy discusses leg fractures in horses and her new Foundation-funded study, which is evaluating the long-term effects of a moderately strenuous exercise plan on bone development in foals. Her team is collecting data for an algorithm they hope to use to design exercise programs for foals to reduce risk of injuries later in life.

Dr. McCoy is a Diplomate of the American College of Veterinary Surgeons.

“Fresh Scoop” is Morris Animal Foundation's monthly veterinary science podcast designed to appeal to practicing veterinarians, veterinary technicians or students, as well as animal-loving science geeks. Episodes are available on iTunes, Spotify, and Stitcher, as well as the Foundation's podcast page.

Bacterial Infection Linked To Abortions In Japanese Mares

Mycobacterial infections, which are generally uncommon in horses, have been linked to ten abortions in Japanese mares. The mares were housed on seven Thoroughbred farms in the Hidaka district of Hokkaido. There were no reports of direct contact between the horses.

Dr. Yuta Kinoshita studied the abortions, which took place from 2018 to 2019. Most of the placentas had a yellowish-white exudate on them and included considerable lesions. Lesions aren't common with pathogenic bacteria like Streptococcus zooepidemicus and Escherichia coli.

Researchers located Mycobacterial granulomas on the placenta and the fetal organs. Bacterial samples were taken from both of these areas, with the greatest number of bacteria found in the necrotic placental lesions. The bacteria were genetically tested and identified as Mycobacterium avium subsp. hominissuis. The strains were all identical, suggesting that the horses had been infected by the same unknown contagious source.

Read the case report here.

Hormones Play A Role In Foal Rejection

Foaling can be a high-stress situation with a lot of variables that may go wrong, from dystocias to ill foals. Though most mares have an innate mothering mentality, some mares reject their offspring and the exact reason is unclear, making it difficult to prevent.

Drs. Dalia Berlin, Amir Steinman and Tal Raz conducted a study using eight Arabian mares who behaved normally after foaling and 15 Arabian mares who typically “rejected” their foals. Rejection includes refusing to let the foal nurse, indifference toward the foal and even attacking the foal. The Arabian was chosen specifically for the study as rejection behavior in mares has been well documented in the breed.

Each mare had blood drawn at the first and third day after foaling; the blood was tested for progesterone, prolactin and estradiol, which are reproductive hormones. The most significant difference between the two groups was the estradiol-to-progesterone ratio the first day after foaling was significantly lower in mares that rejected their foals than in mares with normal maternal behavior.

The exact role the hormones play in maternal behavior is unclear, but the ratio of hormones in mare that rejected their foals increased in the three days post foaling, suggesting that the hormones may normalize and the rejection behavior may diminish.

The study team notes that the creation of hormonal treatments for rejecting mares is premature as the optimal concentration for each hormone is yet unknown.

UK Gluck Center And Industry Leaders Responding To An Uptick Of Foal Diarrhea Cases

The first several months of the year make up the bulk of the busy foaling season in Central Kentucky, so when the region's farms and equine practitioners began noticing increases of diarrhea in foals ages two to seven days old, there was concern.

In response, the University of Kentucky Gluck Equine Research Center is using a portion of its existing Koller Emergency Funds, and the Kentucky Thoroughbred Owners and Breeders Foundation, Grayson-Jockey Club Research Foundation and Coolmore America are leading an effort to help provide additional funding, allowing research to begin immediately.

“Anytime we recognize an increased incidence in equine health cases, such as foal diarrhea, we prepare and mobilize to further our understanding of the health issue,” said David Horohov, chair of the Department of Veterinary Science and director of the Gluck Equine Research Center. “Early detection and rapid diagnostics are at the cornerstone of what drives our research approach.”

Foals commonly develop diarrhea a week to 10 days after foaling, and veterinarians and farm owners typically have the experience and tools to respond. According to the American Association of Equine Practitioners, it is important for a veterinarian to evaluate foals under a month old when they experience diarrhea because they can develop life-threatening dehydration in as few as six to eight hours. Neonatal or young foals have a digestive tract, similar to humans, where small intestines are responsible for much of their nutrition absorption. Dealing with this type of attack on the small digestive system heavily impacts foals, which is a big reason why the Gluck center will focus its research efforts on this issue.

A significant increase in the illness has affected some farms, while other farms have had few to no cases. In spite of these incidences, UK has not recognized a rise in reported mortality associated with these cases and continue to monitor the situation.

UK College of Agriculture, Food and Environment researchers have developed a multipronged research plan to help further the understanding of the problem.

One focus of this research plan is to expand scientists' knowledge of the foal gut environment. This will add to their understanding of neonatal gut bacteria and the effect of antibiotic treatment.

A second part of the research plan is to study the differences in mares and their foals on farms both with and without early neonatal diarrhea cases and the effect of antimicrobial drug treatment. Researchers will conduct this analysis through gene sequencing to determine an overview of type and diversity of gut microflora.

They will also use the data in this part of the study to gain insight into the effect of antimicrobial use in foals on the development of their gut microflora.

The third prong of the research will investigate a biotherapeutic approach on one farm. That farm is supplementing foals with home-fermented live yogurt instead of a commercial pre/probiotic. Research has shown that Lactobacillus spp. bacteria are among the first colonizers in the neonatal gut. Data from other species supports Lactobacillus spp. as promoting gut health and outcompeting pathogens in gut colonization.

In addition to the three studies, the UK Gluck Center and Veterinary Diagnostic Laboratory team has identified further potentially useful tests, including gene sequencing targeting identification of novel viruses and bacteria that may be present.

With limited Koller Emergency Funds available, the UK Gluck Equine Research Center is thankful for the additional dollars provided by the Kentucky Thoroughbred Owners and Breeders Foundation, The Grayson-Jockey Club Research Foundation and Coolmore America.

“The foundation members met March 15 and felt this research and timing was consistent with the sole mission of immediately responding to threats to the breeding industry in Central Kentucky. We are grateful to Gluck for accessing their emergency funds and everyone for responding so quickly.” said Jimmy Bell, chairman of the KTOB Foundation.

“Situations such as these highlight the relevance for a coordinated effort that can be led by our scientists at the Gluck Equine Research Center,” said Stuart Brown, veterinarian, Keeneland equine safety director and chair of the Gluck Research Foundation. “Our team mobilizes to work with equine practitioners and farms throughout the area, allowing us to further our understanding and develop our approach to work on these types of issues. We appreciate the opportunity to collaborate with other partners to enhance our abilities when issues like this arise.”

“We at Grayson-Jockey Club Research Foundation believe in supporting timely equine health for all horses at every stage of their lives, and foal diarrhea is proving to be a concern this year on Central Kentucky farms,” said Dell Hancock, chair of the foundation. “We are happy to help facilitate research to address this condition and thank the University of Kentucky's Gluck Equine Research Center for their commitment to the well-being of horses.”