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AAEP Publishes Contagious Equine Metritis Guidelines

Comprehensive guidelines to assist veterinarians with identification, diagnosis and control of Contagious Equine Metritis (CEM), a non-systemic venereal disease of equines that causes short-term infertility in mares and rare abortion, are now available on the AAEP's website.

Six outbreaks of CEM have occurred in the U.S. in the past 15 years, including a significant outbreak in 2008 to 2010 in which over 1,000 exposed horses in 48 states were required to be tested, resulting in 23 contaminated stallions and five infected mares ultimately identified and treated.

“Outbreaks in the U.S. have demonstrated the risk of incursions and the need for surveillance in the active breeding population to identify cases early and limit disease spread,” said guidelines co-author Dr. Abby Sage, Richmond staff veterinarian for the Virginia Department of Agriculture and Consumer Services. “Several of these outbreaks also demonstrated significant stallion-to-stallion spread of Taylor equigenitalis via fomites and inadequate biosecurity during semen collection and stallion handling.”

Dr. Sage and co-author Dr. Peter Timoney, the Frederick Van Lennep Chair in Equine Veterinary Science at the University of Kentucky's Gluck Equine Research Center, advise equine practitioners and stallion owners/managers to follow stringent biosecurity protocols when collecting and handling stallions and consider implementation of annual testing of active breeding stallions prior to breeding season as ongoing assurance of disease freedom.

CEM is an internationally reportable disease. When the carrier status of a stallion or infection of a mare is suspected, practitioners should contact their state and/or federal animal health official, who will provide current collection and response procedures for suspect cases.

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The CEM Guidelines were reviewed and approved by the AAEP's Infectious Disease Committee and board of directors. View the guidelines or save them to your mobile device for future reference here.

Besides CEM, AAEP guidelines for 22 additional equine infectious diseases are available here.

Research Update: Cellular Mechanisms Of Laminitis

An international group of researchers recently proposed a theory to explain the cellular pathways involved in the development of laminitis, including the role of apoptosis, a normal process of self-destruction that helps eliminate damaged, superfluous, or unwanted cells. Unfortunately, their data showed that apoptosis did not influence the development of laminitis. Had their hypothesis held, however, targeted treatments for laminitis may have followed.

Laminitis is the painful separation of the lamellar layers of the hoof, which often results in profound lameness, prolonged and expensive supportive care, and possible euthanasia. Despite extensive research in this field, many of the underlying mechanisms associated with the development of laminitis remain unclear.

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The abovementioned theory proposed that sepsis-related laminitis, such as that induced by carbohydrate overload and black walnut exposure, involves apoptosis of cells that bind the lamellar layers of the hoof. The integrity of those cells helps suspend the third coffin bone inside the hoof. Researchers suggested that apoptosis occurs early in the disease process, even before signs of lameness manifest. Specifically, they proposed that exaggerated inflammation occurring with the presence of bacteria in the bloodstream could serve as a source of free radicals, which are known to induce apoptosis.

To test their theory, the researchers used hoof samples from horses subjected to carbohydrate overload or exposed to black walnut extract. Both models induce lamellar inflammation and sepsis. “When the researchers counted inflammatory and apoptotic cells microscopically, no increase in apoptosis was observed during either the development phase of laminitis or at the time of lameness onset,” relayed Whitehouse.

Though disappointing, these results sent researchers back to the drawing board in search of other mechanisms that contribute to the development of laminitis.

Meanwhile, horse owners must continue to employ management and nutritional strategies that keep horses safe from the ravages of laminitis. “In addition to avoiding management triggers, ensure horses have adequate nutrients to support the well-being of all body systems, including the integumentary system, which includes skin, hair, and hooves,” explained Catherine Whitehouse, M.S., a nutrition advisor for Kentucky Equine Research.

“To dodge potential nutrient shortages, all horses should receive a fortified feed suitable for their energy needs,” she said. This feed may come in the form of a traditional textured or pelleted concentrate or it may come as a balancer pellet, which is often useful for horses that can maintain their weight on forages alone.

Horses with compromised hooves may require additional support in the form of a high-quality hoof supplement. “A comprehensive hoof supplement provides more than just biotin to foster hoof growth and integrity. In addition to diet, routine management such as trimming or shoeing plays a vital role in maintaining and achieving hoof health that will also serve the horse well in the face of a laminitis episode,” Whitehouse explained.

Chronic inflammatory conditions, like laminitis, often respond to supplementation with omega-3 fatty acids, especially DHA and EPA. The omega-3s found in certain marine-derived products, like EO-3, are more available to horses than those found in plant-based sources.

^*Catunda, A.P.N., G.E.S. Alves, F.O.P. Leme, A.M. Carvalho, B.S. Leise, P.J. Johnson, and R.R. Faleiros. 2021. Apoptosis in epithelial cells and its correlation with leukocyte accumulation in lamellar tissue from horses subjected to experimental sepsis-associate

Reprinted courtesy of Kentucky Equine Research. Visit ker.com for the latest in equine nutrition and management, and subscribe to Equinews to receive these articles directly.

The post Research Update: Cellular Mechanisms Of Laminitis appeared first on Horse Racing News | Paulick Report.

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Deadly Virus Found In New York Mosquitoes

Aerial spraying of Oswego County, New York, has begun after Eastern equine encephalitis (EEE) was found in the county's mosquito populations.

EEE is a rare virus spread through the bite of infected mosquitoes, not just for horses, but for humans as well. The virus can cause brain swelling and is often fatal. The New York Department of Health reported EEE as an “imminent threat to public health.”

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Between two and five people die from EEE in the United States each year, report the U.S. Centers for Disease Control. In 2019, 19 people died from EEE.

Aerial pesticide spraying is a temporary measure to combat EEE and residents should remain diligent in their efforts to reduce exposure to mosquitoes.

Study: Thailand’s African Horse Sickness Outbreak Likely Started From Just One Animal

Scientists have found that the 2020 outbreak of African Horse Sickness in Thailand most likely came from just one affected animal entering the country. Hundreds of horses were killed in the country's first outbreak of the disease, which is spread by biting midges.

Dr. Napawan Bunpapong and a research team from Chulalongkorn University in Bangkok used molecular-based testing to help determine the disease's origin. They discovered that every blood and tissue sample taken from affected horses in Thailand contained the virus, and more specifically, contained unique amino acids, indicating a single, common origin. The researchers suggest that the virus may have come from an asymptomatic animal like a zebra.

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The government of Thailand restricted movement and enforced quarantine, disinfection and vector control to try to staunch the spread of the disease. Mass vaccination was also completed in Thailand and neighboring countries.

Affected horses had a fever and swelling near their eyes; they became depressed and short of breath before dying suddenly within 48 hours.