Same Rules, New Lab: Maryland’s Leading Trainer Gonzalez Notified Of Two Dexamethasone Positives

Claudio Gonzalez, Maryland's leading trainer for the last four years, scratched all six of his runners entered to race on Sunday, July 4, at Pimlico racetrack in Baltimore, Md., after being notified of two positive tests for the corticosteroid dexamethasone.

Gonzalez said he learned of the positive tests on Saturday, July 3. That night, the Maryland Thoroughbred Horsemen's Association issued the following advisory to trainers:

“Horsemen are advised of the following regarding the use of dexamethasone, a commonly used corticosteroid with anti-inflammatory properties.

“Dexamethasone has a 72-HOUR withdrawal guideline for intramuscular and intravenous administration of dexamethasone sodium phosphate or oral administration of dexamethasone. The dosing specification is 0.05 milligrams per kilogram regardless of the route of administration.

“Under the Association of Racing Commissioners International Uniform Classification Guidelines and Recommended Penalties Model Rules, dexamethasone is a Class 4 substance in the Class C penalty category. In Maryland, a first offense carries a minimum fine of $1,000 absent mitigating circumstances for a trainer and disqualification of the horse and loss of purse.”

Gonzalez admitted that the veterinarians he employs were giving the anti-inflammatory at 48 hours, but with a lower dose.

“The recommendation is 72 hours and 22 milligrams,” said Gonzalez. (Note:  the .05 milligram per kilogram dosing specification converts to about 22 milligrams for a 1,000-pound horse.) “We go 48 hours and give only 10 (milligrams). We give half at two days. Since 2014, they (the vets) have done the same. They've treated 3,000 horses a year from 2014 and never had one positive in Maryland until now.”

These would be the first medication charges against Gonzalez since he received a warning in 2016 for an overage of the ulcer treatment, omeprazole – the only medication violation on his record at www.thoroughbredrulings.com.

Dexamethasone guidelines in Maryland have not changed recently, according to J. Michael Hopkins, executive director of the Maryland Racing Commission.

What has changed is Maryland's official testing lab. Hopkins said when the contract with Truesdail Laboratories of Irvine, Calif., expired in April 2021, the commission switched to Industrial Laboratories in Wheat Ridge, Colo. No formal announcement or advisory on the change of labs was issued by the commission or Maryland Thoroughbred Horsemen's Association.

“They changed the lab,” said Gonzalez. “It can be a big difference.”

Several states have now dropped Truesdail as their official testing laboratory since a 2015 quality control audit by the Indiana Horse Racing Commission found that seven positive tests were missed over a 26-day period, including two for betamethasone. Indiana switched to Industrial, as did the West Virginia Racing Commission. The Arkansas Racing Commission had its testing shifted to Industrial after Truesdail's accreditation was suspended in April 2020 by the Racing Medication and Testing Consortium. Truesdail  has not sought to re-gain its RMTC accreditation.

Shortly after the switch from Truesdail to Industrial, Hopkins said, an unspecified number of positives for Amicar, an adjunct bleeder medication, were called. The Maryland Thoroughbred Horsemen's Association then issued the following advisory:

“Effective immediately, horsemen are urged to discontinue the use of any and all adjunct bleeder medications for horses in training, including in particular, aminocaproic acid—commonly called Amicar.

“Amicar and several other adjunct bleeder medications were placed on the Prohibited List in 2013 under the Association of Racing Commissioners International Uniform Classification Guidelines for Foreign Substances and Recommended Penalties Model Code and the National Uniform Medication Program. Aminocaproic acid, for example is a Class 4 substance and penalty Class C.

“It is important to understand that these medications cannot be regulated by withdrawal time guidance and/or a testing threshold and their use, no matter how far in advance of a race, may trigger a positive post-race test.

“Any trainer who chooses to continue the use of these medications for training in the future will run the risk of a post-race positive test.”

Hopkins said he couldn't comment on any specifics involving the Amicar or dexamethasone positives because of ongoing investigations.

Gonzalez is leading the current Laurel and Pimlico meeting with 27 wins from 110 starts, more than doubling the number of wins by his closest pursuers. Gonzalez said he plans to ask for a split sample to confirm the findings by Industrial and fight the charges if a formal complaint is filed against him.

The post Same Rules, New Lab: Maryland’s Leading Trainer Gonzalez Notified Of Two Dexamethasone Positives appeared first on Horse Racing News | Paulick Report.

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About That Connection Between SGF-1000 And Dexamethasone

When news broke last weekend that Medina Spirit had tested positive for the corticosteroid betamethasone, Paulick Report staff received several questions from readers asking about a phone conversation intercepted by federal agents. Court documents from the federal indictments of March 2020 recalled a conversation between trainer Jason Servis and veterinarian Dr. Kristian Rhein in which they were discussing a substance called SGF-1000, which prosecutors say was one of the misbranded or adulterated drugs at the heart of the case. Rhein told Servis that the substance could sometimes create a false positive for “dex,” widely believed to refer to dexamethasone, and Servis asked Rhein to alter his veterinary records to make it appear as though horses had been treated with dexamethasone in case of a positive test.

Read more about SGF-1000 in this Paulick Report feature.

Since both dexamethasone and betamethasone are corticosteroids, some readers wondered whether a positive test for betamethasone could actually be a guise for something more sinister.

According to Dr. Mary Scollay, executive director for the Racing Medication and Testing Consortium, the answer is no.

Scollay explained that the testing and confirmation process used in mass spectronomy makes it virtually impossible for one drug to be misidentified as another. She doesn't believe betamethasone is a false positive result, nor that SGF-1000 could actually have shown up as dexamethasone in post-race tests. (No one ever said the indicted individuals were always accurate in their intercepted conversations.)

Mass spectronomy works by identifying foreign molecules inside blood or urine and weighing them as part of a process called screening analysis. Those molecular weights are then checked against the lab's drug catalogue. The catalogue contains the molecular weights of known substances and is developed through rigorous testing of known drugs. If a molecular weight matches something in the catalogue, that's an initial finding.

Before the lab can actually call the test a positive for the substance though, it goes through a second process called confirmatory analysis. It's possible two substances could have the same weight but be made up of different components, so the lab must find out if their compositions are the same. In this process, the molecules of the substance are bombarded with energy until they split apart, and the ratios of the resulting pieces are measured against the catalogued substance.

“Each specific molecule has its own way of fragmenting,” said Scollay. “It's like a Hershey bar – it's scored in a certain way, it's going to break the same way every time if you apply force at certain points. When you go to identify the molecule, you look at the candidate ions, the ions that result from fragmenting it, and also the ratio of those ions to each other. They should be present in very specific proportions. If they're not, or if the candidate ions are not present, or even one of them is missing, you have not identified the substance.

“I would argue that if you identify the candidate ions in the right ratio, you've identified betamethasone.”

By the time a lab calls a positive using this testing method, it's justifiably confident that the substance at play has been correctly identified.

So what of the SGF-1000/dex connection?

“Maybe dexamethasone was in the SGF-1000, and that's why they said it would show as dexamethasone, but if a molecule has the same exact molecular weight as dexamethasone and you apply energy to it and it fragments, and the fragmented parts are the ions you would get from dexamethasone in the relative concentrations, I'm going to say you've identified dexamethasone,” she said.

The post About That Connection Between SGF-1000 And Dexamethasone appeared first on Horse Racing News | Paulick Report.

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Diodoro has Third Winner This Week DQ’d for Drug Positive

For the third time as many days this week, the nation’s third-leading trainer by wins for 2020 has been fined and had a winner disqualified for a Class 4 drug positive.

According to a Sept. 2 ruling issued by the Oklahoma Horse Racing Commission, the Robertino Diodoro-trained Erebuni (Ministers Wild Cat) came up positive for dexamethasone in post-race serum testing after winning the 10th race at Will Rogers Downs May 4. The race was a $5,000 NW4L claimer in which the mare was favored at 19-10 odds.

Dexamethasone is an anti-inflammatory listed as a Class 4/Penalty Category C prohibited substance on the Association of Racing Commissioners International’s uniform classification guidelines for foreign substances.

According to the ruling, Diodoro declined the opportunity to have a split sample tested, waived his right to a hearing, and pled “no contest.”

In addition to owner Empire Racing Stables, LLC, (Jason Bullard) losing the $4,614 winning purse for Erebuni’s DQ, Diodoro was fined $1,000.

Erebuni has started and lost three consecutive races since that May 4 win, shipping most recently to Evangeline Downs in Louisiana. But the ruling states that the mare must now work out and be examined by a commission veterinarian (at the owner and/or trainer’s expense) before being allowed to race again.

On Aug. 31, Diodoro had two winners and a fifth-place horse disqualified from Oaklawn Park races via rulings that cited prohibited use of two different Class 4 substances. Diodoro was separately fined $3,500 for failing to meet the “absolute insurer” requirements of a trainer licensed by the Arkansas State Racing Commission.

The post Diodoro has Third Winner This Week DQ’d for Drug Positive appeared first on TDN | Thoroughbred Daily News | Horse Racing News, Results and Video | Thoroughbred Breeding and Auctions.

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