Vets’ Attorney in Bisphosphonate Suspension Says Drs. Followed the Rules

The attorney for veterinarians Scott Shell and Barbara Hippie, who have been provisionally suspended by the Horse Racing Integrity and Welfare Unit (HIWU) for possession of bisphosphonates and two other medications told the TDN Saturday morning that the veterinarians were operating under the rule as published.

“Drs. Shell and Hippie vehemently deny any violation of the veterinary rules as posted pursuant to HISA,” said Drew Mollica by phone Saturday. “We look forward an immediate hearing so that all of the facts may be explored and their good names and reputations restored. Dr. Shell's practice is known for its integrity, and any substances in his possession were used properly, and were in his possession pursuant to the rules.”

Covered horses are defined by the Horseracing Integrity and Safety Authority “any Thoroughbred horse, or any other horse made subject to the Act by election of the applicable State Racing Commission or the breed governing organization for such horse under section 3054(l), during the period: (A) beginning on the date of the horse's first Timed and Reported Workout at a Racetrack that participates in Covered Horseraces or at a training facility; and (B) ending on the date on which the horse is deemed retired.”

Dr. Shell's three-person practice, for which Dr. Hippie works, covers a HISA-covered area in Ohio—Thistledown–as well as West Virginia, where HISA is not in effect.

Drs. Shell and Hippie are charged with violating Rule 3214 (a), which reads:

Rule 3214. Other Anti-Doping Rule Violations Involving Banned Substances or Banned Methods

The following acts and omissions constitute Anti-Doping Rule Violations by the Covered Person(s) in question:

(a) Possession of a Banned Substance or a Banned Method, unless there is compelling justification for such Possession.

Mollica said that there is no violation of the rules for veterinarians possessing the substances to treat non-covered horses on farms or in other situations. “Both Dr. Shell and Hippie will show unequivocally that they were using the medication for the health and safety of non-covered horses. There's not one allegation of any banned substance being used on a covered horse.”

Earlier in September, Shell testified in person before a HIWU-related arbitration panel on behalf of trainer Dennis VanMeter, whose horse, Templement, had tested positive for isoxsuprine and phenylbutazone. VanMeter was facing a possible two-year ban as a result of the isoxsuprine positive alone.

At the hearing, it was established that Templement had been placed into one of trainer John Brown's stalls at Thistledown previously occupied by a pony routinely administered Isoxsuprine.

In the ruling, it notes that Shell “credibly testified that he and veterinarians in his practice had prescribed isoxsuprine to Mr. John Brown's pony Bucky for the last five years for a condition with its feet that would make it lame without medication.”

The arbitrator found the positive a likely instance of environmental contamination, and that VanMeter bore “no fault or negligence” for the isoxsuprine positive.

That hearing was on Sept. 12, a little over two weeks before Shell and his associate, Hippie, were allegedly found in possession of isoxsuprine and other banned substances, including bisphosphonates.

Additional reporting by Dan Ross. 

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HIWU Issues Suspensions For Bisphosphonates Possession

Two veterinarians have been provisionally suspended by the Horseracing Integrity and Welfare Unit (HIWU) for possession of bisphosphonates, the controversial drug for treatment of bone degeneration issues that has long bedeviled horse racing regulators due to its ability to stay in the system for years, and it's propensity to potentially weaken bones if misused.

It is understood these are the first such actions HIWU has taken for possession of bisphosphonates. No post-race or out-of-competition samples have as yet returned positive for bisphosphonates, according to the HIWU rulings web-page.

HIWU is the drug enforcement arm of the Horseracing Integrity and Safety Act (HISA).

In an action dated Sept. 28, the two veterinarians, Scott Shell and Barbara Hippie, have been accused of violating HISA Rule 3214(a), possession of banned substances. Formal hearings on the accusations are pending.

Aside from bisphosphonates, Shell is accused of possessing two other banned substances. One is Gamma Aminobutyric Acid (GABA), an amino acid that can be used as a calming agent. The other is the vasodilator Isoxsuprine, which can be used to treat laminitis and navicular disease.

Hippie is also accused of possessing Sarapin, a pitcher plant extract that can be used in pain relief, Isoxsuprine, and Levothyroxine, a thyroid treatment. All three are banned at all times under HISA.

The TDN emailed both Shell and Hippie Friday afternoon for comment. The story will be updated as necessary. An online search suggests the veterinarians are Ohio-based.

The TDN also contacted HIWU for further details of the complaint. Spokesperson Alexa Ravit wrote in response that the organization is unable to provide any further information regarding the alleged violations beyond what is listed on the website.

Ravit confirmed, however, that the violations were the result of each individual being in possession of the listed banned substances on Sept. 28. “Possession charges may result from searches of locations such as barns, offices, and veterinary trucks,” she wrote.

With brand names like Tildren and Osphos, bisphosphonates are used in older horses to tackle issues like navicular disease. They have also historically been used off-label to treat issues like sore shins in younger horses.

A problematic feature of bisphosphonates is that they can remain in a horse's system for many years after administration, making this a potentially tricky drug to track as horses pass through multiple hands.

Further complicating matters is how a horse administered a bisphosphonate won't necessarily test positive for the drug consistently over time.

Considering the severity of the sanctions for a banned substance positive finding, the slippery issue of bisphosphonates has made many industry stakeholders jittery.

Under HISA's rules, any “Covered Horse” proven to have been administered bisphosphonates will be subject to lifetime ineligibility, and the responsible individual could incur an anti-doping violation sanction.

Prior to HISA's anti-doping and medication control program (ADMC) going into effect earlier this year, HIWU chief of science, Mary Scollay, warned stakeholders to be vigilant about purchasing horses from aboard especially.

“As a condition of sale, I would have the seller attest that the horse has never been treated [with a bisphosphonate] so you have got the ability to turn that horse back and get your money back,” Scollay told an assembled crowd of stakeholders at Santa Anita in March. “It's a civil legal situation, but I think there are ways to protect yourself if needs be.”

Horses already in the racing pipeline may have been administered bisphosphonates in the past without their current connections' knowledge. With that in mind, one stakeholder asked Scollay if HISA's investigative body has the authority to go back over the horse's full medical history, in the event of a positive bisphosphonate test.

Though a young racehorse remains beyond HISA's legal purview until the time of its first official workout, HISA does have subpoena authority, explained Scollay. Ultimately though, as the HISA law is written, the burden of responsibility, she stressed, is placed on the trainer and owners' shoulders.

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Horse Sales And HISA, The Overlap

With the Horseracing Integrity and Safety Integrity Act's (HISA) anti-doping and medication control program set for launch Monday–pending approval by the Federal Trade Commission (FTC)–the inevitable focus will be on the spider web of post-race and out-of-competition testing set to blanket most of the nation.

But with it has come this other question: What do buyers now need to be aware of when purchasing a horse at the sales or privately?

The question has gained added currency since a recent the Southern California horsemen by representatives from the Horseracing Integrity & Welfare Unit (HIWU), the arm of HISA charged with rolling-out and managing its anti-doping and medication control (ADMC) program.

At that presentation, Mary Scollay, HIWU's chief of science, explained that under the new medication regime, bisphosophonates–a controversial group of drugs used in older horses to tackle issues like navicular disease but also used in younger horses to treat things like sore shins–will be banned from administration in what HISA terms “covered horses.”

(It should be noted that a Thoroughbred becomes a “covered horse” only when it completes its first officially timed and published workout)

“My last two weeks has pretty much been a deep dive into bisphosphonates and how to navigate this stuff,” said Joe Miller, a racing manager and bloodstock advisor, who leans heavily on Europe when scouting for new talent destined for the U.S.

“I actually skipped going to the OBS March sale because I'm so focused on how we're going to be moving forward in navigating these purchases,” Miller added.

For all sorts of reasons, bisphosphonates pose a slippery set of problems for regulators and horsemen alike. Once administered, they can stay in a horse's system for years. Horses given a bisphosphonate won't necessarily test positive for the drug consistently over time either, with a positive finding more likely during periods of bone remodeling, which would release the drug into the horse's system.

Punitive consequences for a positive bisphosphonate finding can be steep. A trainer faces a possible two-year suspension for a first-time bisphosphonate violation, while the horse could be subject to lifetime ineligibility from competition.

Joe Miller | Tattersalls

HIWU published a notice to the industry on March 10 regarding the use of bisphosphonates under the ADMC program, explaining how only proven administration of a bisphosphonate to a covered horse after the March 27th implementation date would be deemed an actionable violation.      Furthermore, HIWU explained that it would not pursue disciplinary action for a positive bisphosphonate finding against a covered horse and its connections, provided those connections can share with HIWU documentation–such as medical records or a positive test result–proving administration or presence of bisphosphonates prior to the ADMC program implementation date.

“In accordance with HISA's requirements for Covered Horses, all medical records, including any relevant test results, must be uploaded to the HISA portal. Additionally, due to the variability of bisphosphonate detection through laboratory analysis, all bisphosphonate findings detected under the ADMC Program will undergo thorough review regardless of the alleged timing of administration,” the notice added.

This still leaves some worrying holes for trainers and owners to potentially fall through.

A fear among buyers is that because of the longevity with which bisphosphonates can stay in the system, a recently purchased horse administered bisphosphonates prior to the ADMC launch date–and unbeknownst to the new connections–could still land them in regulatory hot water.

Furthermore, buyers like Miller are concerned about purchasing horses from international jurisdictions where bisphosphonates are still permitted.

“Since private sales are subject to individual contracts, it is up to the buyer and seller to formalize provisions for bisphosphonates testing and conditions of sale to protect all parties,” wrote Scollay, in response to a list of questions.

Miller hasn't made any international purchases since last October, he said, but he expects that to change in the next few weeks. When Miller does once again plunder foreign shores, “we can definitely do a blood screen for Osphos and Tildren,” he said, singling out two of the more commonly-used bisphosphonates. “I'm hoping we can do a urine screening as well.”

Indeed, urine samples are deemed more accurate than blood screens at detecting bisphosphonates administered longer in advance due to typically higher concentrations in urine of most substances than in the blood.

Though HIWU has stated it will conduct a thorough review in the event of a bisphosphonate positive, “If you come up with a trace amount of bisphosphonate in a post-race urine sample, how is that going to be dealt with?” asked Miller. “Is a horse going to be able to compete while the review is being conducted?”

According to HIWU spokesperson, Alexa Ravit, “HIWU will not just automatically issue a suspension for a Covered Horse or Covered Person upon receiving a positive finding for bisphosphonates.”

Fasig-Tipton is one of the major U.S. sales companies to have taken steps in recent years to limit drug use in the horses that pass through their rings, including offering bisphosphonate testing as a condition of sale for horses younger than four.

If the sale horse tests positive for bisphosphonates, a buyer has the right, within 24 hours of notification, to rescind the sale. In Fasig-Tipton's case, a bisphosphonates test costs $500.

“As with all these drug tests that have come along, it's usually because there has been a shift in the market,” said Bayne Welker, executive vice president of Fasig-Tipton. “That's usually what drives us to make these offerings.”

And as a result of HISA, “I'll probably take the limitations off of the racing age horses,” explained Welker, pointing to the condition of sale bisphosphonate test.

Indeed, Scollay stressed how “buyers should consult sales companies, as applicable, to verify the bisphosphonates testing available as well as the conditions of sale should a purchased horse test positive for bisphosphonates.”

Which leads to concerns over the use of other potentially problematic drugs, especially in horses-in-training purchases.

Major sales companies have moved in recent years to restrict the use in sales horses of non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids and bronchodilators, including Clenbuterol. Welker explained that HISA's new ADMC program won't change what condition of sale tests Fasig-Tipton offers for these particular substances.

Perhaps the biggest concern, explained Scollay, would be if the horse has been administered a banned substance that may linger in the horse for an extended period and show up in testing conducted under HISA, with anabolic steroids singled out for concern alongside bisphosphonates.

Scollay recommends that both buyers and sellers refer to HIWU's “Banned List,” which are the substances not permitted to be in a horse at any time once it falls under HISA's jurisdiction.

According to Miller, none of the drugs listed on HIWU's banned substances list cause him particular concern. “I only buy horses off people that we trust,” he said.

Furthermore, Miller said he will continue his current practice of performing a full blood screening of a horse pre-purchase.

Dr. Mary Scollay | The Jockey Club

“We typically test for steroids, any non-steroidal anti-inflammatories,” said Miller. “We just want to make sure when we do a soundness exam on a horse, we want to make sure they haven't been given anything.”

In regards private testing, however, there is an important distinction for stakeholders moving forward.

HIWU has contracted six labs around the country to conduct its testing program:

The Ohio Department of Agriculture's Analytical Toxicology Laboratory; the Animal Forensic Toxicology Laboratory at the University of Illinois-Chicago; Industrial Laboratories in Denver, Colo.; Kenneth L. Maddy Equine Analytical Chemistry Laboratory at the University of California-Davis; Pennsylvania Department of Agriculture's Pennsylvania Equine Toxicology and Research Laboratory; and University of Kentucky Equine Analytical Chemistry Laboratory.

Trainers and owners can ask HIWU to conduct clearance testing on a horse–for a fee–provided there is a reported administration history of a particular substance. Clearance testing though HIWU will be conducted at these six labs.

But these same HIWU-affiliated labs are prohibited by contract from testing any covered racehorses from private clients, explained Jeff Blea, California Horse Racing Board equine medical director.

And does Blea have any broader advice for industry stakeholders looking to close a sale after Monday?

“Any purchase of a horse as a buyer, you should have a conversation with your veterinarian as to what your concerns are and what your risk tolerance is relative to drug testing as a condition of sale,” Blea replied.

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HISA Issues Notice On Use Of Bisphosphonates

Edited Press Release

In advance of the anticipated effective date of HISA's Anti-Doping and Medication Control (ADMC) Program March 27, the Horseracing Integrity & Welfare Unit (HIWU) calls the Thoroughbred industry's attention to regulations regarding the presence and use of bisphosphonates in covered horses.

Bisphosphonates are a class of medication prescribed for managing clinical signs associated with navicular syndrome in horses 4-years-old or above. They also have a history of extra-label use in younger horses. Bisphosphonates may be detected in samples from treated horses for months to years after administration.

The ADMC Program regulations categorize bisphosphonates as a Banned Substance, meaning that they are prohibited from being administered to, or present in, covered horses at any time. Covered horses that test positive for bisphosphonates under the ADMC Program are subject to lifetime ineligibility, and associated covered persons may incur an Anti-Doping Rule Violation.

Given the prolonged detection period for bisphosphonates and the fact that their use is permitted in other racing jurisdictions internationally:

HIWU will not pursue disciplinary action against covered horses or their associated covered person(s) for the presence of bisphosphonates if the covered person(s) can provide documentation (e.g., medical records or a positive test result) to HIWU of the administration or presence of bisphosphonates prior to the implementation date of the ADMC Program. In accordance with HISA's requirements for covered horses, all medical records, including any relevant test results, must be uploaded to the HISA portal. Additionally, due to the variability of bisphosphonate detection through laboratory analysis, all bisphosphonate findings detected under the ADMC Program will undergo thorough review regardless of the alleged timing of administration.

If owners or horsemen have concerns that their horses may have been administered bisphosphonates prior to March 27, including prior to a sale at public auction domestically or internationally, HISA and HIWU advise them to consider bisphosphonate screenings for these horses before the ADMC Program takes effect.

The Horseracing Integrity and Safety Act does not enable HISA's ADMC Program to be enforced retroactively for actions occurring prior to its implementation. The detection of administrations from prior to March 27 that violate respective state rules in effect during that time period will be referred to the relevant state regulatory authorities.

While bisphosphonates continue to be permitted in Thoroughbred racehorses in international jurisdictions, any covered horse proven to have been administered bisphosphonates after the March 27 implementation date will be subject to lifetime ineligibility, and associated covered persons may incur an Anti-Doping Rule Violation.

For questions about the use of bisphosphonates and other substances on the ADMC Prohibited List, stakeholders are encouraged to visit here and reach out to HIWU Chief of Science Dr. Mary Scollay at mscollay@hiwu.org.

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