Is Your Steed Sleepy? Anemia May Be To Blame

Anemia in humans often manifests as tiredness or weakness. The condition is caused by a lack of enough healthy red blood cells to carry enough oxygen to their tissues, and often leads to compromised metabolic and immune system functions. Though the causes can vary, some types of anemia can be prevented by eating a healthy, varied diet that includes a plethora of vitamins and minerals. 

Iron-deficiency anemia in horses is rare, but it does happen. Most horses get sufficient amounts of iron in their diet from hay, pasture, and commercial feeds. An average horse needs 400 to 500 mg of iron per 500 kg of body weight, reports Dr. Gulsah Kaya Karasu of AGG Equine Nutrition Consulting in EQUUS magazine

Horses may end up with anemia because of blood loss (causes may include an injury, cancer, or ulcers), reduced blood cell production, or blood cell destruction. 

Some infections, like equine infectious anemia, can lead to red blood cell destruction, as can a heavy worm burden, particularly large strongyles. Chronic kidney disease, cancer, and a few other disorders can prevent a horse from making adequate red blood cells.

An anemic horse will have pale mucous membranes and an increased heart rate, in addition to being sluggish. Adding additional iron to the affected horse's diet isn't recommended as excessive iron can lead to depression, diarrhea, and compromised immune function. It can also interfere with the body's ability to absorb other minerals and increase the risk of a horse becoming insulin resistant. 

Iron-related anemia is rare in horses, so a thorough investigation by a vet is recommended for diagnosis.

Read more at EQUUS. 

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Equine Cancer: Difficult To Detect, Expensive To Treat

Diagnosing systemic cancer in horses can be difficult. Clinical signs are often vague and include things like weight loss, fever, disinterest and exercise intolerance – all issues that could be indicative of another issue.

If common causes like disease, parasites, digestive disorders, and other common ailments have been ruled out, Dr. Liya Wang and other researchers from the Swedish University of Agricultural Sciences suggest that systemic cancers should be considered. The research team also notes that cancer should be suspected if a horse doesn't respond well to traditional therapies, or if he begins to lose organ function.

Bloodwork run on horses that have cancer often comes back as nonspecific, but it may show that the horse is anemic and has elevated globulin concentrations and increased neutrophils. Though additional diagnostic work in search of conclusive results is available, it's often quite invasive and extensive.
The inability to find a reliable cancer biomarker often delays diagnosis, and results in ineffective treatments and poor chances of survival.

Wang and her team crafted a study to see if thymidine kinase 1 (TK1) could be used as a cancer biomarker in horses with lymphoma.

Serum TK1 is used as a cancer biomarker in humans. TK1 is important for DNA replication and cell proliferation. In healthy cells, TK1 degrades rapidly after cell division. In cancer cells, TK1 production is increased and leaks into the blood.

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The researchers measured serum TK1 in seven horses with lymphoma, five horses suspected to have lymphoma, 107 horses with diseases that weren't tumor related, and 42 horses with no sign of disease. Serum TK1 was significantly higher in horses with lymphoma and suspected lymphoma. Serum TK1 was also elevated in the diseased horses without lymphoma.

The team concludes that these findings indicate that serum TK1 could be used as a cancer biomarker in horses.

Read the study here.

Read more at HorseTalk.

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