July, 2023 | Horse Racing Free Tips

Study Confirms Hair Use For Long-Term Detection Of Bisphosphonates

A new study, called for in 2019 by the Grayson-Jockey Club Research Foundation, was published on the use of hair as a matrix for the long-term detection of bisphosphonates in horses, the organization said in a release Thursday.

“Over the past few years, bisphosphonate use has become a concern with regard to the welfare of Thoroughbred racehorses,” said Jamie Haydon, president of Grayson. “We are very thankful for the generous support by Vinnie and Teresa Viola's St. Elias Stables and their ability to recognize the importance of this research in promoting equine safety and welfare.”

The new study found that hair testing can be used to consistently detect bisphosphonates for up to six months after administration.

“Bisphosphonates are labeled for horses 4 years and older to manage navicular symptoms,” said Dr. Johnny Smith, A. Gary Lavin Research Chair of Grayson. “Unfortunately, people were using them in young horses, which is detrimental because bisphosphonates inhibit bone resorption, can stay in a horse's system for years, and can have long-term effects on bone.”

Previously published studies, including one conducted by the same group and funded under the same special call, demonstrated that in some cases bisphosphonates can be detected in blood and urine for extended periods of time, but detection using these matrices can be unpredictable and less consistent.

“Our study from 2020 showed that clodronate and tiludronate reside in the bone for extended periods,” said the study's principal investigator, Dr. Heather K. Knych, who is with the K.L. Maddy Equine Analytical Chemistry Lab's Pharmacology section and the Department of Molecular Biosciences, at the School of Veterinary Medicine, University of California, Davis. “This can lead to lasting pharmacologic effects and increase the risks of injury to racehorses. Being able to detect bisphosphonates long term in hair benefits the athletes and increases the integrity of the sport.”

Bisphosphonates are considered a banned substance for covered horses under the Horseracing Integrity and Safety Authority's Anti-Doping and Medication Control program. A covered horse that tests positive is subject to lifetime ineligibility.

Click here to read the study.

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Gun Runner To Stand For $65K On Southern Hemisphere Time; Golden Slipper Bonus Offer

Three Chimneys Farm's multiple-leading sire Gun Runner (Candy Ride {Arg}) will stand to Southern Hemisphere time and they are offering a AU$500,000 bonus to any progeny that wins the G1 Golden Slipper S., Doug Cauthen, the vice chairman of Three Chimneys Farm, told TTR AusNZ.

The farm's stud fee of $65,000 (AU$98,000) is slightly less than the $75,000 (AU$110,000) he commanded last year on Southern Hemisphere covers. They are hoping to attract anywhere between 20 and 40 Southern Hemisphere mares this spring.

“The goal is to make him appealing,” Cauthen said. “He's consistently bred to Southern Hemisphere time, but last year and this year, we've really tried to open him up more. He's bred a solid book in the past without it being a big book, because we're not looking for a big book. We're looking for quality.”

The American Horse of the Year produced six individual Grade I winners from his first book of 127 foals en route to Champion Northern American first-crop sire honors. He was also the leading sire of 3-year-olds in 2022, which included Echo Zulu, Gunite, Cyberknife and Early Voting.

“He's been spectacular, and everyone here is feeling blessed to have him at Three Chimneys,” Cauthen said. “But we think the potential to continue this, and build on it, is right there in front of him. Who he's as good as, we'll find out in five or 10 years' time, but he's certainly been exceptional so far.”

The AU$500,000 bonus to any progeny of Gun Runner that wins the Golden Slipper S. is also on the table.

“Like the Kentucky Derby or any of these great races, just getting runners in the field is the hardest part,” Cauthen said. “Time will tell but we think it's a legitimate possibility for Gun Runner to get horses into the Slipper, therefore we should offer a legitimate bonus.”

Emirates Park bred its Golden Slipper winner Estijaab (Aus) (Snitzel {Aus}) to Gun Runner on SH time last year. She's currently heading back Down Under safely in foal to the stallion.

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Authentic Full-Brother Bushin Switches To Dirt in Japan

In this continuing series, we take a look ahead at US-bred and/or conceived runners entered for the upcoming weekend at the tracks on the Japan Racing Association circuit, with a focus on pedigree and/or performance in the sales ring. Here are the horses of interest for this weekend running at Chukyo and Hakodate Racecourses:

Saturday, July 8, 2023
3rd-CKO, ¥10,480,000 ($72k), Maiden, 3yo, 1800m
CUPIDON (c, 3, American Pharoah–Chocolate Pop, by Cuvee), a half-brother to the versatile MGSW & GISP Airoforce (Colonel John), finished midfield in two tries over this distance at Hanshin last year and made his seasonal return with a runner-up effort in a 1400-meter allowance at Urawa on the NAR circuit June 1. A $300,000 purchase by Kokhi Maeda out of the 2021 Keeneland September sale, the gray would become a 31st Japanese winner for his Triple Crown-winning sire. Springhouse Farm acquired the multiple stakes-placed Chocolate Pop in foal to Bernardini for $460,000 at Keeneland January in 2017. B-Camas Park Stud & Lynch Bages Ltd (KY)

Sunday, July 9, 2023
1st-HAK, ¥10,480,000 ($72k), Maiden, 2yo, 1000m
BUSHIN (c, 2, Into Mischief–Flawless, by Mr. Greeley), the full-brother to Horse of the Year Authentic, switches to a minimum trip on the dirt for this third go, having finished a debut third at a mile on the grass June 3 and second over six furlongs at this venue June 24 (see below, SC 8). Flawless was offered with this colt in utero at the 2020 Fasig-Tipton November Sale days after Authentic's championships-clinching victory in the GI Breeders' Cup Classic, but was retained by Peter Blum after bidding reached $4.1 million. Bushin fetched $800,000 at Keeneland September last fall and the mare has since foaled a pair of Into Mischief fillies for Blum. B-Peter E Blum Thoroughbreds LLC (KY)

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Study Confirms Hair Testing For Long-Term Detection Of Bisphosphonates

A new study was published on the use of hair as a matrix for the long-term detection of bisphosphonates in horses. The study was in response to a special call for bisphosphonate research by Grayson-Jockey Club Research Foundation in 2019.

The new study found that hair testing can be used to consistently detect bisphosphonates for up to six months after administration. Previously published studies, including one conducted by the same group and funded under the same special call, demonstrated that in some cases bisphosphonates can be detected in blood and urine for extended periods of time, but detection using these matrices can be unpredictable and less consistent.

The study was conducted by Knych; D.S. McKemie, Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis; S. Yim, K.L. Maddy Equine Analytical Pharmacology Lab, School of Veterinary Medicine, University of California, Davis; S.D. Stanley, University of Kentucky College of Agriculture, MH Gluck Equine Research Center, Lexington, Kentucky; and R.M. Arthur, School of Veterinary Medicine, University of California, Davis. Read the study here: doi.org/10.1016/j.jchromb.2023.123789.

Grayson-Jockey Club Research Foundation is traditionally the nation's leading source of private funding for equine medical research that benefits all breeds of horses. Since 1940, the foundation has provided more than $40 million to fund more than 426 projects at 45 universities in North America and overseas. Additional information about the foundation is available at grayson-jockeyclub.org.

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