Month: February 2021

Penn Vet Develops New Gene Doping Test

A new test developed by researchers at the University of Pennsylvania School of Veterinary Medicine (Penn Vet) can detect the presence of gene doping in equines. Partly supported by the Pennsylvania Horse Breeders Association (PHBA) and the Pennsylvania State Horse Racing Commission, the findings, which systemically detect the local administration of illicit, gene doping therapies, are a significant breakthrough. Unlike other small molecule pharmaceuticals, gene doping agents trigger cells to produce performance-enhancing proteins, which often are virtually indistinguishable from naturally occurring proteins within the body, making it more difficult to determine whether or not an animal has had gene therapy.

The team of Penn Vet researchers has created and validated a quantitative real-time polymerase chain reaction (PCR) test–a term that has become common vernacular due to COVID-19 tests-which is able to detect the presence of a gene doping agent in plasma and synovial fluid after its intra-articular administration in horses.

“For the first time, we have demonstrated that a PCR test performed on a blood sample can detect the local administration of a gene therapy into the joint of a horse,” said Mary Robinson, PhD, VMD, DACVCP, assistant professor of Veterinary Pharmacology and director of the Equine Pharmacology Laboratory at Penn Vet's New Bolton Center. “While this test is currently limited in that it can only detect a specific gene therapy, it provides proof of concept that a gene therapy administered into the joint can be detected in a blood sample in a manner that is quick, convenient, and consistent with our long-term goal of deploying pre-race testing someday in the future.”

The researchers at Penn Vet were able to detect the gene doping agent in equine joint fluid after it was administered intra-articularly and in blood for up to 28 days, making it useful for both pre-race and out-of-competition testing.

More work is being done by Penn Vet with the goal of someday creating “biological passports” and screening tests that would successfully identify multiple gene doping agents for even longer periods of time. Researchers believe biomarkers could also be key in detecting gene doping as well as predicting injuries before they happen.

“We still have a lot of work to do to better understand the nature of biomarkers and how to fully harness their capabilities, but the science for detecting gene doping is getting there and much more quickly than any of us could have anticipated when we started this research,” said Robinson. “Ideas that once may have seemed unattainable–like a hand-held, stall-side testing device–are now coming into sight as real and tangible possibilities. We just need continued support to help get us there.”

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Fountain Of Youth: Holy Bull Winner Greatest Honour Faces Breeders’ Cup Juvenile Turf Victor Fire At Will

Courtlandt Farms' Greatest Honour, already a prime prospect on the strength of his dominating victory in the Jan. 30 Holy Bull (G3), will take a significant step along the Road to the Triple Crown in Saturday's $300,000 Fasig-Tipton Fountain of Youth (G2) at Gulfstream Park.

The Shug McGaughey-trained colt will have the opportunity to virtually clinch a spot in this year's Kentucky Derby (G1) field with a win in the Fountain of Youth, a 50-20-10-5 qualifying points race, as well as the important prep for the $750,000 Curlin Florida Derby (G1) presented by Hill 'n Dale Farm at Xalapa March 27 at Gulfstream.

The Fountain of Youth, a tradition-rich 1 1/16-mile race for 3-year-olds, will anchor Saturday's blockbuster 14-race program with nine stakes, including the $200,000 Davona Dale (G2), featuring the 2021 debut of Breeders' Cup Juvenile Fillies (G1) heroine and Eclipse champion Vequist.

Greatest Honour, who broke his maiden in his fourth career start Dec. 26 at Gulfstream, rallied from seventh in a field of nine to draw away by 5 ¾ lengths under Jose Ortiz in the 1 1/16-mile Holy Bull. The son of Tapit has shown McGaughey all the signs that he has moved forward in his training at Payson Park in Indiantown, FL since his winning stakes debut.

“He had a really good work up there Sunday morning. I was pleased with the work and was very pleased with the way he looked and the way he was acting,” said McGaughey, who is hoping Greatest Honour, the 9-5 favorite, will follow the example of Orb, whom he saddled for victories in the Fountain of Youth, Florida Derby and Kentucky Derby (G1) in 2013.

Courtlandt Farms' homebred colt launched his career with a pair of strong closing third-place finishes in maiden special weight sprints at Saratoga and Belmont before losing a photo finish in his first trip around two turns at Aqueduct and completing his juvenile season with his 1 1/16-mile maiden breaker at Gulfstream.

McGaughey would gladly accept a set-up in the Fountain of Youth like the one he had in the Holy Bull, in which he rated well behind a contested early pace before producing a strong stretch rally.

“We'd like to see some speed ahead of him. When you have a horse that comes from behind, if you have some pace in front of you, it helps you,” said McGaughey, who saddled Code of Honor for a win in the 2019 Fountain of Youth. “But I'm not going to be overly worried if there isn't.”

Jose Ortiz has the return mount on Greatest Honour, who drew Post No. 8 in a field of 10.

Drain the Clock, an impressive winner of the seven-furlong Swale (G3) on the Holy Bull undercard, is expected to be an imposing pace factor from his rail post position Saturday in his stretch-out around two turns in the Fountain of Youth. He's 5-1 in the morning line.

The son of Maclean's Music was won four of five lifetime starts, his only loss coming when he lost his rider due to a broken iron during the running of the Nov. 30 Jeanne Laffite Stakes at Delta Downs. He entered the Delta stakes off a six-length debut victory at Gulfstream Park and an optional claiming allowance at Gulfstream Park West. The Joseph trainee bounced back from his ill-fated trip to Louisiana with a 7 ½-length win in the Jan. 2 Limehouse and a 6 ¼-length triumph in the Swale during the 2020-2021 Championship Meet.

“He's a very talented horse. He showed that before he even ran. The second or third breeze he showed he had talent,” Joseph said. “The only blemish on his record was at Delta, and that wasn't his fault. Last time, he couldn't have won any easier than he did. He's won all his races in a good fashion. Hopefully, he can keep it going.”

Owned by Slam Dunk Racing, Madaket Racing Stables LLC, Wonder Stables and Michael Nentwig, Drain the Clock will be ridden by Edgard Zayas.

Three Diamonds Farm's Fire At Will (7-2), who captured the Nov. 6 Breeders' Cup Juvenile Turf (G2) at Keeneland last time out, is set to return to dirt in the Fountain of Youth.

“It's a tough task, whether he's a dirt horse or a turf horse, but he's earned the chance,” trainer Michael Maker said.

After finishing sixth on turf in his Aug. 8 debut at Saratoga, Fire At Will broke his maiden in the Sept. 2 With Anticipation Stakes over a sealed sloppy main track at the Spa. The son of Declaration of War went back to turf to capture the Oct. 3 Pilgrim (G2) at Belmont by two lengths and the Breeders' Cup Juvenile Turf by three lengths.

Kendrick Carmouche, who guided Fire At Will to victory in the Pilgrim, returns to the saddle.

Tarantino, who is owned by SF Racing LLC, Starlight Racing, Madaket Stables LLC, Stonestreet Stables LLC, Golconda Stables, Siena Stables LLC and Robert Masterson, made a respectable transition from turf to dirt in the Holy Bull, in which he pressed a solid early pace before finishing second behind Greatest Honour and 3 ¾ lengths ahead of third-place finisher Prime Factor.

The 3-year-old son of Pioneerof the Nile, who was a nose away from being undefeated on turf in his first three starts. He won his debut and lost a stakes by a nose in Southern California with Hall of Fame trainer Bob Baffert before capturing a Dec. 11 optional claiming allowance on turf at Gulfstream in his first start for trainer Rodolphe Brisset and finishing second in the Holy Bull on dirt.

“We're hoping he can be a couple lengths better this time,” said Brisset, who expects Tarantino (8-1) to move forward from his dirt debut.

Tyler Gaffalione is scheduled to ride Tarantino for the first time Saturday.

WinStar Farm LLC and CHC Inc.'s Prime Factor (5-1), who was favored in the Holy Bull, will be seeking to rebound in the Fountain of Youth. The son of Quality Rod debuted with a dazzling 8 ¾-length victory at Gulfstream Dec. 12 before taking a giant step up in the Holy Bull, in which he stalked the pace and raced evenly in the stretch to finish a distant third.

“We're hoping he shows improvement after having only two starts. He came out of that race good. He came back with two really good breezes,” trainer Todd Pletcher said. “We're just hoping it was a lack of experience and seasoning. He's trained like a good horse, so we'll see what he can do.”

Pletcher named Irad Ortiz Jr. to ride Prime Factor.

Magic Stable LLC's Papetu, who finished three-quarters of a length behind Prime Factor while checking in fourth in the Holy Bull, will also return in the Fountain of Youth.

“I think he made his move too soon,” trainer Antonio Sano said of his 15-1 shot. “He needs to relax early and make his run at the three-eighths [pole].”

Sano, who saddled Gunnevera for a victory in the 2017 Fountain of Youth, has named Junior Alvarado to ride Papetu.

Trainer Dale Romans, who saddled Promises Fulfilled for a Fountain of Youth score in 2018, will be represented Saturday by West Point Thoroughbreds and Peacock Stable's King's Ovation (15-1), who finished second behind Drain the Clock in the Swale.

OGMA Investments LLC and Off the Hook LLC's Jirafales, Teresa and David Palmer's Sososubtle (20-1), and David Bernsen LLC's Tiz Tact Toe (30-1) round out the field.

The post Fountain Of Youth: Holy Bull Winner Greatest Honour Faces Breeders’ Cup Juvenile Turf Victor Fire At Will appeared first on Horse Racing News | Paulick Report.

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Jackie’s Warrior, Former King of the Hill, Looks to Reclaim His Perch

In the world's current state of affairs, a lot can change in a few months' time. Racing is no different. One only has to go back to November to remember when Kirk and Judy Robison's Jackie's Warrior (Maclean's Music) was the undisputed leader of his age group. But an odds-on loss on the sport's biggest stage took the bloom off of his rose for some, and these days, despite being a multiple Grade I winner, one could argue he is a forgotten colt as the GI Kentucky Derby trail kicks into high gear.

But opportunity knocks this Saturday, in the twice-delayed GIII Southwest S. at Oaklawn, where the brilliant $95,000 Keeneland September grad will make his 3-year-old debut and get his long-awaited rematch with the rival who snatched away his Eclipse statuette with a conquest of the GI Breeders' Cup Juvenile, Essential Quality (Tapit).

“Steve [Asmussen]'s extremely happy with the horse, I personally love the draw, number four in a seven-horse field and you get the favorite down on the rail, so I think we're good to go,” Robison said Wednesday of the Southwest, which was originally supposed to run Feb. 15 but got pushed back two times due to inclement weather in Hot Springs. “Steve never considered another race. From 6-8 weeks ago, he was always on track for this race and I think when they announced Essential Quality was probably going there too, it scared a few people off, but that's where we wanted to go from day one. No excuses.”

After dominating a trio of historic 2-year-old stakes last summer and fall–the GII Saratoga Special S., GI Runhappy Hopeful S. and GI Champagne S.–Jackie's Warrior was regarded highly enough to be hammered down to 9-10 favoritism in the Juvenile, one of the shortest prices of the entire Breeders' Cup weekend. But the speedball was caught too close to a scorching pace of :22.58 and :45.31, and just faded late after making the lead in mid-stretch under Joel Rosario, ending up fourth, beaten 3 3/4 lengths by tripped-out closer Essential Quality.

The nature of that first defeat raised doubts about Jackie's Warrior's ability to see out two-turn races, considering his running style and sprint-leaning pedigree.

“I think there's always been some question about whether he could get a mile and a sixteenth against top-flight horses,” Robison said. “He was not able to do it that day, but I'm very confident he can get it done Saturday. It's a different circumstance, smaller field, and I think Rosario and Steve probably learned a lot from what happened in the Juvenile, so let's see what happens.”

As for potentially trying to throttle the horse's speed down to increase his staying chances, Robison said, “He really is freaky fast, and I remember Steve telling me a long time ago about horses, 'Never take away what they do well.' So if you have a horse who outbreaks the field, don't take that advantage away from the horse, let him go on. He's just a natural speed horse and I think that's what his style will be. The question is going to always be, how far can he take that kind of speed? We'll find out.”

And, if Jackie's Warrior doesn't continue on the Derby trail after Saturday, that will be just fine with Robison, a veteran of the game who deeply appreciates the prestige of big races beyond the Run for the Roses.

“If he turns into a multiple Grade I winner around one turn, that's not the end of the world,” he said with a laugh. “I don't get up in the morning dreaming about a Derby horse. People at cocktail parties only want to hear about the Derby, but most of us in the industry know with these Grade I sprints and one-turn mile races, how important they are. I'm not going to presume what Steve's going to do after this race, but having said that, I think he'll run extremely well.”

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