Kentucky, New York Move Toward Tougher Restrictions On Clenbuterol

Trainers in several states could soon contend with tougher restrictions on the administration of clenbuterol, a bronchodilator prescribed for respiratory issues which veterinarians say can be misused. At a Dec. 1 meeting of the Kentucky Equine Drug Research Council (EDRC), committee members passed a proposed rule change for the drug which would move administration time from 14 days pre-race to 21 days pre-race, with a requirement the horse be tested for the substance before being cleared to run.

Clenbuterol is a beta-2 agonist which is known as an effective solution for horses battling respiratory ailments — a particularly common problem in racetrack barns which often have poor ventilation. Like other beta-2 agonists, however, it can also decrease body fat and increase muscle mass, particularly by converting slow twitch muscle to fast twitch muscle when used repeatedly.

At a September meeting of the EDRC, Kentucky Horse Racing Commission equine medical director Dr. Bruce Howard revealed that nearly 100 percent of Kentucky-based horses from trainers currently under federal indictment showed signs of clenbuterol administration when they were hair tested. Howard has also seen instances of veterinarians prescribing the drug to every horse in the barn.

The measure to move back the drug's administration time was not without debate. Dr. Andy Roberts, member of the EDRC and longtime Standardbred veterinarian, raised concerns about the harness population's ability to treat horses for illness under a 21-day withdrawal.

“I don't want to diminish the concerns about clenbuterol, because I think it's not illegitimate to want to control its administration to legitimate therapeutic purposes, however I think the Standardbreds are taking it quite strongly in the shorts in this because our horses race every week,” said Roberts. “There's almost no opportunity to put horses on clenbuterol already. Several other states already recognize this and have shorter withdrawals on clenbuterol.”

Roberts asked Howard whether out-of-competition testing at Red Mile had detected any clenbuterol use thus far, and Howard said it had not.

“That's because you've taken the drug out of my hands on a therapeutic basis,” said Roberts, who also maintained that the repartitioning effect of clenbuterol on muscle lasts for 11 days. “Passing rules based on speculation that somebody else is doing something — and I say this specifically from a Standardbred point of view because these horses are in to go often enough that you have already severely limited my ability to use this drug properly. People would rather leave horses sick and end up with pleural pneumonia than treat them with clenbuterol. That means we are over-regulating it.”

The 21-day window is based on the limit of detection by drug testing laboratories tasked with finding clenbuterol in a horse's urine sample. Blood and urine tests would be used to clear a horse to race after clenbuterol administration. Hair samples would show clenbuterol administration for up to six to twelve months after administration, but are highly variable depending on hair growth rates.

All EDRC committee members except Roberts voted for the increased restriction.

The vote comes a day after commissioners in New York expressed an interest in restricting clenbuterol use there, too. The Daily Racing Form reported the New York State Gaming Commission voted to require veterinarians to seek permission from the equine medical director before administering the drug, and that horses receiving clenbuterol must pass drug tests showing it has cleared the system before being permitted to run. That is similar to rule language being considered in other Mid-Atlantic states. In Canada, clenbuterol administration was pushed out to 28 days pre-race earlier this year. The American Quarter Horse Association announced a zero tolerance policy on clenbuterol in 2014, which has subsequently been picked up by several states where Quarter Horse racing is a central part of the calendar.

Experts have raised concerns about the potential for clenbuterol abuse for years, but the drug has made more headlines this year, as influential trainers like Mark Casse have called it one of the “most abused drug in our industry.”

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21-Day Vet’s List Stint Recommended for Clenbuterol in KY

The Kentucky Equine Drug Research Council (EDRC), which serves as an advisory board to the Kentucky Horse Racing Commission (KHRC), advanced a Dec. 1 recommendation to that full board that would require any horse who receives clenbuterol to be restricted via the veterinarian’s list for 21 days and then test clear of that substance prior to being removed from the list and allowed to compete.

Kentucky’s current clenbuterol regulation requires a prescription that must be filed with the KHRC within 24 hours of dispensing the drug and a withdrawal time of 14 days, according to Bruce Howard, DVM, who serves as the equine medical director for the KHRC.

Howard explained prior to the vote that the switch would align Kentucky with a clenbuterol model rule enacted by the Racing Medication and Testing Consortium on Aug. 24.

Within the past year, a number of racing jurisdictions have tightened clenbuterol restrictions based on evidence showing the medication has been widely abused for its repartitioning effect that promotes lean muscle mass. Originally, clenbuterol was developed and is still prescribed as a potent bronchodilator that effectively treats respiratory issues.

On Jan. 1, the California Horse Racing Board enacted a clenbuterol rule that requires a prescription for appropriate usage plus a stint on the vet’s list until the drug clears. On May 1, the Canadian Pari-Mutuel Agency started banning clenbuterol 28 days out from race day at tracks country-wide. On Oct. 22, the Maryland Racing Commission advanced a rule proposal similar to California’s, and the New York State Gaming Commission did the same Nov. 30.

In addition, more restrictive “house rules” will be in effect at Gulfstream Park and Oaklawn Park during their race meets, and racing commissions in Pennsylvania, Delaware, New Jersey and Virginia are also expected to clamp down on clenbuterol abuse by changing or writing new regulations.

“The KHRC office has received concerns and comments from numerous trainers and owners who feel that clenbuterol is being misused,” Howard said. “They’re concerned that clenbuterol is being used for the anabolic-type [steroid] effect rather than the therapeutic effect prescribed. There have been instances where veterinary records show clenbuterol is being dispensed to numerous horses in a barn, and in some cases the entire stable.

“The KHRC staff would propose that horses being prescribed clenbuterol for medically therapeutic purposes be placed on the veterinarian’s list for 21 days, with blood and urine testing negative for clenbuterol required for being removed from the veterinarian’s list,” Howard continued.

The clenbuterol proposal was the only item on Tuesday’s EDRC agenda, and it drew little discussion among board members, who had already broached the subject during a September meeting.

However, Andy Roberts, DVM, who represents Standardbred interests on the EDRC, again voiced concerns he raised in September about the need to treat harness horses differently than Thoroughbreds when it comes to clenbuterol because of how frequently Standardbreds race.

“I don’t want to diminish the concerns about clenbuterol because I think that it’s not illegitimate to want to control its administration to legitimate therapeutic purposes,” Roberts said. “However, I think the Standardbreds are taking it really quite strongly in the shorts on this one, because our horses race almost every week. There’s almost no opportunity to put the horses on clenbuterol already.”

Roberts noted that several states have shorter withdrawal times for Standardbreds on clenbuterol, and he said that Kentucky’s current 14-day standard backed by out-of-competition (OOC) testing protocols should be enough to catch abusers. He added that recent OOC testing at The Red Mile did not result in any clenbuterol positives

“That’s because you’ve taken the drug out of my hands on a therapeutic basis,” Roberts added.

Howard disagreed that tightening clenbuterol further would be harmful to Standardbreds.

“If a horse is severely ill enough that you feel you need to prescribe this drug, we’re trying not to take this out of your hands for therapeutic purposes,” Howard said. “I think this is a compromise to try and get away from the anabolic effect but still leave it in the hands of the private veterinarians…. I think it’s the perception of this anabolic-type effect or repartitioning effect that is what’s got everyone up in arms. When trainers are looking for that type of effect, that’s where the misuse or abuse of this drug takes place.”

Roberts countered: “First of all, it’s not an anabolic effect. It’s a repartitioning effect. And I know that’s splitting hairs, but it is not the same. Second, that repartitioning effect [has been shown in published studies] to last 11 days. So [the repartitioning effect] is gone before the drug is gone.”

Roberts warned fellow EDRC members about the danger of recommending rules based largely upon speculation that wrongdoing is occurring, adding that he already believes Standardbred trainers are withholding legitimate clenbuterol administration out of fears of triggering a positive.

“People would rather leave horses sick and end up with pleuropneumonia than treat them with clenbuterol. That means we are over-regulating,” Roberts said.

The board briefly debated a suggestion to have different rules for each breed, but KHRC executive director Marc Guilfoil said that was not how the KHRC operates on issues like this one.

“No, this is an all-encompassing rule in Kentucky. One racing commission, [all] breeds. It would encompass the Standardbred horses the same as it would Thoroughbreds,” Guilfoil said.

The EDRC passed the measure by voice vote, with Roberts the lone dissenter.

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Study Shows Machines Can Detect Equine Pain From Daily Behavior

Machines may soon play a role in monitoring pain in horses admitted to veterinary clinics. Currently, it can be difficult to find an unbiased, quick way to determine if a horse is in pain. Drs. Nuray Kil, Katrin Ertelt and Ulrike Auer created a study that used an automated video tracker to detect and record daily equine activities. The end goal was to have the tracker create an algorithm that would be able to objectively assess pain and wellbeing of horses in a clinical setting. This ability would remove the guesswork of veterinarians and technicians determining if a horse was in pain.

Pain causes behavior changes in horses; understanding normal and pain-induced behaviors in horses is critical to properly evaluating pain levels. Though horses may work to mask pain in an unfamiliar surrounding like a clinic, even subtle variations become apparent when behavior is thoroughly analyzed.

Though there are multiple pain assessment scales available, they are all scored manually and can be skewed by multiple things, including inexperience and the amount of time spent viewing the horse.

To test their video tracker theory, researchers used 34 horses at the University of Veterinary Medicine in Vienna's teaching hospital. All the horses were housed in box stalls with water and were fed four times a day. The horses were recorded on an action camera and in time-lapse mode. The videos were then processed to look for an automated prediction of three body parts: the tail, nose and withers.

The technology was able to identify the horse's stance with an accuracy and sensitivity of more than 80 percent, meaning that it could more often than not detect when a horse was exhibiting pain behaviors. The research team concluded that this technology will improve the detection of equine pain and provide insight for equine behavioral research.

Read the study here.

Read more at HorseTalk.

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