IFHA Conference Concludes With Racing Administrators’ Session

The virtual International Conference of Horseracing Authorities, organized by the International Federation of Horseracing Authorities, came to a close on Wednesday with the release of its fourth and final session, where racing administrators around the world looked at how COVID-19 has impacted racing, the positives and negatives that have come out of the pandemic and what must be done to ensure racing thrives moving forward.

The IFHA Conference is typically held in-person in Paris, France the day after the Prix de l’Arc de Triomphe, but in light of the pandemic this year it was conducted as a series of videos released throughout the first part of October.

Rishi Persad moderated Wednesday’s fourth session, which was split into two panels comprising Victoria Carter (New Zealand Thoroughbred Racing), Winfried Engelbrecht-Bresges (Hong Kong Jockey Club and IFHA), Annamarie Phelps (British Horseracing Authority), Horacio Esposito (Organizacion Sudamericana de Fomento del Pura Sangre de Carrera), Drew Fleming (Breeders’ Cup) and IFHA Vice-Chairman Brian Kavanagh (Horse Racing Ireland).

The panelists discussed the ways in which racing has increased its focus on digitalization, the importance of strong relationships with government and how a likely decrease in foal crops will affect racing products.

Engelbrecht-Bresges and Fleming provided updates on the work being undertaken in the lead-up to two key international racedays: the Hong Kong International meeting in December and the Breeders’ Cup at Keeneland in three weeks’ time.

“We’ve had a very good response from major trainers around the world who would like to come, and we have special quarantine facilities now in place for grooms who will come,” Engelbrecht-Bresges said. “They’ll fly over two weeks earlier, then their horse will fly over and they’ll take it over. And we’re talking about introducing a special health protocol for jockeys that they maybe only have to do one week [of quarantine]. All our jockeys are tested four times a week for COVID and we want to introduce with overseas jockeys coming that they’re tested twice before they leave. When they arrive in Hong Kong they’ll go into a special dedicated Hong Kong Jockey Club facility to quarantine for a week.

“We have five or six top international jockeys who have committed to come for our international races if the [pandemic] circumstances don’t change.”

Fleming said Breeders’ Cup continues to work with the government and homeland security to secure the necessary paperwork to allow horsepeople to travel with their Breeders’ Cup runners. He also touched on some of the ways his team will be bringing the Breeders’ Cup to those watching at home.

“At the Breeders’ Cup this year we’re planning to have what’s called a back camera, which is a camera that’s on two cranes that swings across,” he said. “We’ll have more television cameras than we’ve ever had so we can get all angles of every horse as much as possible. We’re going to have a virtual reality camera in the walking ring. Some of that will be on television but a lot of that will be through the second screen, your mobile device.

“Someone told me, and it’s resonated with me for a long time, that the average person scrolls on their screen the height of the Empire State Building every single day. So you need to make sure what’s on the screen is really creative and innovative to really capture the audience’s attention.”

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Grade 1 Winner Nadal To Enter Stud In Japan

Nadal, a Grade 1 winner who went unbeaten in his four career starts, has been sold to enter stud at Shadai Stallion Station in Japan for the 2021 breeding season.

A fee will be announced at a later time for the 3-year-old son of Blame, who raced for owners George Bolton, Arthur Hoyeau, Barry Lipman, and Mark Mathiesen. Bob Baffert trained the colt, who was retired in May after suffering a condylar fracture in his left foreleg, requiring surgery.

Up until that point, Nadal was considered one of the favorites for this year's Triple Crown races, boasting an imposing record in California and Arkansas. He debuted in January of his 3-year-old season, winning a maiden special weight at Santa Anita Park by 3 3/4 lengths. He then made his stakes debut in the Grade 2 San Vicente Stakes, winning by a half-length.

The colt began pointing toward the Triple Crown in earnest with a shift to Oaklawn Park, where he took the G2 Rebel Stakes, then exploded to win a division of the G1 Arkansas Derby by three lengths.

Nadal retired with earnings of $1,053,000.

Bred in Kentucky by Sierra Farm, Nadal is out of the placed Pulpit mare Ascending Angel, putting him in the family of champion Pleasant Stage and Grade 1 winner Journey Home. He was a $700,000 purchase at the 2019 Fasig-Tipton Gulfstream Selected 2-Year-Olds In Training Sale.

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UC Davis Researchers Identify Genetic Variant For Fatal Condition In Thoroughbreds

Researchers at the UC Davis School of Veterinary Medicine have identified a genetic cause for the fatal condition equine familial isolated hypoparathyroidism (EFIH) in Thoroughbreds, marking the first genetic variant for hypoparathyroidism identified in any domestic animal species. Additionally, this is the first widely available genetic test for Thoroughbreds.

The study, led by Drs. Carrie Finno and Gary Magdesian,  which was reported in the journal PLoS GeneticsGenetic testing can now be performed at the UC Davis Veterinary Genetics Laboratory to identify horses with the variant and avoid mating carriers that could produce affected foals.

“For Thoroughbred owners and breeders, the loss of a foal has tremendous economic and emotional impacts,” says first author Victor Rivas, who conducted the project as part of his undergraduate training in  Finno's laboratory. “It is important to promote safe and strategic breeding habits by actively breeding horses genetically screened not only for EFIH, but for other diseases that may impact quality of life.”

Foals affected with EFIH suffer from low blood calcium concentrations, resulting in involuntary muscle contractions, muscle stiffness that leads to a stiff gait and can progress to an inability to stand, seizures, fevers, and an abnormally fast pulse. Parathyroid hormone is typically produced to increase calcium levels in the body, but in these foals, concentrations are low or “inappropriately” normal (i.e. they should be high due to the low calcium). Affected foals die or are euthanized due to poor prognosis. Necropsy results reveal underdeveloped or absent parathyroid glands.

Previously termed idiopathic hypocalcemia, EFIH has been observed in Thoroughbred foals up to 35 days of age. Disease onset and progression are likely determined by the amount of calcium in the diet early in life. This can vary based on dam milk calcium concentration and the amount of milk ingested.

The current study determined an autosomal recessive mode of inheritance and performed whole genome sequencing of two affected foals. A mutation in the rap guanine nucleotide exchange factor 5 (RAPGEF5) gene was present in two copies (homozygous) in both foals. The variant was further analyzed in a frog developmental model and demonstrated loss-of-function of the RAPGEF5 protein leading to aberrant development. Based on this data, the researchers hypothesize that RAPGEF5 may play a role in the derivation of the parathyroid gland during development.

The variant was not identified in individuals from 12 other breeds. The allele frequency for the RAPGEF5 variant in an expanded set of 82 randomly selected, unaffected Thoroughbreds was 0.018. An unbiased allele frequency study has not been performed, so the allele frequency in the larger Thoroughbred population is currently unknown.

“The next steps are to assess the allele frequency in a large population of randomly selected Thoroughbreds,” says Finno. “Additionally, we have discussed collaborating with Dr. Nathan Slovis at Hagyard Equine Medical Institute in Kentucky to test for the variant in cases of 'sudden death' in Thoroughbred foals.”

The clinical presentation of EFIH is similar to human familial hypoparathyroidism. Since the RAPGEF5 gene is highly conserved across species, it is a potential new candidate gene for primary hypoparathyroidism in humans.

“This type of research discovery requires a unique collaboration between clinicians, pathologists and basic researchers,” says Finno. “We were incredibly fortunate to have samples submitted from Drs.  Slovis, Daniella Leuthy (University of Pennsylvania) and Laura Javsicas (Rhinebeck Equine) and the expertise of Drs. Brian Caserto (VetPath services) and Andrew Miller (Cornell University). Additionally, the 'proof' of functional results of this genetic mutation would not have been possible without our collaborator from Yale University, Dr. Mustafa Khohka.”

Support for this study was provided by the UC Davis Center for Equine Health.

Read more here.

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Kameko To Miss Champions Day, Point To Breeders’ Cup

Classic winner Kameko (Kitten’s Joy) has been ruled out of Saturday’s G1 Queen Elizabeth II S. on British Champions Day at Ascot due to the likelihood of soft ground. The Qatar Racing colourbearer will instead head straight to the GI Breeders’ Cup Mile at Keeneland on Nov. 7.

“Given the ground at Ascot is going to be testing, Kameko will go straight to the Breeders’ Cup and will not run on Saturday,” said David Redvers, racing manager to Qatar Racing.

The Kentucky-bred Kameko, who won the G1 Vertem Futurity Trophy at two, won the G1 2000 Guineas on June 6 and, after a string of fourth-place finishes at the highest level this summer, returned to the winner’s enclosure in the Sept. 25 G2 Joel S. at Newmarket.

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