“She's had a setback and there will be no Guineas,” said Sangster of the filly, who is owned by his mother Lucy and the Ballylinch Partnership. “She was training great and had wintered well. She had grown and strengthened up and her work had been very good this spring. She was in very good shape and we were looking forward to it [the Guineas].

“I'm not sure on a timescale, we will just have to see how the rehab goes in the next few weeks and then we will have a better guide on it.”

Sangster also provided an update on Wathnan Racing's Per Contra (Ire) (Footstepsinthesand {GB}), who is two-for-three. After winning a Chepstow maiden last July, the colt made his first start in his new colours when running out a 4 3/4-length winner in a Ffos Las novice. He most recently ran fifth in the G3 Autumn S. in October.

“He's in good form, he's going galloping tomorrow and Monday and then we will begin plotting a bit of a route for him,” added Sangster.

“I think he will go up in trip this year. I don't think he will be a big stayer but he will go up to 10 furlongs anyway. I think he is off quite a nice mark, so we will see.”

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He said, “Opera Singer is a bit behind. She had a little setback, she had two weeks easy and might not make the English Guineas. She is likely to start in the Irish Guineas and we don't want to force her.”

Bred by the late Evie Stockwell, Opera Singer is a half-sister to the Group/Grade 1 winners Brave Anna and Hit It A Bomb, both by War Front. The daughter of Liscanna (Ire) (Sadler's Wells) won three of her five starts at two, culminating in her top-level triumph in Paris at the Arc meeting. Prior to that she had beaten Monday's G3 Park Express S. winner Brilliant (Ire) (Gleneagles {Ire}) in the G3 Newtown Anner Stud Irish EBF S. at the Curragh.

Her stable-mate Ylang Ylang (GB) (Frankel {GB}), winner of the G1 Fillies' Mile, has now replaced Opera Singer at the head of the betting for the 1,000 Guineas on Sunday, May 5.

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A two-time winner of that prize in 2021 and 2023, the 8-year-old gelding will face a restricted workout schedule for the next three to four weeks. Owned by Stanley Chan Ka Leung, the bay has won 10 Group 1s in Hong Kong.

“We found, the day before yesterday [Wednesday] in the morning, a little bit of filling and a little bit of heat [in his front left leg],” said trainer Francis Lui. “The vets did a check, a scan and an MRI–there's nothing serious, but they sent a report to England.

“It's very slight but, of course, for the safety side, we don't want to push him because the race is only three weeks' time. The vets said we can give him light trotting for three or four weeks and progressively we can check on him. The issue is just inside the pastern on his front left leg.”

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“Unfortunately, Yibir has met with a slight setback and will no longer be heading to the US for his next intended start,” Godolphin tweeted on Saturday morning.

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Ryan tweeted on Friday morning, “Unfortunately we have to say that Triple Time has met with a small setback which rules him out of the 2000 Guineas. It is a long season ahead and we will look forward to seeing him back in action.”

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“Unfortunately, Reach For The Moon sustained an injury during a routine canter on Warren Hill and he's currently at the vets being checked out,” John Gosden told the Racing Post. “He's out for the season but we can get him back for 2022.”

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Muir told Nick Luck's Daily Podcast, “He worked superb on Saturday, we went to Charlie Hills's and he worked stunning with a very good miler. I walked over to meet him coming back–he was bouncing –washed him down and what have you and all was fine, but that evening I just thought he was slightly wrong behind on his off hind.

“My vet came, his testicle was pulled right up so he thinks he might have rolled in his box and tweaked his groin. Any horse, they are my life, like my children, so I can't run him if he's not 100%.

“He'll be checked over again until we can find exactly what it is, but I told the owners I didn't even think I was going to confirm him which is gutting as he's as well as I could have him. He came off the gallops and I thought nothing could beat him.

Added Muir of other potential targets for his stable star, “There's loads more races–we're in the [G1] Juddmonte [International S. at York on Aug. 18] whatever happens if it's something very simple. We were going to give him a break at some stage as we're thinking of taking him round the world at the back end of the season, so maybe this might be the enforced break. We've got to do whatever is right with every horse we've got.”

Besides Love, seven other Group 1 winners–have stood their ground for the Ascot showpiece, including the 4-year-old filly Wonderful Tonight (Fr) (Le Havre {Fr}), as well as G1 Cazoo Derby hero Adayar (Ire) (Frankel {GB}) and Broome (Ire) (Australia {GB}), globetrotters Mishriff (Ire) (Make Believe {GB}) and Addeybb (Ire) (Pivotal {GB}), and Galileo full-brothers Mogul (GB) and Japan (GB).

“I talked to John after Mishriff worked on Saturday and John was very happy with him,” said Ted Voute, racing manager for Mishriff's owner Prince Faisal on the $20-million Saudi Cup and G1 Dubai Sheema Classic scorer. “It has very much been left up to John where he runs next and, having discussed it with the Prince, Ascot looks the likely target.

“We want to win a Group 1 in England with Mishriff and you can't win one unless you run in them. He has beaten some very good horses from around the world and now is the time to see what he can do against the big battalions from England and Ireland in particular.”

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“2000 Guineas runner up Master Of The Seas unfortunately had a setback after training on Saturday and will now be on the easy list for two to four weeks, meaning he will miss Royal Ascot,” Godolphin tweeted on Monday morning.

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“It’s a real shame, but this is what can happen with horses–he’s just wasn’t 100% sound this morning,” said Castle Down Stud’s Mark Weinfeld. “We’re absolutely gutted. It’s nothing too serious, but it’s just sod’s law.

“He’s in the G1 Champion S. at Ascot [on Oct. 17]–and as I haven’t heard what the vet has said, I’m not sure if he’ll make that or not. We just need to know what the problem is. It would be nice if he made Ascot, because that is likely to be soft ground too. It’s rather deflated the week, though.”

Weinfeld added, “I think he’ll probably stay in training next year. “I was hoping we’d have had a good offer from a stud by now–but nothing has come yet, so we could continue next year and hope for a wet year. We’re all very disappointed. But the horse is in one piece, and we live to fight another day.”

Other defectors at this entry stage are: G1 St Leger winner Logician (GB) (Frankel {GB}) for Juddmonte and John Gosden, and Joseph O’Brien’s quintet of Buckhurst (Ire) (Australia {GB}), Crossfirehurricane (Kitten’s Joy), Thames River (GB) (Free Eagle {Ire}), Degraves (Ire) (Camelot {GB}) and New York Girl (Ire) (New Approach {Ire}), leaving a field of 15.

Dual Arc heroine Enable (GB) (Nathaniel {Ire}) is now favoured over brilliant Classic heroine Love (Ire) (Galileo {Ire}), as ground conditions continue to worsen.

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